PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3935092-1 1985 Incubation of 14C-labeled 3,4,3",4"-tetrachlorobiphenyl (TCB) with a reconstituted monooxygenase system containing cytochrome P-450 isolated from 3-methylcholanthrene (MC)-treated rats caused an increase in incorporation of radioactivity to added rat erythrocytes and resulted in covalent binding of reactive metabolites to hemoglobin. Carbon-14 14-17 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 115-131 6380709-8 1984 Gel electrophoresis-fluorography of the proteins in the reconstituted system treated with [4-14C]CP demonstrated localization of the 14C label in the cytochrome P-450 region. Carbon-14 93-96 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 150-166 6415870-1 1983 The specificity of two major types of cytochrome P-450 of rat liver microsomes induced by phenobarbital (PB) and 3-methylcholanthrene (MC) toward activation of three 14C-labeled tetrachlorobiphenyl (TCB) isomers to protein-bound metabolites was examined by intact microsomal and reconstituted monooxygenase systems. Carbon-14 166-169 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 38-54 6601233-4 1983 Alkaline hydrolysis of a cytochrome P-450 fraction obtained by chromatography of solubilized 14C-labeled microsomes on octylamino-Sepharose releases oxalic acid and chloramphenicol oxamic acid, whereas enzymatic digestion releases N-epsilon-chloramphenicol oxamyl lysine in addition. Carbon-14 93-96 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 25-41 7060228-10 1982 Destruction of cytochrome P-450 was accompanied by the appearance of 14C-labelled green pigments separated by HPLC. Carbon-14 69-72 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 15-31 7132955-3 1982 The inactivated cytochrome regains some of its activity upon incubation at 25 degrees or 37 degrees, and experiments with [14C]chloramphenicol show that this partial reactivation is accompanied by the release of some of the 14C originally bound covalently to the cytochrome P-450. Carbon-14 224-227 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 263-279 7132955-4 1982 Previous work has shown that the 14C-labeled material spontaneously released from 14C-labeled cytochrome P-450 is in the form of oxalic acid, and that the latter is derived from a hydroxylamine-labile adduct of chloramphenicol and cytochrome P-450 [Biochem. Carbon-14 33-36 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 94-110 7132955-4 1982 Previous work has shown that the 14C-labeled material spontaneously released from 14C-labeled cytochrome P-450 is in the form of oxalic acid, and that the latter is derived from a hydroxylamine-labile adduct of chloramphenicol and cytochrome P-450 [Biochem. Carbon-14 33-36 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 231-247 7132955-4 1982 Previous work has shown that the 14C-labeled material spontaneously released from 14C-labeled cytochrome P-450 is in the form of oxalic acid, and that the latter is derived from a hydroxylamine-labile adduct of chloramphenicol and cytochrome P-450 [Biochem. Carbon-14 82-85 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 94-110 7132955-4 1982 Previous work has shown that the 14C-labeled material spontaneously released from 14C-labeled cytochrome P-450 is in the form of oxalic acid, and that the latter is derived from a hydroxylamine-labile adduct of chloramphenicol and cytochrome P-450 [Biochem. Carbon-14 82-85 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 231-247 409100-2 1977 The results obtained show that females pre-treated with small amounts of 2,2",4,4"5,5"-hexachlorobiphenyl (o.5 mg/day for 14 consecutive days) have significantly higher elimination rates of 14C (originating from intravenous injection of 4(-14C-progesterone) from the blood plasma, significantly higher content of hepatic cytochrome P-450 and significantly heavier livers than control females. Carbon-14 190-193 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 321-337