PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7248954-0 1981 Copper- and zinc-containing superoxide dismutase and manganese-containing superoxide dismutase in human tissues and human malignant tumors. Copper 0-6 superoxide dismutase 2 Homo sapiens 53-94 31273612-4 2019 Quantitative real time PCR (qRT-PCR) was employed to evaluate the effects of Cd and Cu on the expression of cytosolic hsp70 and Mn-sod genes. Copper 84-86 superoxide dismutase 2 Homo sapiens 128-134 28100855-9 2016 Manganese, copper and zinc are a part of the group of superoxide dismutase enzymes (MnSOD, Cu/ZnSOD), which catalyse the superoxide anion dismutation into hydrogen peroxide and oxygen. Copper 11-17 superoxide dismutase 2 Homo sapiens 84-89 19616630-6 2009 Mn-SOD expression in the liver and kidney were significantly modulated by injection of LPS (1, 5, or 10 microg g(-1) body weight), Edwardsiella tarda challenge (5 x 10(3) or 5 x 10(5) cells/fish), and heavy metal exposure (Cd, Cu, or Zn at 5 microM). Copper 227-229 superoxide dismutase 2 Homo sapiens 0-6 17602958-8 2007 The Fe-substituted enzyme showed a hydrogen-peroxide-mediated radical-generating activity, which was monitored by a cation radical of 2,2"-azinobis-(3-ethylbenzthiazoline-6-sulfonate) formation similar to that of Cu,ZnSOD, but native human MnSOD and FeSOD showed no radical-generation ability. Copper 213-215 superoxide dismutase 2 Homo sapiens 240-245 15977906-5 2005 Inhibitor studies with purified recombinant Cu/ ZnSOD and MnSOD, both of which were functionally expressed in Escherichia coli, confirmed that they are copper/zinc and manganese-containing SOD, respectively. Copper 152-158 superoxide dismutase 2 Homo sapiens 58-63 14531733-11 2004 It is possible that a deficiency of zinc in the low-copper diet may be primarily involved in MnSOD induction. Copper 52-58 superoxide dismutase 2 Homo sapiens 93-98 10692109-1 2000 On the basis of our recent observation that copper, zinc-superoxide dismutase and manganese-superoxide dismutase change differently following a single exposure to ultraviolet-B irradiation in the human keratinocyte cell line HaCaT, we have examined the possible role of endogenous copper,zinc-superoxide dismutase or manganese-superoxide dismutase against ultraviolet-B-induced reactive-oxygen- species-mediated keratinocyte injury in vitro. Copper 44-50 superoxide dismutase 2 Homo sapiens 317-347 10352126-6 1999 Manganese superoxide dismutase (MnSOD) content was also increased 49% overall in the cells grown in the absence of supplemental copper. Copper 128-134 superoxide dismutase 2 Homo sapiens 32-37 10352126-8 1999 These findings indicate that in cells grown under conditions of copper deprivation that suppress cytochrome-c oxidase activity, oxidative stress in mitochondria is increased sufficiently to induce MnSOD, potentiate protein oxidation, and possibly cause the oxidative inactivation of complex I. Copper 64-70 superoxide dismutase 2 Homo sapiens 197-202 10222400-2 1999 Altered amounts of copper-zinc (CuZnSOD) and manganese (MnSOD) superoxide dismutases have been implicated in multistage carcinogesis of both rodents and humans. Copper 19-25 superoxide dismutase 2 Homo sapiens 56-61 7493040-2 1995 Skin is endowed with antioxidant enzymes including superoxide dismutases (SOD): cytosolic copper zinc SOD and mitochondrial manganese SOD. Copper 90-96 superoxide dismutase 2 Homo sapiens 74-77 7856748-9 1995 In senile plaques, copper, zinc-superoxide dismutase-positive globular structures were surrounded by astrocytes highly enriched in manganese-superoxide dismutase. Copper 19-25 superoxide dismutase 2 Homo sapiens 131-161 8317554-3 1993 Basal activity of copper-zinc SOD, and manganese SOD showed little variation with age. Copper 18-24 superoxide dismutase 2 Homo sapiens 30-33 1582797-2 1992 Biochemical and immunochemical techniques were used to compare levels of copper-zinc- and manganese-containing forms of SOD (CuZn-SOD and Mn-SOD) in human adult and fetal RPE cells. Copper 73-79 superoxide dismutase 2 Homo sapiens 120-123 1793616-1 1991 Manganese-superoxide dismutase (MnSOD) in human fibroblast and liver lysates was found to bind copper avidly under the conditions of a copper blotting technique which also detects known copper-binding proteins. Copper 95-101 superoxide dismutase 2 Homo sapiens 32-37 1793616-0 1991 Human manganese superoxide dismutase is readily detectable by a copper blotting technique. Copper 64-70 superoxide dismutase 2 Homo sapiens 6-36 1793616-1 1991 Manganese-superoxide dismutase (MnSOD) in human fibroblast and liver lysates was found to bind copper avidly under the conditions of a copper blotting technique which also detects known copper-binding proteins. Copper 95-101 superoxide dismutase 2 Homo sapiens 0-30 1793616-1 1991 Manganese-superoxide dismutase (MnSOD) in human fibroblast and liver lysates was found to bind copper avidly under the conditions of a copper blotting technique which also detects known copper-binding proteins. Copper 135-141 superoxide dismutase 2 Homo sapiens 0-30 1793616-1 1991 Manganese-superoxide dismutase (MnSOD) in human fibroblast and liver lysates was found to bind copper avidly under the conditions of a copper blotting technique which also detects known copper-binding proteins. Copper 135-141 superoxide dismutase 2 Homo sapiens 32-37 1793616-1 1991 Manganese-superoxide dismutase (MnSOD) in human fibroblast and liver lysates was found to bind copper avidly under the conditions of a copper blotting technique which also detects known copper-binding proteins. Copper 135-141 superoxide dismutase 2 Homo sapiens 0-30 1793616-1 1991 Manganese-superoxide dismutase (MnSOD) in human fibroblast and liver lysates was found to bind copper avidly under the conditions of a copper blotting technique which also detects known copper-binding proteins. Copper 135-141 superoxide dismutase 2 Homo sapiens 32-37 1793616-3 1991 Copper blotting provides a sensitive way to detect MnSOD in human tissues, and may be generally applicable to studies of copper-binding by biological molecules. Copper 0-6 superoxide dismutase 2 Homo sapiens 51-56 1793616-3 1991 Copper blotting provides a sensitive way to detect MnSOD in human tissues, and may be generally applicable to studies of copper-binding by biological molecules. Copper 121-127 superoxide dismutase 2 Homo sapiens 51-56 1648113-1 1991 A method for copper- and manganese-containing superoxide dismutase (Cu- and MnSOD) assay in tissue homogenates such as liver and brain, based on the measurement of the longitudinal nuclear relaxation time (T1) of F-, has been developed as a preliminary approach to in vivo measurement of these enzymes. Copper 13-19 superoxide dismutase 2 Homo sapiens 68-81 2060854-3 1991 At subcellular level, evidence for the participation of peroxisomal SOD in the molecular mechanism of plant tolerance to Cu is presented, and the activated oxygen-dependent toxicity of a xenobiotic (clofibrate) in plant peroxisomes is examined. Copper 121-123 superoxide dismutase 2 Homo sapiens 68-71 4061626-1 1985 Radioimmunoassays for both human copper-zinc and manganous superoxide dismutases (Cu-Zn SOD and Mn SOD, respectively) have been developed, validated, and utilized to measure the concentrations of these enzymes in cultured monocytes. Copper 33-39 superoxide dismutase 2 Homo sapiens 96-102 6316150-1 1983 Copper, zinc superoxide dismutase (SOD) catalyses the very rapid two-step dismutation of the toxic superoxide radical (O-2) to molecular oxygen and hydrogen peroxide through the alternate reduction and oxidation of the active-site copper. Copper 0-6 superoxide dismutase 2 Homo sapiens 35-38 6316150-1 1983 Copper, zinc superoxide dismutase (SOD) catalyses the very rapid two-step dismutation of the toxic superoxide radical (O-2) to molecular oxygen and hydrogen peroxide through the alternate reduction and oxidation of the active-site copper. Copper 231-237 superoxide dismutase 2 Homo sapiens 35-38