PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25011481-5	2014	RESULTS: The IRE1 endoribonuclease inhibitors 4mu8c and MKC-3946 prevented the splicing of the XBP1 mRNA in response to ER stress caused by mutant proinsulin production.	MKC3946	56-64	X-box binding protein 1	Homo sapiens	95-99	
26934650-4	2016	IRE1alpha RNase inhibitors [MKC-3946, 2-hydroxy-1-naphthaldehyde (HNA), STF-083010 and toyocamycin] blocked XBP1 mRNA splicing and exhibited cytotoxicity against AML cells.	MKC3946	28-36	X-box binding protein 1	Homo sapiens	108-112	
22538852-3	2012	In this study, we examined whether IRE1alpha-XBP1 pathway is a potential therapeutic target in MM using a small-molecule IRE1alpha endoribonuclease domain inhibitor MKC-3946.	MKC3946	165-173	X-box binding protein 1	Homo sapiens	45-49	
22538852-8	2012	Finally, MKC-3946 inhibited XBP1 splicing in a model of ER stress in vivo, associated with significant growth inhibition of MM cells.	MKC3946	9-17	X-box binding protein 1	Homo sapiens	28-32