PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
3606855-1	1987	Heat shock protein (HSP) synthesis was studied in the Xenopus epithelial cell line A6 in response to heat and sodium arsenite, either singly or together.	sodium arsenite	110-125	heat shock 70kDa protein L homeolog	Xenopus laevis	0-18	
3196465-1	1988	Continuous exposure of a Xenopus laevis kidney epithelial cell line, A6, to either heat shock (33 degrees C) or sodium arsenite (50 microM) resulted in transient but markedly different temporal patterns of heat-shock protein (HSP) synthesis and HSP 70 and 30 mRNA accumulation.	sodium arsenite	112-127	heat shock 70kDa protein L homeolog	Xenopus laevis	206-224	
3196465-1	1988	Continuous exposure of a Xenopus laevis kidney epithelial cell line, A6, to either heat shock (33 degrees C) or sodium arsenite (50 microM) resulted in transient but markedly different temporal patterns of heat-shock protein (HSP) synthesis and HSP 70 and 30 mRNA accumulation.	sodium arsenite	112-127	heat shock 70kDa protein L homeolog	Xenopus laevis	226-229	
3196465-1	1988	Continuous exposure of a Xenopus laevis kidney epithelial cell line, A6, to either heat shock (33 degrees C) or sodium arsenite (50 microM) resulted in transient but markedly different temporal patterns of heat-shock protein (HSP) synthesis and HSP 70 and 30 mRNA accumulation.	sodium arsenite	112-127	heat shock 70kDa protein L homeolog	Xenopus laevis	245-248	
3196465-2	1988	Heat-shock-induced synthesis of HSPs was detectable within 1 h and reached maximum levels by 2-3 h. While sodium arsenite induced the synthesis of some HSPs within 1 h, maximal HSP synthesis did not occur until 12 h. The pattern of HSP 70 and 30 mRNA accumulation was similar to the response observed at the protein level.	sodium arsenite	106-121	heat shock 70kDa protein L homeolog	Xenopus laevis	32-35	
3196465-2	1988	Heat-shock-induced synthesis of HSPs was detectable within 1 h and reached maximum levels by 2-3 h. While sodium arsenite induced the synthesis of some HSPs within 1 h, maximal HSP synthesis did not occur until 12 h. The pattern of HSP 70 and 30 mRNA accumulation was similar to the response observed at the protein level.	sodium arsenite	106-121	heat shock 70kDa protein L homeolog	Xenopus laevis	152-155	
3196465-7	1988	In conclusion, heat shock and sodium arsenite induce a similar set of HSPs but maximum synthesis of the HSP is temporally separated by 12-24 h.	sodium arsenite	30-45	heat shock 70kDa protein L homeolog	Xenopus laevis	70-73	
3606855-1	1987	Heat shock protein (HSP) synthesis was studied in the Xenopus epithelial cell line A6 in response to heat and sodium arsenite, either singly or together.	sodium arsenite	110-125	heat shock 70kDa protein L homeolog	Xenopus laevis	20-23	
3606855-3	1987	In cultures exposed to 10 microM sodium arsenite at 30 degrees C, HSP synthesis in the 68- to 73-kDa and 29- to 31-kDa regions was much greater than the HSP synthesis in response to each treatment individually.	sodium arsenite	33-48	heat shock 70kDa protein L homeolog	Xenopus laevis	66-69	
3606855-3	1987	In cultures exposed to 10 microM sodium arsenite at 30 degrees C, HSP synthesis in the 68- to 73-kDa and 29- to 31-kDa regions was much greater than the HSP synthesis in response to each treatment individually.	sodium arsenite	33-48	heat shock 70kDa protein L homeolog	Xenopus laevis	153-156	
3606855-6	1987	Sodium arsenite (10-100 microM) also induced the accumulation of both HSP 70 and 30 mRNAs.	sodium arsenite	0-15	heat shock 70kDa protein L homeolog	Xenopus laevis	70-76	
3606855-7	1987	Finally, a mild heat shock (30 degrees C) plus a low concentration of sodium arsenite (10 microM) acted synergistically on HSP 70 and 30 mRNA accumulation in A6 cells.	sodium arsenite	70-85	heat shock 70kDa protein L homeolog	Xenopus laevis	123-126	
3606855-8	1987	Thus sodium arsenite and heat act synergistically at the level of both HSP synthesis and HSP mRNA accumulation.	sodium arsenite	5-20	heat shock 70kDa protein L homeolog	Xenopus laevis	71-74	
3606855-8	1987	Thus sodium arsenite and heat act synergistically at the level of both HSP synthesis and HSP mRNA accumulation.	sodium arsenite	5-20	heat shock 70kDa protein L homeolog	Xenopus laevis	89-92	
23919948-0	2013	Enhanced HSP30 and HSP70 accumulation in Xenopus cells subjected to concurrent sodium arsenite and cadmium chloride stress.	sodium arsenite	79-94	heat shock 70kDa protein L homeolog	Xenopus laevis	19-24	
3828114-3	1987	Exposure of Xenopus laevis embryos to other stressors, such as sodium arsenite or ethanol, also induced a developmental stage-dependent accumulation of hsp 70 mRNA.	sodium arsenite	63-78	heat shock 70kDa protein L homeolog	Xenopus laevis	152-158	
26260897-1	2015	In the present study, treatment of Xenopus laevis A6 kidney epithelial cells with the proteasomal inhibitor, MG132, or the environmental toxicants, sodium arsenite or cadmium chloride, induced the accumulation of the small heat shock protein, HSP30, in total and in both soluble and insoluble protein fractions.	sodium arsenite	148-163	heat shock 70kDa protein L homeolog	Xenopus laevis	223-241	
23919948-8	2013	The addition of a mild heat shock further enhanced the accumulation of HSP30 and HSP70 in response to relatively low concentrations of sodium arsenite plus cadmium chloride.	sodium arsenite	135-150	heat shock 70kDa protein L homeolog	Xenopus laevis	81-86	
19358893-0	2009	Simultaneous exposure of Xenopus A6 kidney epithelial cells to concurrent mild sodium arsenite and heat stress results in enhanced hsp30 and hsp70 gene expression and the acquisition of thermotolerance.	sodium arsenite	79-94	heat shock 70kDa protein L homeolog	Xenopus laevis	141-146	
19358893-1	2009	In this study, we examined the effect of concurrent low concentrations of sodium arsenite and mild heat shock temperatures on hsp30 and hsp70 gene expression in Xenopus A6 kidney epithelial cells.	sodium arsenite	74-89	heat shock 70kDa protein L homeolog	Xenopus laevis	136-141	
19358893-2	2009	RNA blot hybridization and immunoblot analysis revealed that exposure of A6 cells to 1-10 microM sodium arsenite at a mild heat shock temperature of 30 degrees C enhanced hsp30 and hsp70 gene expression to a much greater extent than found with either stress individually.	sodium arsenite	97-112	heat shock 70kDa protein L homeolog	Xenopus laevis	181-186	
19358893-3	2009	In cells treated simultaneously with 10 microM sodium arsenite and different heat shock temperatures, enhanced accumulation of HSP30 and HSP70 protein was first detected at 26 degrees C with larger responses at 28 and 30 degrees C. HSF1 activity was involved in combined stress-induced hsp gene expression since the HSF1 activation inhibitor, KNK437, inhibited HSP30 and HSP70 accumulation.	sodium arsenite	47-62	heat shock 70kDa protein L homeolog	Xenopus laevis	137-150	
19358893-3	2009	In cells treated simultaneously with 10 microM sodium arsenite and different heat shock temperatures, enhanced accumulation of HSP30 and HSP70 protein was first detected at 26 degrees C with larger responses at 28 and 30 degrees C. HSF1 activity was involved in combined stress-induced hsp gene expression since the HSF1 activation inhibitor, KNK437, inhibited HSP30 and HSP70 accumulation.	sodium arsenite	47-62	heat shock 70kDa protein L homeolog	Xenopus laevis	137-142