PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34156680-11 2021 Intraperitoneal injection 30 mg/kg of TEPP-46 significantly inhibited the development of MCD diet-induced NASH, alleviated the pathological changes in the liver, improved liver function, promoted the expression of the PKM2 tetramer in KCs, and inhibited the expression of HIF-1alpha and NLRP3. TEPP-46 38-45 NLR family, pyrin domain containing 3 Mus musculus 287-292 32323562-0 2020 PKM2 Activator TEPP-46 Attenuates Thoracic Aortic Aneurysm and Dissection by Inhibiting NLRP3 Inflammasome-Mediated IL-1beta Secretion. TEPP-46 15-22 NLR family, pyrin domain containing 3 Mus musculus 88-93 32323562-7 2020 Furthermore, TEPP-46 treatment also suppressed the activation of the NOD-like receptor (NLR) family and pyrin domain-containing protein 3 (NLRP3) inflammasome by downregulating p-STAT3 and HIF1-alpha. TEPP-46 13-20 NLR family, pyrin domain containing 3 Mus musculus 139-144