PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11543641-4	2001	In HL-60 cells, the general caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp fluoromethyl ketone (Z-VAD.FMK) blocked activation of caspases-3/-7, cleavage of PARP, and DNA, but PS externalization and cytoplasmic changes were not significantly affected.	Caspase Inhibitor VI	46-95	poly(ADP-ribose) polymerase 1	Homo sapiens	157-161	
11393284-7	2001	The increased cell death, early caspase-3 activation and PARP cleavage, and flow cytometric changes seen in pro-caspase-3-expressing cells can be partially inhibited by treatment with benzyloxycarbonyl-val-ala-asp fluoromethylketone, a synthetic caspase inhibitor.	Caspase Inhibitor VI	184-232	poly(ADP-ribose) polymerase 1	Homo sapiens	57-61	
10075737-5	1999	Pretreatment with the pan-caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone (Z-VAD-fmk) inhibited PARP cleavage, DNA fragmentation, calpain activation, and Bax cleavage and increased cell survival by 40%.	Caspase Inhibitor VI	44-92	poly(ADP-ribose) polymerase 1	Homo sapiens	115-119	
10462048-4	1999	Pre-treatment with the caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp fluoromethyl ketone (Z-VAD.FMK) blocked apoptosis and the resultant cleavage of these caspases and PARP.	Caspase Inhibitor VI	41-90	poly(ADP-ribose) polymerase 1	Homo sapiens	170-174	
10085120-4	1999	The caspase inhibitors benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone (zVAD-fmk) and benzyloxycarbonyl-Asp-Glu-Val-Asp-fluoromethylketone (zDEVD-fmk) protect cells against apoptosis and inhibit DEVD-specific caspase activity and PARP cleavage without affecting JNK1 and p38 MAPK activations.	Caspase Inhibitor VI	23-71	poly(ADP-ribose) polymerase 1	Homo sapiens	231-235	
10430095-7	1999	The induction of apoptosis, activation of caspase 3, and poly(ADP-ribose) polymerase cleavage in treatment regimens with paclitaxel and paclitaxel followed by flavopiridol were reversed by treatment with the caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone, which supports the notion that caspases are the executioners of apoptosis in these processes.	Caspase Inhibitor VI	226-274	poly(ADP-ribose) polymerase 1	Homo sapiens	57-84	
9288794-6	1997	Drug-induced apoptosis involved activation of caspases (interleukin 1beta-converting enzyme/Ced-3-like proteases) and processing of the prototype caspase substrate PARP and was completely blocked by benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone, a peptide inhibitor of caspases.	Caspase Inhibitor VI	199-248	poly(ADP-ribose) polymerase 1	Homo sapiens	164-168