PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35605662-0 2022 Selective PPARdelta agonist seladelpar suppresses bile acid synthesis by reducing hepatocyte CYP7A1 via the fibroblast growth factor 21 signaling pathway. Seladelpar 28-38 peroxisome proliferator activator receptor delta Mus musculus 10-19 35605662-7 2022 The suppressive effect of seladelpar on Cyp7a1 expression was blocked by a JNK inhibitor as well as in the absence of Fgf21, indicating that Fgf21 plays an indispensable role in PPARdelta-mediated downregulation of Cyp7a1. Seladelpar 26-36 peroxisome proliferator activator receptor delta Mus musculus 178-187 29404484-3 2017 Seladelpar (MBX-8025), a selective PPAR-delta agonist, improves atherogenic dyslipidemia. Seladelpar 0-10 peroxisome proliferator activator receptor delta Mus musculus 35-45 32553670-0 2021 The selective PPAR-delta agonist seladelpar reduces ethanol-induced liver disease by restoring gut barrier function and bile acid homeostasis in mice. Seladelpar 33-43 peroxisome proliferator activator receptor delta Mus musculus 14-24 32553670-3 2021 Here, we evaluated the effect of the selective PPAR-delta agonist seladelpar (MBX-8025) on gut barrier function and bile acid metabolism in a mouse model of ethanol-induced liver disease. Seladelpar 66-76 peroxisome proliferator activator receptor delta Mus musculus 47-57 32553670-11 2021 Data from this study demonstrates that seladelpar prevents and treats ethanol-induced liver damage in mice by direct PPARdelta agonism in both the liver and the intestine. Seladelpar 39-49 peroxisome proliferator activator receptor delta Mus musculus 117-126 29404484-0 2017 The selective peroxisome proliferator-activated receptor-delta agonist seladelpar reverses nonalcoholic steatohepatitis pathology by abrogating lipotoxicity in diabetic obese mice. Seladelpar 71-81 peroxisome proliferator activator receptor delta Mus musculus 14-62