PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35605662-0 2022 Selective PPARdelta agonist seladelpar suppresses bile acid synthesis by reducing hepatocyte CYP7A1 via the fibroblast growth factor 21 signaling pathway. Seladelpar 28-38 fibroblast growth factor 21 Mus musculus 108-135 35605662-5 2022 In addition, seladelpar upregulated fibroblast growth factor 21 (Fgf21) in mouse liver, serum, and in cultured hepatocytes. Seladelpar 13-23 fibroblast growth factor 21 Mus musculus 36-63 35605662-5 2022 In addition, seladelpar upregulated fibroblast growth factor 21 (Fgf21) in mouse liver, serum, and in cultured hepatocytes. Seladelpar 13-23 fibroblast growth factor 21 Mus musculus 65-70 35605662-7 2022 The suppressive effect of seladelpar on Cyp7a1 expression was blocked by a JNK inhibitor as well as in the absence of Fgf21, indicating that Fgf21 plays an indispensable role in PPARdelta-mediated downregulation of Cyp7a1. Seladelpar 26-36 fibroblast growth factor 21 Mus musculus 141-146