PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20032969-5 2010 Methyl-6-phenylethynyl-pyridine (MPEP), an antagonist of the mGluR5 metabotropic glutamate receptor, blocks aberrant phenotypes in the Fmr1 mouse model of Fragile X, a comorbid neurodevelopmental disorder with autistic features. MPEP 33-37 fragile X messenger ribonucleoprotein 1 Mus musculus 135-139 21181121-8 2011 Furthermore, systemic administration of the selective group 1 mGlu5 antagonist 2-methyl-6-phenylethynyl pyridine (MPEP) reduced the average spine length and density in the cortical neurons of Fmr1 KO mice at developmental age. MPEP 114-118 fragile X messenger ribonucleoprotein 1 Mus musculus 192-196 21181121-12 2011 CONCLUSION: These results show that MPEP administration could partially rescue the morphological deficits of dendritic spines in Fmr1 KO mice at developmental age. MPEP 36-40 fragile X messenger ribonucleoprotein 1 Mus musculus 129-133