PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27915043-11 2017 Additionally, striatal brain-derived neurotrophic factor (BDNF), proBDNF and tyrosine hydroxylase (TH) levels of 6-OHDA-lesioned rats were decreased, while the tropomyosin-related kinase B (TrkB) levels were increased. Oxidopamine 113-119 tyrosine hydroxylase Rattus norvegicus 77-97 27844282-5 2017 Tyrosine hydroxylase (TH) immunostaining revealed a significant decrease of the TH-immunopositive striatal volume in 6-OHDA group from rostral to caudal one. Oxidopamine 117-123 tyrosine hydroxylase Rattus norvegicus 0-20 28504195-5 2017 Further study of the 6-OHDA-induced PD rat model indicated that FGF18 improved the behavioral dysfunction in PD rats and reduced the tyrosine hydroxylase (TH)-positive neuronal loss in the SN. Oxidopamine 21-27 tyrosine hydroxylase Rattus norvegicus 133-153 28504195-5 2017 Further study of the 6-OHDA-induced PD rat model indicated that FGF18 improved the behavioral dysfunction in PD rats and reduced the tyrosine hydroxylase (TH)-positive neuronal loss in the SN. Oxidopamine 21-27 tyrosine hydroxylase Rattus norvegicus 155-157 28504195-6 2017 In addition, 6-OHDA induced a loss of TH-positive fibers that was reversed by pretreatment with FGF18. Oxidopamine 13-19 tyrosine hydroxylase Rattus norvegicus 38-40 28611572-8 2017 The therapeutic effect of 4R was also reflected by decreased depletion of tyrosine hydroxylase (TH) in the striatum and substantia nigra (SN) on the side injected with 6-OHDA. Oxidopamine 168-174 tyrosine hydroxylase Rattus norvegicus 74-94 28247332-7 2017 The numbers of TH-positive neurons in the 6-OHDA-injected lesioned substantia nigra (SN) decreased significantly compared with the Sham group. Oxidopamine 42-48 tyrosine hydroxylase Rattus norvegicus 15-17 27915043-11 2017 Additionally, striatal brain-derived neurotrophic factor (BDNF), proBDNF and tyrosine hydroxylase (TH) levels of 6-OHDA-lesioned rats were decreased, while the tropomyosin-related kinase B (TrkB) levels were increased. Oxidopamine 113-119 tyrosine hydroxylase Rattus norvegicus 99-101 25999268-4 2015 Additionally, a protective effect was observed following repeated intranasal administration in 6-OHDA lesioned rats, as suggested by: a significant decrease in d-amphetamine-induced rotation at 2 weeks; a decrease in DA turnover in the lesioned striatum; and an increased sparing of tyrosine hydroxylase (TH) positive (+) neurons in a specific sub-region of the lesioned substantia nigra pars compacta (SNpc). Oxidopamine 95-101 tyrosine hydroxylase Rattus norvegicus 283-303 28004763-5 2016 PC12 cells treated with the neurotoxin 6-hydroxydopamine displayed increased TH levels in the mitochondrial fraction, while incubation of isolated mitochondria with TH led to a decrease in the mitochondrial membrane potential. Oxidopamine 39-56 tyrosine hydroxylase Rattus norvegicus 77-79 25999268-4 2015 Additionally, a protective effect was observed following repeated intranasal administration in 6-OHDA lesioned rats, as suggested by: a significant decrease in d-amphetamine-induced rotation at 2 weeks; a decrease in DA turnover in the lesioned striatum; and an increased sparing of tyrosine hydroxylase (TH) positive (+) neurons in a specific sub-region of the lesioned substantia nigra pars compacta (SNpc). Oxidopamine 95-101 tyrosine hydroxylase Rattus norvegicus 305-307 25230286-0 2014 Intraventricular injection of 6-hydroxydopamine results in an increased number of tyrosine hydroxylase immune-positive cells in the rat cortex. Oxidopamine 30-47 tyrosine hydroxylase Rattus norvegicus 82-102 25230286-2 2014 To find out if these cells express tyrosine hydroxylase (TH), the rate-limiting enzyme in the catecholamine synthesis pathway, we performed immunohistochemistry in the rat cortex following intraventricular injection of 6-OHDA. Oxidopamine 219-225 tyrosine hydroxylase Rattus norvegicus 35-55 24297323-4 2014 In association with >80% TH loss, we observed a significant decrease in glutamate uptake in the established 6-hydroxydopamine (6-OHDA) PD model. Oxidopamine 111-128 tyrosine hydroxylase Rattus norvegicus 28-30 24297323-0 2014 Ceftriaxone increases glutamate uptake and reduces striatal tyrosine hydroxylase loss in 6-OHDA Parkinson"s model. Oxidopamine 89-95 tyrosine hydroxylase Rattus norvegicus 60-80 24297323-4 2014 In association with >80% TH loss, we observed a significant decrease in glutamate uptake in the established 6-hydroxydopamine (6-OHDA) PD model. Oxidopamine 130-136 tyrosine hydroxylase Rattus norvegicus 28-30 24297323-6 2014 increased striatal glutamate uptake with >5 consecutive days of injection in nonlesioned rats and lasted out to 14 days postinjection, a time beyond that required for 6-OHDA to produce >70% TH loss (~9 days). Oxidopamine 170-176 tyrosine hydroxylase Rattus norvegicus 196-198 23714698-9 2013 Furthermore, catechin treatment restored GSH levels, and significantly increased dopamine and DOPAC content, and TH-immunoreactivity in 6-OHDA-lesioned rats. Oxidopamine 136-142 tyrosine hydroxylase Rattus norvegicus 113-115 24462728-5 2014 In addition, we found the tyrosine hydroxylase (TH) positive cells in the substantia nigra pars compacta (SNpc) did not increase after HFS-STN, while the expression of TH in the substantia nigra increased significantly compared to the 6-OHDA lesioned group. Oxidopamine 235-241 tyrosine hydroxylase Rattus norvegicus 168-170 23652161-5 2013 The significant loss of TH+ neurones by 6-OHDA administration was ameliorated by three different doses of DBZIM treatment in a bell-shape manner. Oxidopamine 40-46 tyrosine hydroxylase Rattus norvegicus 24-26 23868341-0 2013 Dynamic expressions of Beclin 1 and tyrosine hydroxylase in different areas of 6-hydroxydopamine-induced Parkinsonian rats. Oxidopamine 79-96 tyrosine hydroxylase Rattus norvegicus 36-56 23868341-3 2013 Therefore, we investigated dynamic expressions of Beclin 1 and tyrosine hydroxylase (TH) in different brain areas of 6-OHDA-induced rats. Oxidopamine 117-123 tyrosine hydroxylase Rattus norvegicus 63-83 23868341-3 2013 Therefore, we investigated dynamic expressions of Beclin 1 and tyrosine hydroxylase (TH) in different brain areas of 6-OHDA-induced rats. Oxidopamine 117-123 tyrosine hydroxylase Rattus norvegicus 85-87 23539311-3 2013 Treatments with either concentration of berberine (5 and 15 mg/kg) in 6-OHDA-lesioned groups decreased the numbers of tyrosine hydroxylase (TH)-immunopositive neurons in the substantia nigra and the levels of dopamine, norepinephrine, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the striatum as compared to 6-OHDA-lesioned groups. Oxidopamine 70-76 tyrosine hydroxylase Rattus norvegicus 118-138 23539311-5 2013 However, both concentrations of berberine in 6-OHDA-lesioned groups treated with L-DOPA aggravated the numbers of TH-immunopositive neurons in the substantia nigra and the levels of dopamine, norepinephrine, DOPAC and HVA in the striatum as compared to rats not treated with berberine. Oxidopamine 45-51 tyrosine hydroxylase Rattus norvegicus 114-116 23539311-3 2013 Treatments with either concentration of berberine (5 and 15 mg/kg) in 6-OHDA-lesioned groups decreased the numbers of tyrosine hydroxylase (TH)-immunopositive neurons in the substantia nigra and the levels of dopamine, norepinephrine, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the striatum as compared to 6-OHDA-lesioned groups. Oxidopamine 70-76 tyrosine hydroxylase Rattus norvegicus 140-142 23279934-5 2013 Dopamine transporters (DAT) and tyrosine hydroxylase (TH) were examined in 6-hydroxydopamine-treated PC12 after simvastatin treatment. Oxidopamine 75-92 tyrosine hydroxylase Rattus norvegicus 32-52 23279934-5 2013 Dopamine transporters (DAT) and tyrosine hydroxylase (TH) were examined in 6-hydroxydopamine-treated PC12 after simvastatin treatment. Oxidopamine 75-92 tyrosine hydroxylase Rattus norvegicus 54-56 23279934-7 2013 The downregulated DAT and TH levels in 6-OHDA-lesioned PC12 were restored after simvastatin treatment. Oxidopamine 39-45 tyrosine hydroxylase Rattus norvegicus 26-28 22850559-10 2012 These findings demonstrate that combined use of TH and AgNOR staining provides improved characterization of 6-OHDA-induced pathology. Oxidopamine 108-114 tyrosine hydroxylase Rattus norvegicus 48-50 23018122-7 2013 Animals in the 6-OHDA condition showed a mean reduction in TH staining of 88.27%. Oxidopamine 15-21 tyrosine hydroxylase Rattus norvegicus 59-61 18706980-2 2008 In the present study, double in situ hybridization was used to examine tyrosine hydroxylase (TH) and VGLUT2 mRNA expression during the embryonic development of these neurons, and postnatally, in normal rats and rats injected with 6-hydroxydopamine (6-OHDA) at P4 to destroy partially DA neurons. Oxidopamine 230-247 tyrosine hydroxylase Rattus norvegicus 71-91 22842585-7 2012 Furthermore, COX-2 expression in the rostral striatum showed a significant increase at 6h post-lesion while that of the caudal striatum was increased at 12 h. In the 6-OHDA-lesioned model, the activation of PPARgamma by rosiglitazone significantly prevented TH protein expression reductions, and inhibited 6-OHDA-induced microglia activation in striatum. Oxidopamine 166-172 tyrosine hydroxylase Rattus norvegicus 258-260 19844994-6 2009 Similarly, 17% of all TH terminals in normal neostriatum and 46% in the dopamine neoinnervation of SN in 6-OHDA-lesioned rats were also immunoreactive for VGLUT2 at P15, but none at P90. Oxidopamine 105-111 tyrosine hydroxylase Rattus norvegicus 22-24 18816795-0 2009 1,25-Dihydroxyvitamin D3 administration to 6-hydroxydopamine-lesioned rats increases glial cell line-derived neurotrophic factor and partially restores tyrosine hydroxylase expression in substantia nigra and striatum. Oxidopamine 43-60 tyrosine hydroxylase Rattus norvegicus 152-172 18816795-2 2009 This study was carried out to explore the effects of 1,25(OH)(2)D(3) administration in a 6-OHDA-lesioned rat model of Parkinson"s disease on GDNF and tyrosine hydroxylase (TH) expression in substantia nigra (SN) and striatum. Oxidopamine 89-95 tyrosine hydroxylase Rattus norvegicus 150-170 18816795-2 2009 This study was carried out to explore the effects of 1,25(OH)(2)D(3) administration in a 6-OHDA-lesioned rat model of Parkinson"s disease on GDNF and tyrosine hydroxylase (TH) expression in substantia nigra (SN) and striatum. Oxidopamine 89-95 tyrosine hydroxylase Rattus norvegicus 172-174 18816795-8 2009 As expected, 6-OHDA injection induced an ipsilateral decrease in TH-immunopositive neuronal cell bodies and axonal terminals in the SN and striatum. Oxidopamine 13-19 tyrosine hydroxylase Rattus norvegicus 65-67 18816795-9 2009 However, treatment with 1,25(OH)(2)D(3) before and after 6-OHDA injection partially restored TH expression in SN. Oxidopamine 57-63 tyrosine hydroxylase Rattus norvegicus 93-95 22622825-8 2012 RESULTS: The dopamine content in the striatum and the number of TH-immunoreactive neurons decreased after 6-OHDA treatment. Oxidopamine 106-112 tyrosine hydroxylase Rattus norvegicus 64-66 22048886-4 2012 The extent of the dopaminergic lesion induced by 6-OHDA was evaluated by apomorphine-induced rotational behavior and by tyrosine hydroxylase (TH) immunoreactivity. Oxidopamine 49-55 tyrosine hydroxylase Rattus norvegicus 120-140 20570658-1 2010 The aim of this study is to determine the efficacy of injecting adult bone marrow derived stem cells (BMSCs) transfected with a pEGFP-C2 plasmid containing the gene for Tyrosine Hydroxylase (TH) into the lateral ventricle for treating rats with Parkinson"s Disease (PD) induced by injections into the Substantia Nigra pars compacta (SNc) with 6-hydroxydopamine (6-OHDA), a potent and selective neurotoxin for catecholamine expressing neurons. Oxidopamine 343-360 tyrosine hydroxylase Rattus norvegicus 169-189 20570658-1 2010 The aim of this study is to determine the efficacy of injecting adult bone marrow derived stem cells (BMSCs) transfected with a pEGFP-C2 plasmid containing the gene for Tyrosine Hydroxylase (TH) into the lateral ventricle for treating rats with Parkinson"s Disease (PD) induced by injections into the Substantia Nigra pars compacta (SNc) with 6-hydroxydopamine (6-OHDA), a potent and selective neurotoxin for catecholamine expressing neurons. Oxidopamine 362-368 tyrosine hydroxylase Rattus norvegicus 169-189 18706980-8 2008 In 6-OHDA-lesioned rats, the total number of TH positive terminals was considerably reduced, and yet the proportion also displaying VGLUT2 immunoreactivity was modestly but significantly increased (37%). Oxidopamine 3-9 tyrosine hydroxylase Rattus norvegicus 45-47 18042492-5 2008 A current study also suggests that the co-expression of tyrosine hydroxylase (TH) and VGluT2 by these neurons is regulated during embryonic development, and may be derepressed or reactivated postnatally following their partial destruction by neonatal administration of 6-hydroxydopamine (6-OHDA). Oxidopamine 269-286 tyrosine hydroxylase Rattus norvegicus 56-76 18042492-5 2008 A current study also suggests that the co-expression of tyrosine hydroxylase (TH) and VGluT2 by these neurons is regulated during embryonic development, and may be derepressed or reactivated postnatally following their partial destruction by neonatal administration of 6-hydroxydopamine (6-OHDA). Oxidopamine 269-286 tyrosine hydroxylase Rattus norvegicus 78-80 18042492-5 2008 A current study also suggests that the co-expression of tyrosine hydroxylase (TH) and VGluT2 by these neurons is regulated during embryonic development, and may be derepressed or reactivated postnatally following their partial destruction by neonatal administration of 6-hydroxydopamine (6-OHDA). Oxidopamine 288-294 tyrosine hydroxylase Rattus norvegicus 56-76 18042492-5 2008 A current study also suggests that the co-expression of tyrosine hydroxylase (TH) and VGluT2 by these neurons is regulated during embryonic development, and may be derepressed or reactivated postnatally following their partial destruction by neonatal administration of 6-hydroxydopamine (6-OHDA). Oxidopamine 288-294 tyrosine hydroxylase Rattus norvegicus 78-80 18420351-6 2008 Immunofluorescence, reverse transcription (RT)-real time polymerase chain reaction (PCR) and Western blot were used to evaluate and compare the levels of mRNA and protein expression of tyrosine hydroxylase (TH) and dopamine transporter (DAT) in the GI tract between normal and rodent PD models, as well as between 6-OHDA-treated rats and MPTP-treated mice. Oxidopamine 314-320 tyrosine hydroxylase Rattus norvegicus 185-205 18420351-9 2008 The protein levels of TH and DAT in the GI tract were significantly increased in 6-OHDA-treated rats, but the protein level of TH was significantly decreased in MPTP-treated mice. Oxidopamine 81-87 tyrosine hydroxylase Rattus norvegicus 22-24 18430361-9 2008 Bilobalide inhibited the 6-OHDA-induced loss of TH-positive neurons, decreased the activation of NF-kappaB, and protected dopaminergic neurons from apoptosis remarkably. Oxidopamine 25-31 tyrosine hydroxylase Rattus norvegicus 48-50 17914186-7 2007 Tyrosine hydroxylase (TH) and dopamine transporter (DAT) immunohistochemistry (IHC) showed markedly decreased staining in ipsilateral SN and striatum in 6-OHDA but not AdLC or AdGFP rats. Oxidopamine 153-159 tyrosine hydroxylase Rattus norvegicus 0-20 15246853-0 2004 Quantitative analyses of GFRalpha-1 and GFRalpha-2 mRNAs and tyrosine hydroxylase protein in the nigrostriatal system reveal bilateral compensatory changes following unilateral 6-OHDA lesions in the rat. Oxidopamine 177-183 tyrosine hydroxylase Rattus norvegicus 61-81 16298737-4 2005 Unilateral infusion of 6-OHDA into the medial forebrain bundle produced a significant loss of tyrosine hydroxylase (TH)-positive cells in the substantia nigra (SN) as well as a decreased of dopamine (DA) content in the striata in the vehicle-treated animals. Oxidopamine 23-29 tyrosine hydroxylase Rattus norvegicus 116-118 15717064-8 2005 In the 6-hydroxydopamine rat model of experimental PD, striatal tyrosine hydroxylase (TH) activity is completely normalized after an intravenous administration of TfRmAb-targeted PILs carrying a TH expression plasmid. Oxidopamine 7-24 tyrosine hydroxylase Rattus norvegicus 64-84 15717064-8 2005 In the 6-hydroxydopamine rat model of experimental PD, striatal tyrosine hydroxylase (TH) activity is completely normalized after an intravenous administration of TfRmAb-targeted PILs carrying a TH expression plasmid. Oxidopamine 7-24 tyrosine hydroxylase Rattus norvegicus 86-88 15717064-8 2005 In the 6-hydroxydopamine rat model of experimental PD, striatal tyrosine hydroxylase (TH) activity is completely normalized after an intravenous administration of TfRmAb-targeted PILs carrying a TH expression plasmid. Oxidopamine 7-24 tyrosine hydroxylase Rattus norvegicus 195-197 15053859-4 2004 Striatal TH activity was 98% depleted with the unilateral intracerebral injection of 6-hydroxydopamine. Oxidopamine 85-102 tyrosine hydroxylase Rattus norvegicus 9-11 15142343-6 2004 In the vehicle-treated rats, infusion of 8 microg of 6-OHDA significantly reduced the number of TH+ cells in the SNpc as well as the levels of dopamine, DOPAC and HVA in the striata on the lesion side. Oxidopamine 53-59 tyrosine hydroxylase Rattus norvegicus 96-98 14696016-1 2004 A unilateral lesion of the rat nigrostriatal pathway with 6-hydroxydopamine (6-OHDA) results in a decrease in the basal extracellular level of striatal glutamate, a nearly complete loss of tyrosine hydroxylase (TH) immunolabeling, an increase in the density of glutamate immunogold labeling within nerve terminals making an asymmetrical synaptic contact, and an increase in the number of apomorphine-induced contralateral rotations. Oxidopamine 58-75 tyrosine hydroxylase Rattus norvegicus 189-209 14696016-1 2004 A unilateral lesion of the rat nigrostriatal pathway with 6-hydroxydopamine (6-OHDA) results in a decrease in the basal extracellular level of striatal glutamate, a nearly complete loss of tyrosine hydroxylase (TH) immunolabeling, an increase in the density of glutamate immunogold labeling within nerve terminals making an asymmetrical synaptic contact, and an increase in the number of apomorphine-induced contralateral rotations. Oxidopamine 58-75 tyrosine hydroxylase Rattus norvegicus 211-213 14696016-1 2004 A unilateral lesion of the rat nigrostriatal pathway with 6-hydroxydopamine (6-OHDA) results in a decrease in the basal extracellular level of striatal glutamate, a nearly complete loss of tyrosine hydroxylase (TH) immunolabeling, an increase in the density of glutamate immunogold labeling within nerve terminals making an asymmetrical synaptic contact, and an increase in the number of apomorphine-induced contralateral rotations. Oxidopamine 77-83 tyrosine hydroxylase Rattus norvegicus 189-209 14696016-1 2004 A unilateral lesion of the rat nigrostriatal pathway with 6-hydroxydopamine (6-OHDA) results in a decrease in the basal extracellular level of striatal glutamate, a nearly complete loss of tyrosine hydroxylase (TH) immunolabeling, an increase in the density of glutamate immunogold labeling within nerve terminals making an asymmetrical synaptic contact, and an increase in the number of apomorphine-induced contralateral rotations. Oxidopamine 77-83 tyrosine hydroxylase Rattus norvegicus 211-213 12165403-11 2002 The number of TH positive (TH+) neurons in the SNpc was 60% lower in 6-OHDA lesioned rats. Oxidopamine 69-75 tyrosine hydroxylase Rattus norvegicus 14-16 14673496-7 2003 When implanting RGLT-TH cells into the striatum of 6-hydroxydopamine (6-OHDA) lesioned hemiparkinsonism model rats, TH immunohistochemical staining showed the TH presence in striatum and HPLC-ECD analysis held at 6 months after cell implantation showed an increase of DA content in striatum. Oxidopamine 51-68 tyrosine hydroxylase Rattus norvegicus 21-23 14673496-7 2003 When implanting RGLT-TH cells into the striatum of 6-hydroxydopamine (6-OHDA) lesioned hemiparkinsonism model rats, TH immunohistochemical staining showed the TH presence in striatum and HPLC-ECD analysis held at 6 months after cell implantation showed an increase of DA content in striatum. Oxidopamine 70-76 tyrosine hydroxylase Rattus norvegicus 21-23 14673496-7 2003 When implanting RGLT-TH cells into the striatum of 6-hydroxydopamine (6-OHDA) lesioned hemiparkinsonism model rats, TH immunohistochemical staining showed the TH presence in striatum and HPLC-ECD analysis held at 6 months after cell implantation showed an increase of DA content in striatum. Oxidopamine 70-76 tyrosine hydroxylase Rattus norvegicus 116-118 14673496-7 2003 When implanting RGLT-TH cells into the striatum of 6-hydroxydopamine (6-OHDA) lesioned hemiparkinsonism model rats, TH immunohistochemical staining showed the TH presence in striatum and HPLC-ECD analysis held at 6 months after cell implantation showed an increase of DA content in striatum. Oxidopamine 70-76 tyrosine hydroxylase Rattus norvegicus 116-118 12965246-1 2003 The immunostaining for tyrosine hydroxylase (TH) in the substantia nigra pars compacta (SNpc) and in the ventral tegmental area (VTA) after intranigral infusion of 6-hydroxydopamine (6-OHDA, 6 microg/side) was analyzed in ovariectomized adult female Wistar rats. Oxidopamine 164-181 tyrosine hydroxylase Rattus norvegicus 23-43 12965246-1 2003 The immunostaining for tyrosine hydroxylase (TH) in the substantia nigra pars compacta (SNpc) and in the ventral tegmental area (VTA) after intranigral infusion of 6-hydroxydopamine (6-OHDA, 6 microg/side) was analyzed in ovariectomized adult female Wistar rats. Oxidopamine 164-181 tyrosine hydroxylase Rattus norvegicus 45-47 14689453-7 2004 Tyrosine hydroxylase (TH) immunocytochemistry confirmed that rats injected with 6-OHDA had a massive loss of TH immunoreactivity in both the ipsilateral substantia nigra compacta (60% loss) and the striatum (>95% loss) compared to the contralateral side. Oxidopamine 80-86 tyrosine hydroxylase Rattus norvegicus 0-20 14689453-7 2004 Tyrosine hydroxylase (TH) immunocytochemistry confirmed that rats injected with 6-OHDA had a massive loss of TH immunoreactivity in both the ipsilateral substantia nigra compacta (60% loss) and the striatum (>95% loss) compared to the contralateral side. Oxidopamine 80-86 tyrosine hydroxylase Rattus norvegicus 22-24 14689453-7 2004 Tyrosine hydroxylase (TH) immunocytochemistry confirmed that rats injected with 6-OHDA had a massive loss of TH immunoreactivity in both the ipsilateral substantia nigra compacta (60% loss) and the striatum (>95% loss) compared to the contralateral side. Oxidopamine 80-86 tyrosine hydroxylase Rattus norvegicus 109-111 12691607-1 2003 We previously reported long-term biochemical and behavioral correction of the 6-hydroxydopamine (6-OHDA) rat model of Parkinson"s disease (PD) by expression of tyrosine hydroxylase (TH) in the partially denervated striatum, using a herpes simplex virus type 1 (HSV-1) vector. Oxidopamine 78-95 tyrosine hydroxylase Rattus norvegicus 160-180 12691607-1 2003 We previously reported long-term biochemical and behavioral correction of the 6-hydroxydopamine (6-OHDA) rat model of Parkinson"s disease (PD) by expression of tyrosine hydroxylase (TH) in the partially denervated striatum, using a herpes simplex virus type 1 (HSV-1) vector. Oxidopamine 78-95 tyrosine hydroxylase Rattus norvegicus 182-184 12691607-1 2003 We previously reported long-term biochemical and behavioral correction of the 6-hydroxydopamine (6-OHDA) rat model of Parkinson"s disease (PD) by expression of tyrosine hydroxylase (TH) in the partially denervated striatum, using a herpes simplex virus type 1 (HSV-1) vector. Oxidopamine 97-103 tyrosine hydroxylase Rattus norvegicus 160-180 12691607-1 2003 We previously reported long-term biochemical and behavioral correction of the 6-hydroxydopamine (6-OHDA) rat model of Parkinson"s disease (PD) by expression of tyrosine hydroxylase (TH) in the partially denervated striatum, using a herpes simplex virus type 1 (HSV-1) vector. Oxidopamine 97-103 tyrosine hydroxylase Rattus norvegicus 182-184 12691607-4 2003 Coexpression of TH and AADC supported high-level (80%), behavioral correction of the 6-OHDA rat model of PD for 5 weeks. Oxidopamine 85-91 tyrosine hydroxylase Rattus norvegicus 16-18 12165403-11 2002 The number of TH positive (TH+) neurons in the SNpc was 60% lower in 6-OHDA lesioned rats. Oxidopamine 69-75 tyrosine hydroxylase Rattus norvegicus 27-29 12176170-6 2002 Tyrosine hydroxylase (TH)-immunoreactive neurons of the substantia nigra were protected from progressive degeneration in the neurturin-treated animals compared with the vehicle-treated animals 2 and 8 weeks after the 6-OHDA lesion. Oxidopamine 217-223 tyrosine hydroxylase Rattus norvegicus 0-20 11241387-5 2001 Sprague-Dawley rats receiving unilateral intrastriatal 6-OHDA injections (4 x 5 microg) exhibited a 30-70% reduction in striatal TH-positive fiber density along an anterior-posterior gradient, an 80% loss of nigral dopamine neurons and a mild degree of behavioral impairments as revealed by amphetamine-induced rotational asymmetry, and a reduced performance in the stepping and postural balance tests. Oxidopamine 55-61 tyrosine hydroxylase Rattus norvegicus 129-131 11983283-1 2002 Differentiation of neural stem cells into tyrosine hydroxylase (TH)-expressing cells was studied by cell transplantation into the various brain regions of rats that had received 6-hydroxydopamine lesion of the nigrostriatal pathway. Oxidopamine 178-195 tyrosine hydroxylase Rattus norvegicus 64-66 12658754-5 2002 The present study demonstrates that intrastriatal heterograft of glomus cells within carotid body in rats with 6-OHDA-elicited lesions could reduce apomorphine-induced rotational behavior and elevate the dopamine contents and numbers of TH+ cell surviving within striatum, and can serve as a new and effective alternative for Parkinson disease. Oxidopamine 111-117 tyrosine hydroxylase Rattus norvegicus 237-239 10719076-6 2000 Following 6-OHDA injection, the number of TH immunopositive neurons in the ipsilateral SNc was reduced. Oxidopamine 10-16 tyrosine hydroxylase Rattus norvegicus 42-44 10945765-3 2000 We previously showed that the coexpression of tyrosine hydroxylase (TH) and aromatic-L-amino-acid decarboxylase (AADC), using two separate adeno-associated virus (AAV) vectors, resulted in more effective dopamine production and more remarkable behavioral recovery in 6-hydroxydopamine-lesioned parkinsonian rats, compared with the expression of TH alone. Oxidopamine 267-284 tyrosine hydroxylase Rattus norvegicus 68-70 10865059-0 2000 On the altered expression of tyrosine hydroxylase and calbindin-D 28kD immunoreactivities and viability of neurons in the ventral tegmental area of Tsai following injections of 6-hydroxydopamine in the medial forebrain bundle in the rat. Oxidopamine 177-194 tyrosine hydroxylase Rattus norvegicus 29-49 9973233-2 1999 Chemical sympathectomy with 6-hydroxydopamine (6-OHDA) markedly decreased norepinephrine and to a generally lesser extent TH activities and dopamine in most peripheral tissues (stomach, lung, testis, duodenum, pancreas, salivary gland, spleen, heart, kidney, thymus). Oxidopamine 28-45 tyrosine hydroxylase Rattus norvegicus 122-124 10694827-2 2000 Implanting TH gene-transfected myoblasts into the denervated striatum of 6-OHDA-lesioned rats significantly decreased rotational asymmetry by 50 to approximately 60%. Oxidopamine 73-79 tyrosine hydroxylase Rattus norvegicus 11-13 10529440-5 1999 Histological analysis revealed a significant reduction in the number of cell bodies immunostained for tyrosine hydroxylase (TH+) within the transplant for those animals pretreated with an intrastriatal injection of citrate buffer and subsequently given either dose of 6-OHDA. Oxidopamine 268-274 tyrosine hydroxylase Rattus norvegicus 102-122 10564366-4 1999 In the present study we establish that after unilateral 6-hydroxydopamine lesions or methamphetamine administration, striatal TH-immunoreactive neurons differ in size, morphology and location from those that are immunopositive for AADC or dopamine. Oxidopamine 56-73 tyrosine hydroxylase Rattus norvegicus 126-128 10366015-8 1999 There was a decrease of tyrosine hydroxylase- and transferrin receptor-positive cells in the 6-hydroxydopamine-lesioned substantia nigra. Oxidopamine 93-110 tyrosine hydroxylase Rattus norvegicus 24-44 9973233-2 1999 Chemical sympathectomy with 6-hydroxydopamine (6-OHDA) markedly decreased norepinephrine and to a generally lesser extent TH activities and dopamine in most peripheral tissues (stomach, lung, testis, duodenum, pancreas, salivary gland, spleen, heart, kidney, thymus). Oxidopamine 47-53 tyrosine hydroxylase Rattus norvegicus 122-124 9973233-5 1999 Stomach also showed consistent expression of TH mRNA before, but not after 6-OHDA, suggesting that catecholamine synthesizing cells in gastric tissue are sensitive to the toxic effects of 6-OHDA. Oxidopamine 188-194 tyrosine hydroxylase Rattus norvegicus 45-47 9853519-0 1998 Behavioral recovery in 6-hydroxydopamine-lesioned rats by cotransduction of striatum with tyrosine hydroxylase and aromatic L-amino acid decarboxylase genes using two separate adeno-associated virus vectors. Oxidopamine 23-40 tyrosine hydroxylase Rattus norvegicus 90-110 9171157-0 1997 Differential dissection of the rat E16 ventral mesencephalon and survival and reinnervation of the 6-OHDA-lesioned striatum by a subset of aldehyde dehydrogenase-positive TH neurons. Oxidopamine 99-105 tyrosine hydroxylase Rattus norvegicus 171-173 9270064-0 1997 Cyclosporin A attenuates the decrease in tyrosine hydroxylase immunoreactivity in nigrostriatal dopaminergic neurons and in striatal dopamine content in rats with intrastriatal injection of 6-hydroxydopamine. Oxidopamine 190-207 tyrosine hydroxylase Rattus norvegicus 41-61 9270064-3 1997 Tyrosine hydroxylase immunoreactivity (TH-IR) of the cell bodies in the substantia nigra pars compacta (SNc) ipsilateral to the injection were lower than on the contralateral side at 4 weeks but not at 1 week after 6-OHDA injection. Oxidopamine 215-221 tyrosine hydroxylase Rattus norvegicus 0-20 8635567-6 1996 Transplantation of the TH-transduced astrocytes to the striatum in unilaterally 6-hydroxydopamine lesioned rats reduced apomorphine-induced turning by about 50% at 2 weeks postgrafting. Oxidopamine 80-97 tyrosine hydroxylase Rattus norvegicus 23-25 7599533-1 1995 Levels of catecholamines and the synthesizing enzyme, tyrosine hydroxylase (TH) are markedly decreased in the dorsal striatum, caudate-putamen nuclei, following neurotoxic lesions with 6-hydroxy-dopamine (6-OHDA). Oxidopamine 185-203 tyrosine hydroxylase Rattus norvegicus 54-74 8847744-3 1995 Neonatal 6-OHDA injection causes norepinephrine (NE) depletion in the frontal cortex, which triggers a compensatory increase of dopamine, serotonin (5-HT), and met-enkephalin content correlated by the increased density of tyrosine hydroxylase- and 5-HT-positive axons. Oxidopamine 9-15 tyrosine hydroxylase Rattus norvegicus 222-242 7599533-1 1995 Levels of catecholamines and the synthesizing enzyme, tyrosine hydroxylase (TH) are markedly decreased in the dorsal striatum, caudate-putamen nuclei, following neurotoxic lesions with 6-hydroxy-dopamine (6-OHDA). Oxidopamine 185-203 tyrosine hydroxylase Rattus norvegicus 76-78 7599533-1 1995 Levels of catecholamines and the synthesizing enzyme, tyrosine hydroxylase (TH) are markedly decreased in the dorsal striatum, caudate-putamen nuclei, following neurotoxic lesions with 6-hydroxy-dopamine (6-OHDA). Oxidopamine 205-211 tyrosine hydroxylase Rattus norvegicus 54-74 7599533-1 1995 Levels of catecholamines and the synthesizing enzyme, tyrosine hydroxylase (TH) are markedly decreased in the dorsal striatum, caudate-putamen nuclei, following neurotoxic lesions with 6-hydroxy-dopamine (6-OHDA). Oxidopamine 205-211 tyrosine hydroxylase Rattus norvegicus 76-78 7599533-3 1995 The peroxidase-antiperoxidase (PAP) method was used to localize rabbit antiserum against TH in caudate-putamen nuclei of adult rats given unilateral nigral injections of either vehicle or 6-hydroxydopamine in the early postnatal period. Oxidopamine 188-205 tyrosine hydroxylase Rattus norvegicus 89-91 7599533-8 1995 Ipsilateral to the 6-OHDA injections, the density (numbers/area) of striatal TH-immunoreactive terminals was reduced by 50-90% in the majority of animals. Oxidopamine 19-25 tyrosine hydroxylase Rattus norvegicus 77-79 1349737-2 1992 Following neonatal 6-hydroxydopamine treatment, the proportion of tyrosine hydroxylase-immunoreactive and neuropeptide Y-immunoreactive neurons in ciliary ganglia was significantly increased. Oxidopamine 19-36 tyrosine hydroxylase Rattus norvegicus 66-86 8097862-0 1993 Quantitation of the levels of tyrosine hydroxylase and preproenkephalin mRNAs in nigrostriatal sites after 6-hydroxydopamine lesions. Oxidopamine 107-124 tyrosine hydroxylase Rattus norvegicus 30-50 8097862-4 1993 Four weeks after 6-OHDA treatment, TH mRNA levels were reduced below the limits of sensitivity of the assay (1 pg/ug RNA) in ipsilateral SN while the levels of TH mRNA in contralateral SN (4.8 pg/ug RNA) did not differ from that in sham treated animals. Oxidopamine 17-23 tyrosine hydroxylase Rattus norvegicus 35-37 8097862-4 1993 Four weeks after 6-OHDA treatment, TH mRNA levels were reduced below the limits of sensitivity of the assay (1 pg/ug RNA) in ipsilateral SN while the levels of TH mRNA in contralateral SN (4.8 pg/ug RNA) did not differ from that in sham treated animals. Oxidopamine 17-23 tyrosine hydroxylase Rattus norvegicus 160-162 1345939-8 1992 6-Hydroxydopamine, shown previously to increase levels of TH and firing rate of LC neurons, also increased soluble levels of protein kinase activity. Oxidopamine 0-17 tyrosine hydroxylase Rattus norvegicus 58-60 1356749-0 1992 Tetrahydrobiopterin-dependent functional recovery in 6-hydroxydopamine-treated rats by intracerebral grafting of fibroblasts transfected with tyrosine hydroxylase cDNA. Oxidopamine 53-70 tyrosine hydroxylase Rattus norvegicus 142-162 8096162-1 1993 We studied the effects of neonatal intracisternal administration of the 6-hydroxydopamine (6-OHDA) following desipramine pretreatment on dopaminergic (DA) neurons in the rat hypothalamus and substantia nigra by immunocytochemistry with an antiserum against tyrosine hydroxylase (TH). Oxidopamine 72-89 tyrosine hydroxylase Rattus norvegicus 257-277 1279138-6 1992 The 6-OHDA lesions that eliminated nearly all TH-like immunostaining in the host striatum also resulted in disappearance of nearly all TH-positive fibers in the grafts. Oxidopamine 4-10 tyrosine hydroxylase Rattus norvegicus 46-48 1279138-6 1992 The 6-OHDA lesions that eliminated nearly all TH-like immunostaining in the host striatum also resulted in disappearance of nearly all TH-positive fibers in the grafts. Oxidopamine 4-10 tyrosine hydroxylase Rattus norvegicus 135-137 1349737-6 1992 Like tyrosine hydroxylase immunoreactivity, the number of ciliary neurons containing tyrosine hydroxylase mRNA and the amount of mRNA per cell were increased in 6-hydroxydopamine-treated rats. Oxidopamine 161-178 tyrosine hydroxylase Rattus norvegicus 5-25 1349737-6 1992 Like tyrosine hydroxylase immunoreactivity, the number of ciliary neurons containing tyrosine hydroxylase mRNA and the amount of mRNA per cell were increased in 6-hydroxydopamine-treated rats. Oxidopamine 161-178 tyrosine hydroxylase Rattus norvegicus 85-105 6198035-6 1983 Axonal transport of D beta H and TH was assessed by measuring the accumulation of enzyme activity proximal to a 6-OHDA lesion made in the more caudal portion of these same LC axons. Oxidopamine 112-118 tyrosine hydroxylase Rattus norvegicus 33-35 1907216-4 1991 Tyrosine hydroxylase (TH) was used as a specific marker of DA fibers after lesioning the noradrenergic system either with 6-hydroxydopamine (6-OHDA) at birth or DSP4 in adulthood. Oxidopamine 122-139 tyrosine hydroxylase Rattus norvegicus 0-20 34512945-10 2021 Our results for the first time showed that, besides improving the motor performance, CAPE treatment also prevents 6-OHDA-induced loss of TH-positive neurons. Oxidopamine 114-120 tyrosine hydroxylase Rattus norvegicus 137-139 2427735-9 1986 In addition, the relative abundance of adrenomedullary TH mRNA increased by 60% 4 days after systemic administration of the neurotoxin 6-hydroxydopamine. Oxidopamine 135-152 tyrosine hydroxylase Rattus norvegicus 55-57 2864660-3 1985 Tyrosine hydroxylase was used as an immunocytochemical marker after destruction of the cortical noradrenergic system, induced either neonatally by 6-hydroxydopamine or later on by DSP4, and controlled by the absence of dopamine beta-hydroxylase immunoreactivity. Oxidopamine 147-164 tyrosine hydroxylase Rattus norvegicus 0-20 2858582-5 1985 However, adrenal TH is activated by acute cold exposure if the sympathetic nerves, that normally are stimulated during cold, are destroyed previously by 6-hydroxydopamine treatment. Oxidopamine 153-170 tyrosine hydroxylase Rattus norvegicus 17-19 6101509-0 1980 Compensatory increase in tyrosine hydroxylase activity in rat brain after intraventricular injections of 6-hydroxydopamine. Oxidopamine 105-122 tyrosine hydroxylase Rattus norvegicus 25-45 6125573-13 1981 These short and long term alterations in tyrosine hydroxylase activity after 6-hydroxydopamine treatment may represent adaptive responses to the lesion. Oxidopamine 77-94 tyrosine hydroxylase Rattus norvegicus 41-61 87244-4 1979 6-Hydroxydopamine variably blocked transport of all 4 waves of 3H protein and bilateral injections decreased hypothalamic levels of TH, DBH and NE by 58.2, 56.9 and 52.2% of controls, respectively. Oxidopamine 0-17 tyrosine hydroxylase Rattus norvegicus 132-134 28554-0 1978 Tyrosine hydroxylase activity in brain regions after intraventricular 6-hydroxydopamine in the neonatal rat. Oxidopamine 70-87 tyrosine hydroxylase Rattus norvegicus 0-20 28554-1 1978 Intraventricular 6-OHDA treatment to newborn rats produced a marked reduction in tyrosine hydroxylase activity in most brain regions at maturity which correlated moderately well with the catecholamine levels. Oxidopamine 17-23 tyrosine hydroxylase Rattus norvegicus 81-101 32441169-6 2021 The immunoreactivities for tyrosine hydroxylase (TH) was determined using immunohistochemistry.Results: In the RAM test, the 6-OHDA-induced increases in the reference and working memory errors were reduced by the central NPS administration. Oxidopamine 125-131 tyrosine hydroxylase Rattus norvegicus 27-47