PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35298964-0	2022	NaAsO2 decreases GSH synthesis by inhibiting GCLC and induces apoptosis through Hela cell mitochondrial damage, mediating the activation of the NF-kappaB/miR-21 signaling pathway.	sodium arsenite	0-6	nuclear factor kappa B subunit 1	Homo sapiens	144-153	
35298964-5	2022	However, the role of miR-21 in the mitochondrial pathway of cervical cancer cells induced by NaAsO2 through NF-kappaB/GCLC and GSH synthesis regulated oxidative stress is rarely reported.	sodium arsenite	93-99	nuclear factor kappa B subunit 1	Homo sapiens	108-117	
35298964-6	2022	Therefore, the purpose of this study was to investigate whether NaAsO2 might induce mitochondrial damage and apoptosis of cervical cancer cells through NF-kappaB/ miR-21 /GCLC induced oxidative stress, and play the anti-tumor role of arsenic as a potential drug for the treatment of cervical cancer.	sodium arsenite	64-70	nuclear factor kappa B subunit 1	Homo sapiens	152-161	
11835394-8	2002	The present results suggest that sodium arsenite stabilizes IkappaBalpha and prevents NF-kappaB activation in IL-1beta-stimulated Caco-2 cells independent of the heat shock response.	sodium arsenite	33-48	nuclear factor kappa B subunit 1	Homo sapiens	86-95	
19672740-3	2009	Investigating the responsible signalling cascades, it was found that NaAsO(2) administration activates mitogen-activated protein kinases (MAPKs) and NF-kappaB in oxidative stress mediated renal dysfunction and induced apoptotic cell death by the reciprocal regulation of Bcl-2/Bad in association with reducing mitochondrial membrane potential and increased cytosolic cytochrome C as well.	sodium arsenite	69-77	nuclear factor kappa B subunit 1	Homo sapiens	149-158	
12076508-1	2002	Both acute (24 h) and chronic (10-20 week) exposure of human fibroblast cells to low dose sodium arsenite (As(III)) significantly affects activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) DNA binding activity.	sodium arsenite	90-105	nuclear factor kappa B subunit 1	Homo sapiens	170-192	
12076508-1	2002	Both acute (24 h) and chronic (10-20 week) exposure of human fibroblast cells to low dose sodium arsenite (As(III)) significantly affects activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) DNA binding activity.	sodium arsenite	90-105	nuclear factor kappa B subunit 1	Homo sapiens	194-204	
28556958-0	2017	Downregulation of androgen receptors by NaAsO2 via inhibition of AKT-NF-kappaB and HSP90 in castration resistant prostate cancer.	sodium arsenite	40-46	nuclear factor kappa B subunit 1	Homo sapiens	69-78	
28556958-12	2017	NaAsO2 significantly inhibited phosphorylation of AKT and expression and nuclear translocation of NF-kappaB.	sodium arsenite	0-6	nuclear factor kappa B subunit 1	Homo sapiens	98-107	
16497974-8	2006	Sodium arsenite suppressed the constitutive NF-kappaB activation by preventing the IkappaB-alpha degradation and the nuclear translocation of NF-kappaB.	sodium arsenite	0-15	nuclear factor kappa B subunit 1	Homo sapiens	44-53	
16497974-8	2006	Sodium arsenite suppressed the constitutive NF-kappaB activation by preventing the IkappaB-alpha degradation and the nuclear translocation of NF-kappaB.	sodium arsenite	0-15	nuclear factor kappa B subunit 1	Homo sapiens	142-151	
16497974-10	2006	Sodium arsenite was shown to down-regulate the expression of survivin through the NF-kappaB pathway, thus inhibiting cell growth and promoting apoptosis of ATL cells.	sodium arsenite	0-15	nuclear factor kappa B subunit 1	Homo sapiens	82-91	
12241537-8	2002	When cells were transfected with a plasmid expressing the p65 subunit of NF-kappaB, the inhibitory effect of sodium arsenite on NF-kappaB activity and IL-6 production was blunted.	sodium arsenite	109-124	nuclear factor kappa B subunit 1	Homo sapiens	73-82	
12241537-9	2002	These results suggest that sodium arsenite inhibits IL-6 production in enterocytes subjected to an inflammatory stimulus, and that this effect, at least in part, reflects down-regulated NF-kappaB activity.	sodium arsenite	27-42	nuclear factor kappa B subunit 1	Homo sapiens	186-195	
11835394-1	2002	Recent studies suggest that sodium arsenite downregulates NF-kappaB activity by inhibiting phosphorylation and subsequent degradation of IkappaBalpha.	sodium arsenite	28-43	nuclear factor kappa B subunit 1	Homo sapiens	58-67