PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34221922-6	2021	The effects of NaAsO2 on the methylation of H3 in the promoter regions of 78 kDa glucose-regulated protein, activating transcription factor 4 and C/EBP-homologous protein were evaluated by chromatin immunoprecipitation assay.	sodium arsenite	15-21	activating transcription factor 4	Homo sapiens	108-141	
32506763-7	2020	Further results showed that NaAsO2 increased expression in biomarker of endoplasmic reticulum (ER) stress and activated the protein kinase R-like ER kinase (PERK)-eukaryotic translation initiation 2alpha (eIF2alpha)-activating transcription factor 4 (ATF4) pathway.	sodium arsenite	28-34	activating transcription factor 4	Homo sapiens	216-249	
32506763-7	2020	Further results showed that NaAsO2 increased expression in biomarker of endoplasmic reticulum (ER) stress and activated the protein kinase R-like ER kinase (PERK)-eukaryotic translation initiation 2alpha (eIF2alpha)-activating transcription factor 4 (ATF4) pathway.	sodium arsenite	28-34	activating transcription factor 4	Homo sapiens	251-255	
32506763-8	2020	PERK inhibitor and ATF4 siRNA significantly attenuated NaAsO2 -induced CHOP and DR5 expressions.	sodium arsenite	55-61	activating transcription factor 4	Homo sapiens	19-23	
32506763-10	2020	Taken together, the results indicate that ROS-mediated PERK-eIF2alpha-ATF4 pathway activated by NaAsO2 is the critical upstream event for subsequent apoptosis induction via regulating CHOP-DR5 signaling in L-02 cells when chronic exposure to arsenic, and support that antioxidants might be potential therapeutic agents for preventing or delaying the onset and progress of arsenic-induced hepatotoxicity.	sodium arsenite	96-102	activating transcription factor 4	Homo sapiens	70-74