PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27459794-3 2016 Western blot was used to evaluate the expression of Nrf2, quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (10-1) during sodium arsenite-induced transformation of HBE cells. sodium arsenite 125-140 heme oxygenase 1 Homo sapiens 94-110 28347842-3 2017 We examined the involvement of heme metabolism in the induction of HO-1 by the inducers sulforaphane and sodium arsenite. sodium arsenite 105-120 heme oxygenase 1 Homo sapiens 67-71 28347842-4 2017 METHODS: We examined the expression of HO-1 in sulforaphane-, sodium arsenite- and CORM3-treated HEK293T cells, by measuring the transcriptional activity and levels of mRNA and protein. sodium arsenite 62-77 heme oxygenase 1 Homo sapiens 39-43 28229933-5 2017 We investigated the activation of nuclear factor-E2-related factor 2 (Nrf2) which regulates various antioxidant genes including heme oxygenase-1 (HMOX1), following exposure to sodium arsenite or cadmium chloride in lamin knockdown human cell lines and primary HGPS human fibroblasts. sodium arsenite 176-191 heme oxygenase 1 Homo sapiens 128-144 28229933-5 2017 We investigated the activation of nuclear factor-E2-related factor 2 (Nrf2) which regulates various antioxidant genes including heme oxygenase-1 (HMOX1), following exposure to sodium arsenite or cadmium chloride in lamin knockdown human cell lines and primary HGPS human fibroblasts. sodium arsenite 176-191 heme oxygenase 1 Homo sapiens 146-151 27459794-7 2016 CONCLUSION: The transformation of HBE cells induced by chronic exposure to sodium arsenite is mediated by decreased Nrf2 level and its downstream NQO1 and HO-1 protein, which subsequently promote the malignant proliferation. sodium arsenite 75-90 heme oxygenase 1 Homo sapiens 155-159 22580386-4 2012 Moreover, induction of HO-1 with sodium arsenite led to 2.4-fold (p = 0.01) accumulation of intracellular UCB over basal level while sodium azide-derived oxidative stress resulted in a 60% drop (p < 0.001). sodium arsenite 33-48 heme oxygenase 1 Homo sapiens 23-27 23824679-1 2013 In the present study, the role of heme oxygenase (HO)-1 in sodium arsenite (arsenite)-induced neurotoxicity was investigated using primary cultured cortical neurons. sodium arsenite 59-74 heme oxygenase 1 Homo sapiens 34-55 21809430-0 2013 Sodium arsenite induced reactive oxygen species generation, nuclear factor (erythroid-2 related) factor 2 activation, heme oxygenase-1 expression, and glutathione elevation in Chang human hepatocytes. sodium arsenite 0-15 heme oxygenase 1 Homo sapiens 118-134 21861350-5 2011 Moreover, HO-1 mRNA expression were also significantly induced by sodium arsenite exposure, and a definite dose-effect relationship was confirmed (P < 0.01). sodium arsenite 66-81 heme oxygenase 1 Homo sapiens 10-14 21910007-1 2011 Treatment of melanoma cells by sodium arsenite or statins (simvastatin and lovastatin) dramatically modified activities of the main cell signaling pathways resulting in the induction of heme oxygenase-1 (HO-1) and in a downregulation of cyclooxygenase-2 (COX-2) protein levels. sodium arsenite 31-46 heme oxygenase 1 Homo sapiens 186-202 21910007-1 2011 Treatment of melanoma cells by sodium arsenite or statins (simvastatin and lovastatin) dramatically modified activities of the main cell signaling pathways resulting in the induction of heme oxygenase-1 (HO-1) and in a downregulation of cyclooxygenase-2 (COX-2) protein levels. sodium arsenite 31-46 heme oxygenase 1 Homo sapiens 204-208 21910007-4 2011 We demonstrated in the present study that treatment by sodium arsenite or statins with an additional inhibition of HO-1 expression (or activation) caused a substantial upregulation of apoptosis in melanoma cells. sodium arsenite 55-70 heme oxygenase 1 Homo sapiens 115-119 20083128-4 2010 The present study investigates the role of heme oxygenase-1 (HO-1) in sodium arsenite-mediated angiogenesis in vitro. sodium arsenite 70-85 heme oxygenase 1 Homo sapiens 43-59 20083128-4 2010 The present study investigates the role of heme oxygenase-1 (HO-1) in sodium arsenite-mediated angiogenesis in vitro. sodium arsenite 70-85 heme oxygenase 1 Homo sapiens 61-65 18996220-0 2009 Sodium arsenite induces ROS generation, DNA oxidative damage, HO-1 and c-Myc proteins, NF-kappaB activation and cell proliferation in human breast cancer MCF-7 cells. sodium arsenite 0-15 heme oxygenase 1 Homo sapiens 62-66 10906077-6 2000 Treatments of isolated tubules with either sodium arsenite, known to induce HO-1, or hematin, an HO substrate, resulted in 4.4- and 1.8-fold, respectively, increases in cGMP levels. sodium arsenite 43-58 heme oxygenase 1 Homo sapiens 76-80 16530877-8 2006 Sodium arsenite, a strong inducer of oxidative stress and HO-1, reduced Bach1 expression in wild type Huh-7 cells, and NAC partially abrogated this decrease. sodium arsenite 0-15 heme oxygenase 1 Homo sapiens 58-62 15689417-0 2005 Oxidative stress mediates sodium arsenite-induced expression of heme oxygenase-1, monocyte chemoattractant protein-1, and interleukin-6 in vascular smooth muscle cells. sodium arsenite 26-41 heme oxygenase 1 Homo sapiens 64-80 15741166-4 2005 Presently, small interference (si) RNA constructs were used to investigate the role of human BVR in sodium arsenite (As)-mediated induction of HO-1 and in cytoprotection against apoptosis. sodium arsenite 100-115 heme oxygenase 1 Homo sapiens 143-147 11078701-8 2000 On the other hand, sodium arsenite, a known activator of the stress response pathway, induced HO-1 mRNA expression but lacked a promoting effect on TG production. sodium arsenite 19-34 heme oxygenase 1 Homo sapiens 94-98 9747510-7 1998 In addition to hyperoxia, sodium arsenite (NaAsO2), cadmium chloride (CdCl(2)) and hydrogen peroxide (H2O2), which are reactive oxygen intermediates (ROI) generators, increased the HO-1 mRNA level by 11-, 22- and 2.5-fold, respectively. sodium arsenite 26-41 heme oxygenase 1 Homo sapiens 181-185 9747510-7 1998 In addition to hyperoxia, sodium arsenite (NaAsO2), cadmium chloride (CdCl(2)) and hydrogen peroxide (H2O2), which are reactive oxygen intermediates (ROI) generators, increased the HO-1 mRNA level by 11-, 22- and 2.5-fold, respectively. sodium arsenite 43-49 heme oxygenase 1 Homo sapiens 181-185 9722676-0 1998 Involvement of the tyrosine phosphorylation pathway in induction of human heme oxygenase-1 by hemin, sodium arsenite, and cadmium chloride. sodium arsenite 101-116 heme oxygenase 1 Homo sapiens 74-90 9722676-1 1998 The effect of a tyrosine kinase inhibitor, herbimycin A, on the induction of heme oxygenase-1 (HO-1) mRNA in HeLa cells upon exposure to hemin, sodium arsenite and cadmium chloride was examined. sodium arsenite 144-159 heme oxygenase 1 Homo sapiens 77-93 9722676-1 1998 The effect of a tyrosine kinase inhibitor, herbimycin A, on the induction of heme oxygenase-1 (HO-1) mRNA in HeLa cells upon exposure to hemin, sodium arsenite and cadmium chloride was examined. sodium arsenite 144-159 heme oxygenase 1 Homo sapiens 95-99