PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9219571-8	1997	The effect of treatment with sodium arsenite on PARP activity was assessed as follows: Molt-3 cells (a human T-cell lymphoma-derived cell line) in culture were treated for 24 h with concentrations of sodium arsenite ranging from 2.5 up to 25 microM.	sodium arsenite	29-44	poly(ADP-ribose) polymerase 1	Homo sapiens	48-52	
24100277-4	2014	The apoptosis induced by sodium meta-arsenite was associated with cleavage of caspases 3, 8, and 9, and poly (ADP-ribose) polymerase (PARP) and increased annexin V-positive cells, and was inhibited by the pan-caspase inhibitor Z-VAD-fmk.	sodium arsenite	25-45	poly(ADP-ribose) polymerase 1	Homo sapiens	78-132	
29479036-5	2018	Using HeLa cell model, we found that the combination of NaAsO2 and TNF-alpha clearly decreased cell viability and mitochondrial membrane potential, but increased percentage of early and late apoptotic cells and cleaved-poly (ADP-ribose) polymerase (PARP).	sodium arsenite	56-62	poly(ADP-ribose) polymerase 1	Homo sapiens	219-247	
29479036-5	2018	Using HeLa cell model, we found that the combination of NaAsO2 and TNF-alpha clearly decreased cell viability and mitochondrial membrane potential, but increased percentage of early and late apoptotic cells and cleaved-poly (ADP-ribose) polymerase (PARP).	sodium arsenite	56-62	poly(ADP-ribose) polymerase 1	Homo sapiens	249-253	
24100277-4	2014	The apoptosis induced by sodium meta-arsenite was associated with cleavage of caspases 3, 8, and 9, and poly (ADP-ribose) polymerase (PARP) and increased annexin V-positive cells, and was inhibited by the pan-caspase inhibitor Z-VAD-fmk.	sodium arsenite	25-45	poly(ADP-ribose) polymerase 1	Homo sapiens	134-138	
24100277-7	2014	Moreover, sodium meta-arsenite led to the accumulation of intracellular reactive oxygen species (ROS) and N-acetyl-L-cysteine (NAC), a ROS scavenger, decreased sodium meta-arsenite-induced levels of cleaved PARP and LC3-II.	sodium arsenite	10-30	poly(ADP-ribose) polymerase 1	Homo sapiens	207-211	
24100277-7	2014	Moreover, sodium meta-arsenite led to the accumulation of intracellular reactive oxygen species (ROS) and N-acetyl-L-cysteine (NAC), a ROS scavenger, decreased sodium meta-arsenite-induced levels of cleaved PARP and LC3-II.	sodium arsenite	160-180	poly(ADP-ribose) polymerase 1	Homo sapiens	207-211	
19536524-3	2009	NaAsO2 treatment (0-30 microM) was also found to induce phosphatidylserine externalization, a hallmark of apoptosis; to disrupt the mitochondrial membrane potential (Deltapsi ( m )); to cause the release of cytochrome c into the cytosol, and to trigger cleavage of caspase-3 and poly (ADP-ribose) polymerase (PARP) in a dose-dependent manner.	sodium arsenite	0-6	poly(ADP-ribose) polymerase 1	Homo sapiens	309-313	
20188806-3	2010	The results showed that folate deficiency significantly aggravated the NaAsO(2)-induced apoptotic progression [evidenced by phosphatidylserine externalization, cleavage of caspase-3 and poly (ADP-ribose) polymerase (PARP), collapse of mitochondrial potential, and release of cytochrome c from the mitochondria] and decrease of cell viability.	sodium arsenite	71-79	poly(ADP-ribose) polymerase 1	Homo sapiens	216-220