PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11854911-1 2001 AIM: To study the influence of inducers of drug metabolism enzyme, beta-naphthoflavone (BNF) and dexamethasone (DEX), on the stereoselective metabolism of propafenone in the rat hepatic microsomes. Propafenone 155-166 natriuretic peptide B Rattus norvegicus 88-91 11854911-2 2001 METHODS: Phase I metabolism of propafenone was studied using the microsomes induced by BNF and DEX and the non-induced microsome was used as the control. Propafenone 31-42 natriuretic peptide B Rattus norvegicus 87-90 11854911-5 2001 RESULTS: The metabolite of propafenone, N-desalkylpropafenone, was found after incubation of propafenone with the rat hepatic microsomes induced by BNF and DEX. Propafenone 27-38 natriuretic peptide B Rattus norvegicus 148-151 11854911-5 2001 RESULTS: The metabolite of propafenone, N-desalkylpropafenone, was found after incubation of propafenone with the rat hepatic microsomes induced by BNF and DEX. Propafenone 50-61 natriuretic peptide B Rattus norvegicus 148-151 11854911-18 2001 CONCLUSION: CYP1A subfamily(induced by BNF) and CYP3A4 (induced by DEX) have pronounced contribution to propafenone N-desalkylation which exhibited stereoselectivity depending on substrate concentration. Propafenone 104-115 natriuretic peptide B Rattus norvegicus 39-42