PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8492300-1 1993 For organophosphates or phosphonates to initiate delayed neuropathy two steps are necessary: (1) progressive covalent reaction with neuropathy target esterase (NTE) to produce a form of inhibited NTE which can be reactivated by incubation with aqueous potassium fluoride (KF) and (2) progressive "aging" of inhibited NTE to a form which can no longer be reactivated by KF. Organophosphonates 24-36 patatin like phospholipase domain containing 6 Homo sapiens 132-158 8492300-1 1993 For organophosphates or phosphonates to initiate delayed neuropathy two steps are necessary: (1) progressive covalent reaction with neuropathy target esterase (NTE) to produce a form of inhibited NTE which can be reactivated by incubation with aqueous potassium fluoride (KF) and (2) progressive "aging" of inhibited NTE to a form which can no longer be reactivated by KF. Organophosphonates 24-36 patatin like phospholipase domain containing 6 Homo sapiens 160-163 8492300-1 1993 For organophosphates or phosphonates to initiate delayed neuropathy two steps are necessary: (1) progressive covalent reaction with neuropathy target esterase (NTE) to produce a form of inhibited NTE which can be reactivated by incubation with aqueous potassium fluoride (KF) and (2) progressive "aging" of inhibited NTE to a form which can no longer be reactivated by KF. Organophosphonates 24-36 patatin like phospholipase domain containing 6 Homo sapiens 196-199 8492300-1 1993 For organophosphates or phosphonates to initiate delayed neuropathy two steps are necessary: (1) progressive covalent reaction with neuropathy target esterase (NTE) to produce a form of inhibited NTE which can be reactivated by incubation with aqueous potassium fluoride (KF) and (2) progressive "aging" of inhibited NTE to a form which can no longer be reactivated by KF. Organophosphonates 24-36 patatin like phospholipase domain containing 6 Homo sapiens 196-199 1446009-3 1992 Optimized probes for NTE should meet the following specifications: highest potency achievable; rapid aging perhaps associated with alkylation; preferably a phosphonate so there are only two leaving groups. Organophosphonates 156-167 patatin like phospholipase domain containing 6 Homo sapiens 21-24