PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31115488-2 2019 Mutated PMM2 leads to the reduced conversion of mannose-6-P to mannose-1-P, which results in low concentration levels of guanosine 5"-diphospho-D-mannose (GDP-Man), a nucleotide-activated sugar essential for the construction of protein oligosaccharide chains. GDP-D-mannose disodium salt 155-162 phosphomannomutase 2 Homo sapiens 8-12 31115488-3 2019 In the present study, an in vitro therapeutic approach was used, based on GDP-Man-loaded poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles (NPs), which were used to treat CDG-Ia fibroblast cultures, thus bypassing the glycosylation pathway reaction catalysed by PMM2. GDP-D-mannose disodium salt 74-81 phosphomannomutase 2 Homo sapiens 265-269