PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23143138-0 2013 Sodium arsenite exposure inhibits AKT and Stat3 activation, suppresses self-renewal and induces apoptotic death of embryonic stem cells. sodium arsenite 0-15 thymoma viral proto-oncogene 1 Mus musculus 34-37 23143138-4 2013 We demonstrated that the crucial signaling pathway, which was substantially suppressed by sodium arsenite exposure (4 muM) in ESC, was the PI3K-AKT pathway linked with numerous downstream targets that control cell survival and apoptosis. sodium arsenite 90-105 thymoma viral proto-oncogene 1 Mus musculus 144-147 23143138-8 2013 In summary, our data demonstrated suppression of self-renewal and induction of apoptosis in mouse ESC by sodium arsenite exposure, which was further accelerated due to simultaneous inhibition of the protective PI3K-AKT and Stat3-dependent pathways. sodium arsenite 105-120 thymoma viral proto-oncogene 1 Mus musculus 215-218