PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3753897-2 1986 Posttreatment of sodium arsenite drastically increases the cytotoxicity, clastogenicity, hypoxanthine-guanine phosphoribosyltransferase mutagenicity, and inhibition of mitosis and cell proliferation induced by MMS. sodium arsenite 17-32 hypoxanthine-guanine phosphoribosyltransferase Cricetulus griseus 89-135 1396606-2 1992 However, posttreatment of ultraviolet light (UV) irradiated cells with sodium arsenite synergistically enhances the mutation frequency on the hypoxanthine (guanine) phosphoribosyltransferase locus. sodium arsenite 71-86 hypoxanthine-guanine phosphoribosyltransferase Cricetulus griseus 142-190 1396606-3 1992 To investigate the molecular mechanism of the comutagenic effects of sodium arsenite, we characterized the alterations of nucleotide sequences in 30 UV-induced and 39 sodium arsenite enhanced hprt mutants from Chinese hamster ovary K1 cells by direct sequencing of mRNA-PCR amplified cDNA. sodium arsenite 69-84 hypoxanthine-guanine phosphoribosyltransferase Cricetulus griseus 192-196 1396606-3 1992 To investigate the molecular mechanism of the comutagenic effects of sodium arsenite, we characterized the alterations of nucleotide sequences in 30 UV-induced and 39 sodium arsenite enhanced hprt mutants from Chinese hamster ovary K1 cells by direct sequencing of mRNA-PCR amplified cDNA. sodium arsenite 167-182 hypoxanthine-guanine phosphoribosyltransferase Cricetulus griseus 192-196 2484616-4 1989 We now confirm the nonmutagenicity of sodium arsenite in line G12, a pSV2gpt-transformed V79 (hprt-) cell line, which is able to detect multilocus deletions in addition to point mutations and small deletions. sodium arsenite 38-53 hypoxanthine-guanine phosphoribosyltransferase Cricetulus griseus 94-98 3753897-1 1986 Pretreatment of sodium arsenite reduces hypoxanthine-guanine phosphoribosyltransferase mutagenicity and overcomes the inhibition of mitosis and cell proliferation but has no apparent effect on the cytotoxicity and clastogenicity in methyl methanesulfonate (MMS)-treated Chinese hamster ovary cells. sodium arsenite 16-31 hypoxanthine-guanine phosphoribosyltransferase Cricetulus griseus 40-86 3753679-4 1986 Furthermore, the mutagenicity of cis-Pt(II) at the hypoxanthine-guanine phosphoribosyl transferase locus is also potentiated by sodium arsenite in CHO cells. sodium arsenite 128-143 hypoxanthine-guanine phosphoribosyltransferase Cricetulus griseus 51-98