PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31365252-3 2019 Herein, we report the discovery of BI-4916, a prodrug of the co-factor nicotinamide adenine dinucleotide (NADH/NAD+)-competitive PHGDH inhibitor BI-4924, which has shown high selectivity against the majority of other dehydrogenase targets. BI-4916 35-42 phosphoglycerate dehydrogenase Homo sapiens 129-134 35577770-7 2022 We observe that increased serine de novo synthesis (SSP) supports mitochondrial serine catabolism and inhibition of SSP using the competitive PHGDH-inhibitor BI-4916 reduces cancer cell migration. BI-4916 158-165 phosphoglycerate dehydrogenase Homo sapiens 142-147