PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23273608-2	2013	Heterodimers comprised of dimethoxyindanone (from donepezil), hupyridone (from HupA), and connected with a multimethylene linker, were identified as potent and selective inhibitors of AChE.	5-amino-5,6,7,8-tetrahydroquinolin-2(1H)-one	62-72	acetylcholinesterase (Cartwright blood group)	Homo sapiens	184-188	
16076210-1	2005	Recently, alkylene-linked heterodimers of tacrine (1) and 5-amino-5,6,7,8-tetrahydroquinolinone (2, hupyridone) were shown to exhibit higher acetylcholinesterase (AChE) inhibition than either monomeric 1 or 2.	5-amino-5,6,7,8-tetrahydroquinolin-2(1H)-one	100-110	acetylcholinesterase (Cartwright blood group)	Homo sapiens	141-161	
16076210-1	2005	Recently, alkylene-linked heterodimers of tacrine (1) and 5-amino-5,6,7,8-tetrahydroquinolinone (2, hupyridone) were shown to exhibit higher acetylcholinesterase (AChE) inhibition than either monomeric 1 or 2.	5-amino-5,6,7,8-tetrahydroquinolin-2(1H)-one	100-110	acetylcholinesterase (Cartwright blood group)	Homo sapiens	163-167	
34156230-3	2021	We have previously designed and synthesized dimeric tacrine(10)-hupyridone (A10E), a novel tacrine derivative with acetylcholinesterase (AChE) inhibition and brain-derived neurotrophic factor (BDNF) activation activity, by linking tacrine and a fragment of huperzine A.	5-amino-5,6,7,8-tetrahydroquinolin-2(1H)-one	64-74	acetylcholinesterase (Cartwright blood group)	Homo sapiens	115-135	
34156230-3	2021	We have previously designed and synthesized dimeric tacrine(10)-hupyridone (A10E), a novel tacrine derivative with acetylcholinesterase (AChE) inhibition and brain-derived neurotrophic factor (BDNF) activation activity, by linking tacrine and a fragment of huperzine A.	5-amino-5,6,7,8-tetrahydroquinolin-2(1H)-one	64-74	acetylcholinesterase (Cartwright blood group)	Homo sapiens	137-141