PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33039867-0 2021 ROS-mediated genotoxic stress is involved in NaAsO2-induced cell cycle arrest, stemness enhancement and chemoresistance of prostate cancer cells in a p53-independent manner. sodium arsenite 45-51 tumor protein p53 Homo sapiens 150-153 33039867-10 2021 Phosphor-p53, a downstream molecule of ATM signaling, and p21, a direct target of p53, were upregulated in NaAsO2-exposed DU145 cells. sodium arsenite 107-113 tumor protein p53 Homo sapiens 9-12 33039867-10 2021 Phosphor-p53, a downstream molecule of ATM signaling, and p21, a direct target of p53, were upregulated in NaAsO2-exposed DU145 cells. sodium arsenite 107-113 tumor protein p53 Homo sapiens 82-85 33039867-11 2021 Unexpectedly, p21 was also elevated in NaAsO2-exposed p53-null PC-3 cells. sodium arsenite 39-45 tumor protein p53 Homo sapiens 54-57 33039867-13 2021 These results suggest that ROS-mediated genotoxic stress is involved in NaAsO2-induced cell cycle arrest, stemness enhancement and chemoresistance of prostate cancer cells in a p53-independent manner. sodium arsenite 72-78 tumor protein p53 Homo sapiens 177-180 22331493-0 2012 Sodium arsenite +- hyperthermia sensitizes p53-expressing human ovarian cancer cells to cisplatin by modulating platinum-DNA damage responses. sodium arsenite 0-15 tumor protein p53 Homo sapiens 43-46 31587475-7 2020 In addition, SA provoked the apoptosis by expanding the p53 and Bax levels, terminal deoxynucleotidyl transferase dUTP nick end labeling, and expression of caspase-3. sodium arsenite 13-15 tumor protein p53 Homo sapiens 56-59 32001831-8 2020 Furthermore, prolonged nicotine exposure interferes with p53 function triggered by sodium arsenite. sodium arsenite 83-98 tumor protein p53 Homo sapiens 57-60 24519527-3 2014 We recently demonstrated that a combination of sodium arsenite (NaAsO2) and hyperthermia sensitizes p53-expressing ovarian cancer cells to cisplatin by modulating DNA repair pathway and enhancing platinum accumulation. sodium arsenite 47-62 tumor protein p53 Homo sapiens 100-103 24519527-3 2014 We recently demonstrated that a combination of sodium arsenite (NaAsO2) and hyperthermia sensitizes p53-expressing ovarian cancer cells to cisplatin by modulating DNA repair pathway and enhancing platinum accumulation. sodium arsenite 64-70 tumor protein p53 Homo sapiens 100-103 22331493-10 2012 XPC siRNA transfection sensitized wild-type p53-expressing cells to cisplatin, suggesting that sodium arsenite +- hyperthermia attenuation of XPC is a mechanism by which wild-type p53-expressing cells are sensitized to cisplatin. sodium arsenite 95-110 tumor protein p53 Homo sapiens 180-183 22331493-11 2012 Hyperthermia +- sodium arsenite enhanced cellular and DNA accumulation of platinum in wild-type p53-expressing cells. sodium arsenite 16-31 tumor protein p53 Homo sapiens 96-99 22331493-13 2012 In conclusion, sodium arsenite +- hyperthermia sensitizes wild-type p53-expressing EOC cells to cisplatin by suppressing DNA repair protein XPC and increasing cellular and DNA platinum accumulation. sodium arsenite 15-30 tumor protein p53 Homo sapiens 68-71 22331493-4 2012 In this study, we examined the role of p53 status in EOC response to a novel combination of cisplatin, sodium arsenite, and hyperthermia. sodium arsenite 103-118 tumor protein p53 Homo sapiens 39-42 22331493-5 2012 Human EOC cells were treated with cisplatin +- 20muM sodium arsenite at 37 C or 39 C for 1 h. Sodium arsenite +- hyperthermia sensitized wild-type p53-expressing (A2780, A2780/CP70, OVCA 420, OVCA 429, and OVCA 433) EOC cells to cisplatin. sodium arsenite 94-109 tumor protein p53 Homo sapiens 147-150 22331493-7 2012 P53 small interfering RNA (siRNA) transfection abrogated sodium arsenite sensitization effect. sodium arsenite 57-72 tumor protein p53 Homo sapiens 0-3 22331493-9 2012 Cotreatment with sodium arsenite +- hyperthermia attenuated cisplatin-induced XPC in wild-type p53-expressing cells. sodium arsenite 17-32 tumor protein p53 Homo sapiens 95-98 22331493-10 2012 XPC siRNA transfection sensitized wild-type p53-expressing cells to cisplatin, suggesting that sodium arsenite +- hyperthermia attenuation of XPC is a mechanism by which wild-type p53-expressing cells are sensitized to cisplatin. sodium arsenite 95-110 tumor protein p53 Homo sapiens 44-47 21292642-4 2011 We found that prolonged exposure of immortalized p53-knocked down human bronchial epithelial cells (p53(low)HBECs) to low levels of arsenite (NaAsO2, 2.5 muM) caused malignant transformation that was accompanied by epithelial to mesenchymal transition (EMT) and reduction in the levels of miR-200 family members. sodium arsenite 142-148 tumor protein p53 Homo sapiens 49-52 21954225-5 2012 METHODS: As-transformed p53lowHBECs were generated by exposing p53-knockdown HBECs to sodium arsenite (2.5 muM) for 16 weeks. sodium arsenite 86-101 tumor protein p53 Homo sapiens 24-27 20390378-5 2011 The NaAsO2 treatment resulted in a marked increase in p53 protein as early as 4 h and in Bcl-2 protein level by 12 h. In addition, p53 downregulation accompanied the combined treatment of NaAsO2 and Na2SeO3. sodium arsenite 4-10 tumor protein p53 Homo sapiens 54-57 20390378-5 2011 The NaAsO2 treatment resulted in a marked increase in p53 protein as early as 4 h and in Bcl-2 protein level by 12 h. In addition, p53 downregulation accompanied the combined treatment of NaAsO2 and Na2SeO3. sodium arsenite 4-10 tumor protein p53 Homo sapiens 131-134 20390378-5 2011 The NaAsO2 treatment resulted in a marked increase in p53 protein as early as 4 h and in Bcl-2 protein level by 12 h. In addition, p53 downregulation accompanied the combined treatment of NaAsO2 and Na2SeO3. sodium arsenite 188-194 tumor protein p53 Homo sapiens 54-57 20390378-5 2011 The NaAsO2 treatment resulted in a marked increase in p53 protein as early as 4 h and in Bcl-2 protein level by 12 h. In addition, p53 downregulation accompanied the combined treatment of NaAsO2 and Na2SeO3. sodium arsenite 188-194 tumor protein p53 Homo sapiens 131-134 20390378-6 2011 Thus, our results indicate upregulation of p53 and Bcl-2 play acrucial role in the NaAsO2-induced G1 arrest and apoptosis of A375 cells and that downregulation p53 appears to contribute to the inhibition by Na2SeO3 of the effects induced by NaAsO2. sodium arsenite 83-89 tumor protein p53 Homo sapiens 43-46 20390378-6 2011 Thus, our results indicate upregulation of p53 and Bcl-2 play acrucial role in the NaAsO2-induced G1 arrest and apoptosis of A375 cells and that downregulation p53 appears to contribute to the inhibition by Na2SeO3 of the effects induced by NaAsO2. sodium arsenite 83-89 tumor protein p53 Homo sapiens 160-163 20390378-6 2011 Thus, our results indicate upregulation of p53 and Bcl-2 play acrucial role in the NaAsO2-induced G1 arrest and apoptosis of A375 cells and that downregulation p53 appears to contribute to the inhibition by Na2SeO3 of the effects induced by NaAsO2. sodium arsenite 241-247 tumor protein p53 Homo sapiens 43-46 17945324-5 2007 These cells were treated with different doses of sodium arsenite (0, 0.1, 1, 5 and 10 microM) for 48 h. A greater reduction in cell viability was observed in the BEAS-2B cells vs. p53 compromised cells (H1355 or p53-inhibited BEAS-2B). sodium arsenite 49-64 tumor protein p53 Homo sapiens 180-183 19010883-2 2008 We report here that treatment of cells with sodium arsenite at the concentrations close to environmental exposure is associated with the up-regulation of Hdm2 and the accumulation of p53 in the cytoplasm. sodium arsenite 44-59 tumor protein p53 Homo sapiens 183-186 17945324-5 2007 These cells were treated with different doses of sodium arsenite (0, 0.1, 1, 5 and 10 microM) for 48 h. A greater reduction in cell viability was observed in the BEAS-2B cells vs. p53 compromised cells (H1355 or p53-inhibited BEAS-2B). sodium arsenite 49-64 tumor protein p53 Homo sapiens 212-215 17906315-10 2007 In conclusion, this study demonstrated that sodium arsenite is genotoxic to uroepithelial cells in vitro, and that it will induce expression of mutant p53 and COX-2 proteins, indicating a possible key event in carcinogenesis. sodium arsenite 44-59 tumor protein p53 Homo sapiens 151-154 12641444-7 2003 Of this group, arsenic trioxide was the strongest inducer of cellular p53, while dimethylarsinic acid, iododimethylarsine, and sodium arsenite also caused p53 induction in a dose- and time-dependent manner. sodium arsenite 127-142 tumor protein p53 Homo sapiens 155-158 12054599-0 2002 Restoration of p53 tumor suppressor pathway in human cervical carcinoma cells by sodium arsenite. sodium arsenite 81-96 tumor protein p53 Homo sapiens 15-18 12054599-5 2002 Two p53-responsive genes, p21(waf1/cip1) and mdm2, were induced after SA treatment. sodium arsenite 70-72 tumor protein p53 Homo sapiens 4-7 12054599-7 2002 SA-induced apoptosis was greatly reduced by expression of a dominant-negative mutated p53. sodium arsenite 0-2 tumor protein p53 Homo sapiens 86-89 12054599-8 2002 In this study, we have first demonstrated that SA did repress E6 and E7 oncogenes, restore the p53 tumor suppressor pathway and induce apoptosis in SiHa cells. sodium arsenite 47-49 tumor protein p53 Homo sapiens 95-98 9434882-0 1997 Induction of p53 protein expression by sodium arsenite. sodium arsenite 39-54 tumor protein p53 Homo sapiens 13-16 9434882-3 1997 Intrigued by these effects and based on the role of p53 on cell proliferation, we tested different concentrations of sodium arsenite for their ability to induce the expression of tumor suppressor gene p53 in different cell lines (HeLa, C-33A. sodium arsenite 117-132 tumor protein p53 Homo sapiens 52-55 9434882-3 1997 Intrigued by these effects and based on the role of p53 on cell proliferation, we tested different concentrations of sodium arsenite for their ability to induce the expression of tumor suppressor gene p53 in different cell lines (HeLa, C-33A. sodium arsenite 117-132 tumor protein p53 Homo sapiens 201-204 9434882-6 1997 Immunoblots showed an increased expression of p53 gene with 1 microM sodium arsenite in Jurkat cells and 10 microM sodium arsenite in HeLa and LCL-EBV cells. sodium arsenite 69-84 tumor protein p53 Homo sapiens 46-49 9434882-6 1997 Immunoblots showed an increased expression of p53 gene with 1 microM sodium arsenite in Jurkat cells and 10 microM sodium arsenite in HeLa and LCL-EBV cells. sodium arsenite 115-130 tumor protein p53 Homo sapiens 46-49 9219564-3 1997 We found that exposure of human lung adenocarcinoma A549 cells to sodium arsenite (0.08-2 microM) or sodium arsenate (30-300 microM), but not dimethylarsenic acid (2-2000 microM), produced significant dose-responsive hypermethylation within a 341-base pair fragment of the promoter of p53. sodium arsenite 66-81 tumor protein p53 Homo sapiens 285-288 34798143-8 2022 Furthermore, NaAsO2 induced phosphorylation of p53 at Ser315, 376, 392, and Thr55, and acetylation of p53 at K370, 382 with a dose-response relationship, suggesting the contribution of PUMA up-regulation to p53 phosphorylation and acetylation. sodium arsenite 13-19 tumor protein p53 Homo sapiens 47-50 34798143-8 2022 Furthermore, NaAsO2 induced phosphorylation of p53 at Ser315, 376, 392, and Thr55, and acetylation of p53 at K370, 382 with a dose-response relationship, suggesting the contribution of PUMA up-regulation to p53 phosphorylation and acetylation. sodium arsenite 13-19 tumor protein p53 Homo sapiens 102-105 34798143-8 2022 Furthermore, NaAsO2 induced phosphorylation of p53 at Ser315, 376, 392, and Thr55, and acetylation of p53 at K370, 382 with a dose-response relationship, suggesting the contribution of PUMA up-regulation to p53 phosphorylation and acetylation. sodium arsenite 13-19 tumor protein p53 Homo sapiens 207-210 34798143-11 2022 To our knowledge, we first reported that NaAsO2 activated phosphorylation of p53 at Ser315, 376, and Thr55, as well as acetylation of p53 at K370. sodium arsenite 41-47 tumor protein p53 Homo sapiens 77-80 34798143-11 2022 To our knowledge, we first reported that NaAsO2 activated phosphorylation of p53 at Ser315, 376, and Thr55, as well as acetylation of p53 at K370. sodium arsenite 41-47 tumor protein p53 Homo sapiens 134-137 13129816-5 2003 As(2)O(3)-induced apoptosis was associated with upregulation of p53 and caspase 3, whereas NaAsO(2)-induced apoptosis was associated with p53 upregulation. sodium arsenite 91-99 tumor protein p53 Homo sapiens 138-141