PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21408196-7 2011 Importantly, we show that Ca2+ entry via Orai1 triggers plasma membrane insertion of TRPC1, which is prevented by blocking SOCE with 1 microM Gd3+, removal of extracellular Ca2+, knockdown of Orai1, or expression of dominant negative mutant Orai1 lacking a functional pore, Orai1-E106Q. ganglioside, GD3 142-146 transient receptor potential cation channel subfamily C member 1 Homo sapiens 85-90 33713955-7 2021 Meanwhile, similar to the blocking effect of the specific SOC inhibitors Gd3+ and La3+ on LPS-induced calcium influx, RNAi-mediated depletion of STIM1 or the SOC proteins TRPC1 and ORAI1 could significantly inhibit serum or LPS-induced extracellular calcium influx, as well as the expression of the inflammatory cytokines tumor necrosis factor, intercellular cell adhesion molecule-1, and endothelin-1. ganglioside, GD3 73-77 transient receptor potential cation channel subfamily C member 1 Homo sapiens 171-176