PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26371860-3	2015	Our results showed that treatment with arsenic (sodium arsenite, 5, 10 and 20mg/kg, intra-gastrically) increased the expression of NRF2 and its downstream targets heme oxygenase-1 (HO-1), glutathione-S-transferase (GST), glutamate-cysteine ligase (GCL) and glutathione reductase (GR) consistently in spleen, thymus, as well as peripheral blood mononuclear cells (PBMCs), as early as treatment from 6h.	sodium arsenite	48-63	nuclear factor, erythroid derived 2, like 2	Mus musculus	131-135	
33884178-0	2021	Sodium arsenite induces spatial learning and memory impairment associated with oxidative stress and activates the Nrf2/PPARgamma pathway against oxidative injury in mice hippocampus.	sodium arsenite	0-15	nuclear factor, erythroid derived 2, like 2	Mus musculus	114-118	
33242462-5	2021	Moreover, NaAsO2 toxicity evoked exhaustion of antioxidant markers (SOD, CAT, GPx, GR, and GSH), down-regulation of Nrf2 (nuclear factor erythroid 2-related factor 2) gene expression level, and elevations in malondialdehyde.	sodium arsenite	10-16	nuclear factor, erythroid derived 2, like 2	Mus musculus	116-120	
33242462-5	2021	Moreover, NaAsO2 toxicity evoked exhaustion of antioxidant markers (SOD, CAT, GPx, GR, and GSH), down-regulation of Nrf2 (nuclear factor erythroid 2-related factor 2) gene expression level, and elevations in malondialdehyde.	sodium arsenite	10-16	nuclear factor, erythroid derived 2, like 2	Mus musculus	122-165	
27165637-3	2016	In the present study, mice were used as a model to investigate the oxidative stress levels and the expressions of NRF2-regulated antioxidant substances in both cerebral cortex and hippocampus with 5, 10 and 20 mg/kg NaAsO2 exposure intra-gastrically.	sodium arsenite	216-222	nuclear factor, erythroid derived 2, like 2	Mus musculus	114-118	
27165637-5	2016	We also detected rapidly elevation of NRF2 protein levels by enhancement of Nrf2 transcription, especially at 20 mg/kg NaAsO2 exposure group.	sodium arsenite	119-125	nuclear factor, erythroid derived 2, like 2	Mus musculus	38-42	
27165637-5	2016	We also detected rapidly elevation of NRF2 protein levels by enhancement of Nrf2 transcription, especially at 20 mg/kg NaAsO2 exposure group.	sodium arsenite	119-125	nuclear factor, erythroid derived 2, like 2	Mus musculus	76-80	
26473898-5	2015	Our results showed 10 mg/kg NaAsO2 elevated the NRF2 protein and increased the transcription of Nrf2 mRNA, as well as up-regulated NRF2 downstream targets HO-1, GST and GCLC time- and dose-dependently both in the liver and kidney.	sodium arsenite	28-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	48-52	
26473898-5	2015	Our results showed 10 mg/kg NaAsO2 elevated the NRF2 protein and increased the transcription of Nrf2 mRNA, as well as up-regulated NRF2 downstream targets HO-1, GST and GCLC time- and dose-dependently both in the liver and kidney.	sodium arsenite	28-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	96-100	
26473898-5	2015	Our results showed 10 mg/kg NaAsO2 elevated the NRF2 protein and increased the transcription of Nrf2 mRNA, as well as up-regulated NRF2 downstream targets HO-1, GST and GCLC time- and dose-dependently both in the liver and kidney.	sodium arsenite	28-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	131-135	
26066304-5	2015	The redox-sensitive transcription factors Nrf2 and the AP-1 component c-Jun were found to be up-regulated in NaAsO2-treated cells, and we demonstrated a specific NaAsO2-mediated increase of c-Jun and Nrf2 binding activity to the genomic region identified, supporting their putative involvement in CRYAB regulation following a shift in redox balance.	sodium arsenite	109-115	nuclear factor, erythroid derived 2, like 2	Mus musculus	42-46	
26066304-5	2015	The redox-sensitive transcription factors Nrf2 and the AP-1 component c-Jun were found to be up-regulated in NaAsO2-treated cells, and we demonstrated a specific NaAsO2-mediated increase of c-Jun and Nrf2 binding activity to the genomic region identified, supporting their putative involvement in CRYAB regulation following a shift in redox balance.	sodium arsenite	109-115	nuclear factor, erythroid derived 2, like 2	Mus musculus	200-204	
26066304-5	2015	The redox-sensitive transcription factors Nrf2 and the AP-1 component c-Jun were found to be up-regulated in NaAsO2-treated cells, and we demonstrated a specific NaAsO2-mediated increase of c-Jun and Nrf2 binding activity to the genomic region identified, supporting their putative involvement in CRYAB regulation following a shift in redox balance.	sodium arsenite	162-168	nuclear factor, erythroid derived 2, like 2	Mus musculus	42-46	
26066304-5	2015	The redox-sensitive transcription factors Nrf2 and the AP-1 component c-Jun were found to be up-regulated in NaAsO2-treated cells, and we demonstrated a specific NaAsO2-mediated increase of c-Jun and Nrf2 binding activity to the genomic region identified, supporting their putative involvement in CRYAB regulation following a shift in redox balance.	sodium arsenite	162-168	nuclear factor, erythroid derived 2, like 2	Mus musculus	200-204	
18404528-1	2008	Heme oxygenase-1 (HO-1) is markedly upregulated by sodium arsenite and previous studies implicated the transcriptional enhancers Nrf2 and AP-1 in arsenite-induced ho-1 gene expression in murine cells.	sodium arsenite	51-66	nuclear factor, erythroid derived 2, like 2	Mus musculus	129-133