PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35298964-10	2022	When Hela cells were treated with 15, 20, and 25 mumol/L NaAsO2, the mRNA and protein levels of GCLC and GCLM were reduced, the expression of p65 in the nucleus was increased, the expression of p-p65/p65, p-IkappaBalpha/IkappaBalpha and miR-21 were significantly increased.	sodium arsenite	57-63	microRNA 21	Homo sapiens	237-243	
35298964-0	2022	NaAsO2 decreases GSH synthesis by inhibiting GCLC and induces apoptosis through Hela cell mitochondrial damage, mediating the activation of the NF-kappaB/miR-21 signaling pathway.	sodium arsenite	0-6	microRNA 21	Homo sapiens	154-160	
35298964-5	2022	However, the role of miR-21 in the mitochondrial pathway of cervical cancer cells induced by NaAsO2 through NF-kappaB/GCLC and GSH synthesis regulated oxidative stress is rarely reported.	sodium arsenite	93-99	microRNA 21	Homo sapiens	21-27	
35298964-6	2022	Therefore, the purpose of this study was to investigate whether NaAsO2 might induce mitochondrial damage and apoptosis of cervical cancer cells through NF-kappaB/ miR-21 /GCLC induced oxidative stress, and play the anti-tumor role of arsenic as a potential drug for the treatment of cervical cancer.	sodium arsenite	64-70	microRNA 21	Homo sapiens	163-169	
35298964-12	2022	When BAY 11-7082 combined with NaAsO2 co-treated, compared with the NaAsO2 group, the protein and mRNA expression of GCLC was increased, NaAsO2-increased expression level of miR-21 was suppressed, and the DeltaPsim and cell viability were higher.	sodium arsenite	31-37	microRNA 21	Homo sapiens	174-180	
35298964-12	2022	When BAY 11-7082 combined with NaAsO2 co-treated, compared with the NaAsO2 group, the protein and mRNA expression of GCLC was increased, NaAsO2-increased expression level of miR-21 was suppressed, and the DeltaPsim and cell viability were higher.	sodium arsenite	137-143	microRNA 21	Homo sapiens	174-180	
35298964-13	2022	In addition, compared with the combination of NaAsO2 and miR-21NC, the protein expression of GCLC was increased, the DeltaPsim and cell viability reduction were alleviated by miR-21 Inhibitor combined with NaAsO2.	sodium arsenite	46-52	microRNA 21	Homo sapiens	175-181	
35298964-13	2022	In addition, compared with the combination of NaAsO2 and miR-21NC, the protein expression of GCLC was increased, the DeltaPsim and cell viability reduction were alleviated by miR-21 Inhibitor combined with NaAsO2.	sodium arsenite	206-212	microRNA 21	Homo sapiens	57-63