PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9219571-8 1997 The effect of treatment with sodium arsenite on PARP activity was assessed as follows: Molt-3 cells (a human T-cell lymphoma-derived cell line) in culture were treated for 24 h with concentrations of sodium arsenite ranging from 2.5 up to 25 microM. sodium arsenite 29-44 poly(ADP-ribose) polymerase 1 Homo sapiens 48-52 24100277-4 2014 The apoptosis induced by sodium meta-arsenite was associated with cleavage of caspases 3, 8, and 9, and poly (ADP-ribose) polymerase (PARP) and increased annexin V-positive cells, and was inhibited by the pan-caspase inhibitor Z-VAD-fmk. sodium arsenite 25-45 poly(ADP-ribose) polymerase 1 Homo sapiens 78-132 29479036-5 2018 Using HeLa cell model, we found that the combination of NaAsO2 and TNF-alpha clearly decreased cell viability and mitochondrial membrane potential, but increased percentage of early and late apoptotic cells and cleaved-poly (ADP-ribose) polymerase (PARP). sodium arsenite 56-62 poly(ADP-ribose) polymerase 1 Homo sapiens 219-247 29479036-5 2018 Using HeLa cell model, we found that the combination of NaAsO2 and TNF-alpha clearly decreased cell viability and mitochondrial membrane potential, but increased percentage of early and late apoptotic cells and cleaved-poly (ADP-ribose) polymerase (PARP). sodium arsenite 56-62 poly(ADP-ribose) polymerase 1 Homo sapiens 249-253 24100277-4 2014 The apoptosis induced by sodium meta-arsenite was associated with cleavage of caspases 3, 8, and 9, and poly (ADP-ribose) polymerase (PARP) and increased annexin V-positive cells, and was inhibited by the pan-caspase inhibitor Z-VAD-fmk. sodium arsenite 25-45 poly(ADP-ribose) polymerase 1 Homo sapiens 134-138 24100277-7 2014 Moreover, sodium meta-arsenite led to the accumulation of intracellular reactive oxygen species (ROS) and N-acetyl-L-cysteine (NAC), a ROS scavenger, decreased sodium meta-arsenite-induced levels of cleaved PARP and LC3-II. sodium arsenite 10-30 poly(ADP-ribose) polymerase 1 Homo sapiens 207-211 24100277-7 2014 Moreover, sodium meta-arsenite led to the accumulation of intracellular reactive oxygen species (ROS) and N-acetyl-L-cysteine (NAC), a ROS scavenger, decreased sodium meta-arsenite-induced levels of cleaved PARP and LC3-II. sodium arsenite 160-180 poly(ADP-ribose) polymerase 1 Homo sapiens 207-211 19536524-3 2009 NaAsO2 treatment (0-30 microM) was also found to induce phosphatidylserine externalization, a hallmark of apoptosis; to disrupt the mitochondrial membrane potential (Deltapsi ( m )); to cause the release of cytochrome c into the cytosol, and to trigger cleavage of caspase-3 and poly (ADP-ribose) polymerase (PARP) in a dose-dependent manner. sodium arsenite 0-6 poly(ADP-ribose) polymerase 1 Homo sapiens 309-313 20188806-3 2010 The results showed that folate deficiency significantly aggravated the NaAsO(2)-induced apoptotic progression [evidenced by phosphatidylserine externalization, cleavage of caspase-3 and poly (ADP-ribose) polymerase (PARP), collapse of mitochondrial potential, and release of cytochrome c from the mitochondria] and decrease of cell viability. sodium arsenite 71-79 poly(ADP-ribose) polymerase 1 Homo sapiens 216-220