PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34764459-4	2022	Indeed, the traditional view of copper as solely an active site metabolic cofactor has been challenged by emerging evidence that copper is also a dynamic signalling metal and metalloallosteric regulator, such as for copper-dependent phosphodiesterase 3B (PDE3B) in lipolysis, mitogen-activated protein kinase kinase 1 (MEK1) and MEK2 in cell growth and proliferation and the kinases ULK1 and ULK2 in autophagy.	Copper	32-38	unc-51 like autophagy activating kinase 2	Homo sapiens	392-396	
34764459-4	2022	Indeed, the traditional view of copper as solely an active site metabolic cofactor has been challenged by emerging evidence that copper is also a dynamic signalling metal and metalloallosteric regulator, such as for copper-dependent phosphodiesterase 3B (PDE3B) in lipolysis, mitogen-activated protein kinase kinase 1 (MEK1) and MEK2 in cell growth and proliferation and the kinases ULK1 and ULK2 in autophagy.	Copper	129-135	unc-51 like autophagy activating kinase 2	Homo sapiens	392-396	
32420529-3	2020	(Nat Cell Biol, doi: 10.1038/s41556-020-0481-4) demonstrate that copper binds with high affinity to a designated interaction site in the pro-autophagic kinases ULK1 and ULK2.	Copper	65-71	unc-51 like autophagy activating kinase 2	Homo sapiens	169-173	
32203415-0	2020	Copper is an essential regulator of the autophagic kinases ULK1/2 to drive lung adenocarcinoma.	Copper	0-6	unc-51 like autophagy activating kinase 2	Homo sapiens	59-65	
32203415-2	2020	Here, we found that Cu is required for the activity of the autophagic kinases ULK1 and ULK2 (ULK1/2) through a direct Cu-ULK1/2 interaction.	Copper	20-22	unc-51 like autophagy activating kinase 2	Homo sapiens	87-91	
32203415-2	2020	Here, we found that Cu is required for the activity of the autophagic kinases ULK1 and ULK2 (ULK1/2) through a direct Cu-ULK1/2 interaction.	Copper	20-22	unc-51 like autophagy activating kinase 2	Homo sapiens	93-99	
32203415-2	2020	Here, we found that Cu is required for the activity of the autophagic kinases ULK1 and ULK2 (ULK1/2) through a direct Cu-ULK1/2 interaction.	Copper	20-22	unc-51 like autophagy activating kinase 2	Homo sapiens	121-127	
32203415-2	2020	Here, we found that Cu is required for the activity of the autophagic kinases ULK1 and ULK2 (ULK1/2) through a direct Cu-ULK1/2 interaction.	Copper	118-120	unc-51 like autophagy activating kinase 2	Homo sapiens	87-91	
32203415-2	2020	Here, we found that Cu is required for the activity of the autophagic kinases ULK1 and ULK2 (ULK1/2) through a direct Cu-ULK1/2 interaction.	Copper	118-120	unc-51 like autophagy activating kinase 2	Homo sapiens	93-99	
32203415-2	2020	Here, we found that Cu is required for the activity of the autophagic kinases ULK1 and ULK2 (ULK1/2) through a direct Cu-ULK1/2 interaction.	Copper	118-120	unc-51 like autophagy activating kinase 2	Homo sapiens	121-127