PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10983521-6 2000 These species comparisons were evaluated against toxicokinetic studies conducted in animals exposed by nose-only inhalation to 20 ppm 14C-labeled CCl4 for 4 h. The toxicokinetic study results are consistent with the in vivo rates of metabolism, with rats eliminating less radioactivity associated with metabolism (14CO2 and urine/feces) and more radioactivity associated with the parent compound (radioactivity trapped on charcoal) compared to either hamsters or mice. Carbon-14 134-137 C-C motif chemokine ligand 4 Rattus norvegicus 146-150 11531102-3 2001 (1) Covalent binding of 14C-labeled metabolites was detected in hepatocytes immediately after exposure to CCl4. Carbon-14 24-27 C-C motif chemokine ligand 4 Rattus norvegicus 106-110 11531102-5 2001 (3) [14C]-CCl4 was bound to lipids and to proteins throughout subcellular fractions. Carbon-14 5-8 C-C motif chemokine ligand 4 Rattus norvegicus 10-14 1907503-1 1991 The effect of o-benzoquinones on free radical reactions stimulated in rat liver microsomes was studied by using 14C-labeled CCl4. Carbon-14 112-115 C-C motif chemokine ligand 4 Rattus norvegicus 124-128 7551815-5 1995 Deposition of the carbon from [14C] glucose into glycogen was stimulated at high glucose levels and was markedly reduced in the CCl4-injured liver compared to the normal liver (0.58 +/- 0.33 mumol vs 1.44 +/- 0.20 mumol at 20 mM, P < 0.01). Carbon-14 31-34 C-C motif chemokine ligand 4 Rattus norvegicus 128-132 7659836-2 1995 The [14C]aminopyrine breath test (ABT) values in rats with CCl4-induced liver injury were reduced by 34% compared with those in rats with normal liver. Carbon-14 5-8 C-C motif chemokine ligand 4 Rattus norvegicus 59-63 1907503-2 1991 It was found that o-benzoquinones decrease the amount of 14C from CCl4 covalently bound to proteins and lipids. Carbon-14 57-60 C-C motif chemokine ligand 4 Rattus norvegicus 66-70 2469794-7 1987 Chlordecone treatment also increased hepatic cytochrome P-450 levels by 67% and resulted in an increase in the covalent binding of [14-C]-CCl4-derived metabolites to microsomal protein and lipid in vivo. Carbon-14 132-136 C-C motif chemokine ligand 4 Rattus norvegicus 138-142 2833257-0 1988 Free and small peptide-bound [14C]hydroxyproline synthesis in rat liver in vitro in CCl4-induced hepatic fibrosis. Carbon-14 30-33 C-C motif chemokine ligand 4 Rattus norvegicus 84-88 2833257-3 1988 In the CCl4-treated rat liver, where the hepatic hydroxyproline content was increased 4.6-fold, the protein-bound [14C]hydroxyproline synthesis was significantly increased 1.5-fold, but free and small peptide-bound [14C]hydroxyproline synthesis was decreased into 70%. Carbon-14 115-118 C-C motif chemokine ligand 4 Rattus norvegicus 7-11 2833257-3 1988 In the CCl4-treated rat liver, where the hepatic hydroxyproline content was increased 4.6-fold, the protein-bound [14C]hydroxyproline synthesis was significantly increased 1.5-fold, but free and small peptide-bound [14C]hydroxyproline synthesis was decreased into 70%. Carbon-14 216-219 C-C motif chemokine ligand 4 Rattus norvegicus 7-11 1696756-12 1990 These data indicate that the more extensive metabolism of CCl4, as represented by 14CO2 formation and 14C-label bound to hepatic tissue, in gerbils as compared with rats, may partially explain the high sensitivity of gerbils to CCl4 toxicity. Carbon-14 82-85 C-C motif chemokine ligand 4 Rattus norvegicus 58-62 2837346-3 1988 CCl4 metabolism was measured as (i) covalent binding of [14C]-CCl4 to membrane protein, (ii) electron spin resonance spin-trapping of CCl3. Carbon-14 57-60 C-C motif chemokine ligand 4 Rattus norvegicus 0-4 2837346-3 1988 CCl4 metabolism was measured as (i) covalent binding of [14C]-CCl4 to membrane protein, (ii) electron spin resonance spin-trapping of CCl3. Carbon-14 57-60 C-C motif chemokine ligand 4 Rattus norvegicus 62-66 3084329-9 1986 The quantities of 14C noted in the feces and urine suggest that more than 60% of the inhaled CCl4 was metabolized. Carbon-14 18-21 C-C motif chemokine ligand 4 Rattus norvegicus 93-97 3508441-3 1987 Comparing the kinetics of inhibition of lipoprotein secretion with that of CCl4-bioactivation it was found, that covalent binding of (14C)-CCl4 occurred at early time points (5 min) after CCl4 administration and inhibited the lipoprotein secretion. Carbon-14 133-138 C-C motif chemokine ligand 4 Rattus norvegicus 75-79 3508441-3 1987 Comparing the kinetics of inhibition of lipoprotein secretion with that of CCl4-bioactivation it was found, that covalent binding of (14C)-CCl4 occurred at early time points (5 min) after CCl4 administration and inhibited the lipoprotein secretion. Carbon-14 133-138 C-C motif chemokine ligand 4 Rattus norvegicus 139-143 3508441-3 1987 Comparing the kinetics of inhibition of lipoprotein secretion with that of CCl4-bioactivation it was found, that covalent binding of (14C)-CCl4 occurred at early time points (5 min) after CCl4 administration and inhibited the lipoprotein secretion. Carbon-14 133-138 C-C motif chemokine ligand 4 Rattus norvegicus 139-143 3699332-5 1986 The 11.5-hr/day exposure schedule, compared to rats exposed 8-hr/day, produced minor changes in the distribution and concentration of 14C (CCl4 equivalents) in various tissues. Carbon-14 134-137 C-C motif chemokine ligand 4 Rattus norvegicus 139-143 4065314-4 1985 While CCl4 caused polyribosomal disaggregation and decreased [14C]leucine incorporation into liver proteins in vitro and in vivo, treatment with tryptophan, cysteine, or both caused a shift in polyribosomes toward heavier aggregation and protein synthesis was increased. Carbon-14 62-65 C-C motif chemokine ligand 4 Rattus norvegicus 6-10 6437407-8 1984 Stronger associations were found between the magnitude of liver injury at 24 hr (quantitated as serum glutamate-pyruvate transaminase activity) and the extent or rate of CCl4 metabolism by pathways leading to CO2 and CHCl3 than by pathways leading to 14C-metabolites bound in liver or excreted in urine. Carbon-14 251-254 C-C motif chemokine ligand 4 Rattus norvegicus 170-174 145760-1 1977 There was more persistent methylation of liver DNA from rats given [14C]DMN if it was given during liver regeneration, either after partial hepatectomy or a dose of CCl4 compared to otherwise untreated rats. Carbon-14 68-71 C-C motif chemokine ligand 4 Rattus norvegicus 165-169 3952367-1 1986 [14C]-Carbon tetrachloride (CCl4) entered extensively into the liver and, to the small extent, into the brain 3 hr following the intragastric administration of the hepatotoxic dose. Carbon-14 1-4 C-C motif chemokine ligand 4 Rattus norvegicus 28-32 4065314-7 1985 Using isolated hepatocytes, CCl4 caused decreases in cell viability, in release of LDH, and in [14C]leucine incorporation into protein. Carbon-14 96-99 C-C motif chemokine ligand 4 Rattus norvegicus 28-32 6474512-1 1984 Radioactivity from [14C]CCl4 was bound to highly purified mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) prepared from livers of rats after a single dose of [14C]CCl4. Carbon-14 20-23 C-C motif chemokine ligand 4 Rattus norvegicus 24-28 6474512-1 1984 Radioactivity from [14C]CCl4 was bound to highly purified mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) prepared from livers of rats after a single dose of [14C]CCl4. Carbon-14 20-23 C-C motif chemokine ligand 4 Rattus norvegicus 164-168 6430572-5 1984 Activation of carbon tetrachloride, measured as covalent binding of [14C] CCl4, spin-trapping of CCl3 and CCl4-stimulated lipid peroxidation, was much lower in liver microsomes from CPP-treated rats. Carbon-14 69-72 C-C motif chemokine ligand 4 Rattus norvegicus 74-78 7071415-5 1982 14C from CCl4 covalently binds to heme and heme degradation products from liver CL-binding particles from rats treated with 14CCl4. Carbon-14 0-3 C-C motif chemokine ligand 4 Rattus norvegicus 9-13