PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29662081-6	2018	We validated the assay by testing two small molecules, SAHA and RITA, reported to impair the E6-mediated p53 degradation.	Polyurethane Y-290	93-95	tumor protein p53	Homo sapiens	105-108	
9497376-4	1998	In vitro studies have shown that E6AP can form a high energy thiolester bond with ubiquitin and, in the presence of E6, transfer ubiquitin to p53.	Polyurethane Y-290	33-35	tumor protein p53	Homo sapiens	142-145	
7845670-8	1995	In both assays, complex formation with E6 was mediated through the amino-terminal 345 amino acids of p53 without a specific requirement for its C-terminus.	Polyurethane Y-290	39-41	tumor protein p53	Homo sapiens	101-104	
33796223-3	2021	E6 effects this oncogenic phenotype in part through inhibitory protein-protein interactions (PPIs) and accelerated degradation of proteins with tumor suppressor properties, such as p53 and caspase 8.	Polyurethane Y-290	0-2	tumor protein p53	Homo sapiens	181-184	
18528468-6	2006	In the presence of E6, E6AP catalyses the ubiquitylation and proteolysis of p53.	Polyurethane Y-290	19-21	tumor protein p53	Homo sapiens	76-79	
34202736-3	2021	E6 induces anti-apoptosis by degrading tumor suppressor proteins p53 (p53) via E6-E6-associated protein (E6AP)-mediated polyubiquitination.	Polyurethane Y-290	0-2	tumor protein p53	Homo sapiens	65-68	
34202736-3	2021	E6 induces anti-apoptosis by degrading tumor suppressor proteins p53 (p53) via E6-E6-associated protein (E6AP)-mediated polyubiquitination.	Polyurethane Y-290	0-2	tumor protein p53	Homo sapiens	70-73	
33984442-4	2021	To verify the biological effects of E6 polymorphisms towards p53 degradation, HPV16-E6 prototype and 7 variants isolated from cervical cancer biopsies of Moroccan women were evaluated for their activities by transient expression assays using pcDNA3.1-E6 constructs in C33A cell line.	Polyurethane Y-290	36-38	tumor protein p53	Homo sapiens	61-64	
31492752-2	2019	To examine the biochemical reaction in vitro, we established an efficient reconstitution system for the polyubiquitination of p53 by the E6AP-E6 complex.	Polyurethane Y-290	137-139	tumor protein p53	Homo sapiens	126-129	
26794656-6	2016	Both compounds clearly inhibited the ability of E6 to bind in vitro to both caspase 8 and E6AP, the protein that mediates p53 degradation.	Polyurethane Y-290	48-50	tumor protein p53	Homo sapiens	122-125