PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30145050-5 2018 Furthermore, we determined the crystal structures of JAK1, JAK2, JAK3, and TYK2 in a complex with peficitinib, and revealed that the 1H-pyrrolo[2,3-b]pyridine-5-carboxamide scaffold of peficitinib forms triple hydrogen bonds with the hinge region. 1H-pyrrolo[2,3-b]pyridine-5-carboxamide 133-172 Janus kinase 1 Homo sapiens 53-57 30145050-7 2018 WaterMap analysis of the crystal structures suggests that unfavorable water molecules are the likely reason for the difference in orientation of the 1H-pyrrolo[2,3-b]pyridine-5-carboxamide scaffold to the hinge region among JAKs. 1H-pyrrolo[2,3-b]pyridine-5-carboxamide 149-188 Janus kinase 1 Homo sapiens 224-228