PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26411703-0 2015 Inhibition of cyclin-dependent kinase CDK1 by oxindolimine ligands and corresponding copper and zinc complexes. Copper 85-91 cyclin dependent kinase 1 Homo sapiens 38-42 22077320-4 2011 The downregulation of CDC2, CCNB1, TPX2, AURKA, and AURKB, the expressions of which are involved in cell cycle arrest, was attributed to Cu ions released from CuO-NPs into medium. Copper 137-139 cyclin dependent kinase 1 Homo sapiens 22-26 25579846-4 2015 By using two mutually compatible, bioorthogonal reactions (copper-catalyzed azide-alkyne cycloaddition chemistry and TCO-tetrazine ligation), we demostrate small molecule-based multiplex bioimaging for simultaneous in situ monitoring of two important cell-cycle regulating kinases (AKA and CDK1). Copper 59-65 cyclin dependent kinase 1 Homo sapiens 290-294 11750022-5 2002 All [(dien)Cu(B)NO(3))](NO(3)) complexes had an activity against colon cancer cells (HT-29), inducing G2/M cell cycle arrest, an effect that for most of the complexes could be attributed to p34cdc2 inhibition by tyrosine-phosphorylation and/or to induction of (cyclin-dependent kinase inhibitor) p21(WAF1). Copper 11-13 cyclin dependent kinase 1 Homo sapiens 190-197