PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22102309-4	2011	We have previously employed an in vitro model system of human epidermal keratinocytes to study the effects of submicromolar concentrations of sodium arsenite on cyclin D1 expression.	sodium arsenite	142-157	cyclin D1	Homo sapiens	161-170	
17005224-2	2006	To gain insight into the oncogenic properties of arsenic, we studied the expression of cyclin D1 in cultured human epidermal keratinocytes treated with submicromolar concentrations of sodium arsenite.	sodium arsenite	184-199	cyclin D1	Homo sapiens	87-96	
16283521-15	2005	Furthermore, exposure of cells to NaAsO2 resulted in a significant inhibition of expression of the cell cycle and growth regulating gene, cyclin D1.	sodium arsenite	34-40	cyclin D1	Homo sapiens	138-147	
16283521-17	2005	Transfection of cells with SiRNA specifically targeting eIF4E gene expression resulted in a significant inhibition of cyclin D1 gene suggesting that the observed inhibition of cyclin D1 gene in the NaAsO2-treated cells is most likely mediated through inhibition of eIF4E gene.	sodium arsenite	198-204	cyclin D1	Homo sapiens	118-127	
16283521-17	2005	Transfection of cells with SiRNA specifically targeting eIF4E gene expression resulted in a significant inhibition of cyclin D1 gene suggesting that the observed inhibition of cyclin D1 gene in the NaAsO2-treated cells is most likely mediated through inhibition of eIF4E gene.	sodium arsenite	198-204	cyclin D1	Homo sapiens	176-185	
16283521-18	2005	Taken together, our results indicate that the exposure of cells to NaAsO2 resulted in cytotoxicity and cell death, at least in part, due to the inhibition of eIF4E gene expression leading to diminished cellular levels of critical genes such as cyclin D1.	sodium arsenite	67-73	cyclin D1	Homo sapiens	244-253