PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14962831-3 2004 We demonstrated that inhibition of p38 MAPK with SB-203580 and SB-239063 enhanced H(2)O(2)-stimulated ERK phosphorylation, whereas preactivation of p38 MAPK with sodium arsenite reduced H(2)O(2)-stimulated ERK phosphorylation. sodium arsenite 162-177 mitogen-activated protein kinase 1 Homo sapiens 35-38 23219847-11 2013 Sodium arsenite also negatively affects neuronal differentiation of NSC through overactivation of MEK-ERK and suppression of PI3K-AKT. sodium arsenite 0-15 mitogen-activated protein kinase 1 Homo sapiens 102-105 14962831-3 2004 We demonstrated that inhibition of p38 MAPK with SB-203580 and SB-239063 enhanced H(2)O(2)-stimulated ERK phosphorylation, whereas preactivation of p38 MAPK with sodium arsenite reduced H(2)O(2)-stimulated ERK phosphorylation. sodium arsenite 162-177 mitogen-activated protein kinase 1 Homo sapiens 148-151 29479036-6 2018 Moreover, the combination prolonged the phosphorylation of mitogen-activated protein kinase (MAPK) members, including c-Jun-N-terminal kinase (JNK), p38, and extracellular signal related kinases (ERK), and increased intracellular reactive oxygen species (ROS), in comparison to treatment of NaAsO2 or TNF-alpha alone. sodium arsenite 291-297 mitogen-activated protein kinase 1 Homo sapiens 93-97 32278034-0 2020 PINK1/Parkin-mediated mitophagy is involved in NaAsO2-induced apoptosis of human hepatic cells through activation of ERK signaling. sodium arsenite 47-53 mitogen-activated protein kinase 1 Homo sapiens 117-120 32278034-8 2020 When the ERK signaling inhibitor PD98095 was used, there was a similar result that mitophagy was reduced though in contrast with CsA the apoptosis rate was also decreased compared with NaAsO2 alone. sodium arsenite 185-191 mitogen-activated protein kinase 1 Homo sapiens 9-12 32278034-9 2020 This result, along with the increased levels of ERK measured here in response to NaAsO2, indicates that ERK activation is a second key molecular response to NaAsO2 through the activation of both apoptosis and mitophagy. sodium arsenite 81-87 mitogen-activated protein kinase 1 Homo sapiens 48-51 32278034-9 2020 This result, along with the increased levels of ERK measured here in response to NaAsO2, indicates that ERK activation is a second key molecular response to NaAsO2 through the activation of both apoptosis and mitophagy. sodium arsenite 81-87 mitogen-activated protein kinase 1 Homo sapiens 104-107 32278034-9 2020 This result, along with the increased levels of ERK measured here in response to NaAsO2, indicates that ERK activation is a second key molecular response to NaAsO2 through the activation of both apoptosis and mitophagy. sodium arsenite 157-163 mitogen-activated protein kinase 1 Homo sapiens 48-51 32278034-9 2020 This result, along with the increased levels of ERK measured here in response to NaAsO2, indicates that ERK activation is a second key molecular response to NaAsO2 through the activation of both apoptosis and mitophagy. sodium arsenite 157-163 mitogen-activated protein kinase 1 Homo sapiens 104-107 32278034-11 2020 Mitophagy is increased in response to a secondary effect of NaAsO2 on ERK signaling that activates both mitophagy and apoptosis. sodium arsenite 60-66 mitogen-activated protein kinase 1 Homo sapiens 70-73 32278034-13 2020 When ERK signaling is inhibited by PD98095 both the levels of apoptosis and mitophagy are decreased compared with the response produced by NaAsO2 alone in comparison to the inhibition of mitophagy by CsA that reduced mitophagy but dramatically increased apoptosis in response. sodium arsenite 139-145 mitogen-activated protein kinase 1 Homo sapiens 5-8