PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34273398-6	2021	Use of the SHP2 inhibitors, SHP099 and RMC-4550, resulted in inhibition of cell growth in ALK-driven NB cells.	RMC-4550	39-47	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	11-15	
32586982-5	2020	Here we report inhibition of growth and downstream RAS-MAPK signaling in neuroblastoma cells in response to treatment with the SHP2 inhibitors SHP099, II-B08, and RMC-4550.	RMC-4550	163-171	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	127-131	
31043123-3	2020	RMC-4550, as a newly developed selective inhibitor of SHP2, possesses an overwhelming advantage over the previous generation inhibitor SHP099 in terms of in vitro activity.	RMC-4550	0-8	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	54-58	
31043123-4	2020	However, the binding mode of SHP2 with RMC-4550 and the reason for the high efficiency of RMC-4550 as SHP2 inhibitor at molecular level are still unclear.	RMC-4550	39-47	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	29-33	
31043123-4	2020	However, the binding mode of SHP2 with RMC-4550 and the reason for the high efficiency of RMC-4550 as SHP2 inhibitor at molecular level are still unclear.	RMC-4550	90-98	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	102-106	
31043123-5	2020	Therefore, in this study, the binding mode of RMC-4550 with SHP2 and the superiorities of RMC-4550 as inhibitor at binding affinity and dynamic interactive behavior with SHP2 were probed by molecular docking and molecular dynamics (MD) simulations.	RMC-4550	46-54	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	60-64	
31043123-5	2020	Therefore, in this study, the binding mode of RMC-4550 with SHP2 and the superiorities of RMC-4550 as inhibitor at binding affinity and dynamic interactive behavior with SHP2 were probed by molecular docking and molecular dynamics (MD) simulations.	RMC-4550	90-98	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	170-174