PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24732966-9 2014 Relative to controls, DIO increased (and CR decreased) the number of colon tumors (p = 0.01), cytokines (p<0.001), IGF-1 (p = 0.01), and proliferation (p<0.001). 3,3'-Dioctadecyloxacarbocyanine perchlorate 22-25 insulin-like growth factor 1 Mus musculus 118-123 24732966-12 2014 We conclude that the enhancing effects of DIO and suppressive effects of CR on colon carcinogenesis are associated with alterations in several biological pathways, including inflammation, IGF-1, and microRNAs. 3,3'-Dioctadecyloxacarbocyanine perchlorate 42-45 insulin-like growth factor 1 Mus musculus 188-193 23152442-9 2013 While the anticancer effects of CR were largely IGF1-dependent, the procancer effects of DIO manifested only when circulating IGF1 levels were low. 3,3'-Dioctadecyloxacarbocyanine perchlorate 89-92 insulin-like growth factor 1 Mus musculus 126-130