PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18338798-5 2008 Impaired fos mRNA responses to nicotine administration in the celiac ganglia of 6-OHDA-pretreated rats correlated temporally with suppressed expression of functional nicotinic receptors. Oxidopamine 80-86 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 9-12 18338798-8 2008 The principal neurons in rat celiac ganglia were reflexively activated by 2-deoxy-glucose-induced glucopenia, and the Fos response in the celiac ganglia was markedly inhibited by pretreatment with 6-OHDA. Oxidopamine 197-203 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 118-121 16706847-6 2006 The objective of this work was to study the effects of acute or chronic systemic administration of L-DOPA to adult rats with a unilateral 6-hydroxydopamine (6-OHDA) lesion of dopamine neurons on c-fos expression in the STN and test the hypothesis that these effects correlate with L-DOPA-induced dyskinesias. Oxidopamine 138-155 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 195-200 17006656-0 2006 Fos immunoreactivity in some locomotor neural centres of 6OHDA-lesioned rats. Oxidopamine 57-62 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 0-3 17006656-7 2006 In conclusion, we reveal an increase in the number of strongly labelled Fos+ cells within the cuneiform nucleus of the so-called defensive locomotive system in 6OHDA-lesioned rats. Oxidopamine 160-165 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 72-75 16725125-0 2006 Repeated l-DOPA treatment increases c-fos and BDNF mRNAs in the subthalamic nucleus in the 6-OHDA rat model of Parkinson"s disease. Oxidopamine 91-97 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 36-41 17848208-1 2008 OBJECTIVE: In an effort to understand cell activity patterns and sensorimotor integration in Parkinson"s disease, we have explored the expression of the Fos protein in the subthalamus after sensory (nociceptive) stimulation of hemiparkinsonian Sprague-Dawley rats [6-hydroxydopamine [6OHDA]-lesioned]. Oxidopamine 265-282 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 153-156 17848208-1 2008 OBJECTIVE: In an effort to understand cell activity patterns and sensorimotor integration in Parkinson"s disease, we have explored the expression of the Fos protein in the subthalamus after sensory (nociceptive) stimulation of hemiparkinsonian Sprague-Dawley rats [6-hydroxydopamine [6OHDA]-lesioned]. Oxidopamine 284-289 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 153-156 17848208-7 2008 However, in the cases that had 6OHDA-lesions combined with mechanical stimulation, there were many Fos+ cells within the subthalamus of both sides, particularly on the ipsilateral side. Oxidopamine 31-36 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 99-102 16504219-5 2006 In rats treated with 6-hydroxydopamine (6-OHDA) to lesion the nigrostriatal dopamine (DA) pathway, DOPA significantly induced c-Fos expression in the four regions under the inhibition of peripheral AADC. Oxidopamine 21-38 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 126-131 16504219-5 2006 In rats treated with 6-hydroxydopamine (6-OHDA) to lesion the nigrostriatal dopamine (DA) pathway, DOPA significantly induced c-Fos expression in the four regions under the inhibition of peripheral AADC. Oxidopamine 40-46 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 126-131 16706847-6 2006 The objective of this work was to study the effects of acute or chronic systemic administration of L-DOPA to adult rats with a unilateral 6-hydroxydopamine (6-OHDA) lesion of dopamine neurons on c-fos expression in the STN and test the hypothesis that these effects correlate with L-DOPA-induced dyskinesias. Oxidopamine 157-163 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 195-200 16706847-8 2006 Our results confirm earlier evidence that the chronic administration of L-DOPA to rats with a unilateral 6-OHDA lesion increases c-fos expression in the STN. Oxidopamine 105-111 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 129-134 16706847-9 2006 We also report that c-fos expression can be increased following an acute injection of L-DOPA to 6-OHDA-lesioned rats but not following a chronic injection of L-DOPA to sham-operated, unlesioned rats. Oxidopamine 96-102 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 20-25 11282380-1 2001 Three priming injections with the D1/D2 dopamine agonist apomorphine permits a challenge with the D2 agonist quinpirole to elicit robust contralateral rotation and ipsilateral striatal Fos expression in 6-hydroxydopamine lesioned rats. Oxidopamine 203-220 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 185-188 15713275-7 2005 Animals previously given 6-hydroxydopamine (6-OHDA) injections into the ascending DA pathways had greater total numbers of cortical stimulation-induced striatal Fos-ir cells but fewer Fos-ir/PV-ir cells, compared to sham-operates. Oxidopamine 25-42 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 161-164 15713275-7 2005 Animals previously given 6-hydroxydopamine (6-OHDA) injections into the ascending DA pathways had greater total numbers of cortical stimulation-induced striatal Fos-ir cells but fewer Fos-ir/PV-ir cells, compared to sham-operates. Oxidopamine 25-42 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 184-187 15713275-7 2005 Animals previously given 6-hydroxydopamine (6-OHDA) injections into the ascending DA pathways had greater total numbers of cortical stimulation-induced striatal Fos-ir cells but fewer Fos-ir/PV-ir cells, compared to sham-operates. Oxidopamine 44-50 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 161-164 15713275-7 2005 Animals previously given 6-hydroxydopamine (6-OHDA) injections into the ascending DA pathways had greater total numbers of cortical stimulation-induced striatal Fos-ir cells but fewer Fos-ir/PV-ir cells, compared to sham-operates. Oxidopamine 44-50 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 184-187 12184738-6 2002 Furthermore, dopaminergic denervation by 6-hydroxydopamine did not inhibit but rather potentiated the 7-OH-DPAT-induced c-fos mRNA expression in the cerebellum. Oxidopamine 41-58 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 120-125 15016420-3 2004 Central sympathectomy with intracerebroventricular injection of 6-OHDA significantly reduced the elevation of the plasma corticosterone level, the expression of Fos in hypothalamic paraventricular nucleus and in locus coeruleus, as well as the suppression of NK activity induced by cold stress at 4 degrees C for 4 h. Peripheral sympathectomy with intraperitoneal (i.p.) Oxidopamine 64-70 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 161-164 15036599-4 2004 injection of 6-OHDA reduced significantly the elevation of plasma corticosterone level, the expression of Fos in hypothalamic paraventricular nucleus and in locus coeruleus, as well as the suppression of NK activity induced by cold stress at 4 degrees C for 4 h. Peripheral sympathectomy with intraperitoneal (i.p.) Oxidopamine 13-19 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 106-109 12213641-1 2002 The expression of early response gene proteins c-Fos, c-Jun, and GAP-43 and their association with 6-hydroxydopamine (6-OHDA)-mediated oxidative injury were investigated using catecholaminergic PC12 cell line. Oxidopamine 118-124 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 47-52 12213641-2 2002 Significant induction in the expression of c-Fos (P < 0.01), c-Jun (P < 0.001) and GAP-43 (P < 0.05) was observed following 2 h exposure to 6-OHDA (10(-6) M), which persisted during 24 h of observation. Oxidopamine 140-146 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 43-48 11011010-7 2000 Furthermore, L-DOPA produced a dramatic induction of c-Fos in the CPu in 6-OHDA-lesioned animals. Oxidopamine 73-79 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 53-58 11070194-0 2000 Effects of repeated methyl levodopa administration on apomorphine sensitivity of rotational behavior and striatal Fos expression of rats with unilateral 6-OHDA lesions. Oxidopamine 153-159 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 114-117 11501038-11 2000 CONCLUSION: In the 6-OHDA-lesioned rats, the rotation induced by SPD was kept on a high activity, which was in pace with the inducement of Fos expression and the reduction of expression of PENK mRNA in the denervated striatum. Oxidopamine 19-25 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 139-142 10408602-5 1999 Apomorphine and quinpirole increased the discharge rate and induced a strong expression of c-Fos-like immunoreactive proteins, whereas SKF 82958 induced a decrease of the discharge rate and a slight expression of c-Fos in 6-hydroxydopamine-lesioned rats. Oxidopamine 222-239 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 213-218 10819899-5 2000 Moreover, intranigral DNQX elicited more turning and greater numbers of Fos-positive striatal neurons in 6-OHDA-lesioned animals than in unlesioned controls, suggesting that the 6-OHDA injection induces functional changes in nigral glutamate transmission. Oxidopamine 105-111 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 72-75 10819899-5 2000 Moreover, intranigral DNQX elicited more turning and greater numbers of Fos-positive striatal neurons in 6-OHDA-lesioned animals than in unlesioned controls, suggesting that the 6-OHDA injection induces functional changes in nigral glutamate transmission. Oxidopamine 178-184 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 72-75 10819899-11 2000 6-OHDA-lesioned rats given 5 microg of intrastriatal quinpirole exhibited both turning and pallidal Fos that was significantly increased by intranigral AP5. Oxidopamine 0-6 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 100-103 10579212-0 1999 Prior D1 dopamine receptor stimulation is required to prime D2-mediated striatal Fos expression in 6-hydroxydopamine-lesioned rats. Oxidopamine 99-116 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 81-84 10683409-4 2000 Following 6-hydroxydopamine infusions into the medial forebrain bundle in awake, behaving rats, there was a rapid and transient induction of striatal c-fos and zif/268 messenger RNAs. Oxidopamine 10-27 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 150-155 10683409-7 2000 6-Hydroxydopamine-induced c-fos messenger RNA was also observed in the substantia nigra pars reticulata and entopeduncular nucleus, but not the globus pallidus, 45 min after medial forebrain bundle 6-hydroxydopamine infusions. Oxidopamine 0-17 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 26-31 10683409-7 2000 6-Hydroxydopamine-induced c-fos messenger RNA was also observed in the substantia nigra pars reticulata and entopeduncular nucleus, but not the globus pallidus, 45 min after medial forebrain bundle 6-hydroxydopamine infusions. Oxidopamine 198-215 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 26-31 10320705-0 1999 Time dependence and role of N-methyl-D-aspartate glutamate receptors in the priming of D2-mediated rotational behavior and striatal Fos expression in 6-hydroxydopamine lesioned rats. Oxidopamine 150-167 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 132-135 10320705-2 1999 Previously, we have shown that 6-OHDA rats primed with three injections of the D1/D2 dopamine agonist apomorphine (0.5 mg/kg) permitted a challenge with an otherwise inactive dose of the D2 agonist quinpirole (0.25 mg/kg) to elicit robust rotational behavior and to induce Fos expression in striatoentopeduncular neurons. Oxidopamine 31-37 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 273-276 9630593-0 1998 c-fos gene expression is induced in a subpopulation of striatal neurons following a single administration of a dopamine D1-receptor agonist in adult rats lesioned with 6-OHDA as neonates. Oxidopamine 168-174 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 0-5 9852594-7 1998 Furthermore, a unilateral 6-hydroxydopamine lesion of the mesostriatal dopamine system reduced amphetamine- but not novelty-induced c-fos expression. Oxidopamine 26-43 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 132-137 9759976-12 1998 Additionally, examination of FOS-like immunoreactivity revealed a distinct pattern following L-(+)-2-amino-4-phosphonobutyrate administration in 6-hydroxydopamine lesioned versus intact rats. Oxidopamine 145-162 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 29-32 9795171-9 1998 It is suggested that the FLIs in the two discrete sites are activated independently by different mechanisms, and furthermore, different neuronal pathways are involved in the methamphetamine-induced rotation and Fos expression in the SNr of 6-OHDA rats. Oxidopamine 240-246 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 211-214 9178866-12 1997 Thus, the quinpirole-dependent induction of striatal Fos in apomorphine-primed 6-hydroxydopamine-lesioned rats represents a qualitative alteration in striatal outflow. Oxidopamine 79-96 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 53-56 9678640-0 1998 Methamphetamine-induced Fos expression in the substantia nigra pars reticulata in rats with a unilateral 6-OHDA lesion of the nigrostriatal fibers. Oxidopamine 105-111 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 24-27 9262200-5 1997 Thirty-six hours after 6-hydroxydopamine lesion, a considerable reduction in treadmill-induced Fos expression was observed in both sides; however, Fos expression in the lesioned striatum was higher than in the contralateral intact striatum. Oxidopamine 23-40 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 95-98 9262200-6 1997 Several weeks after unilateral 6-hydroxydopamine lesion of the nigrostriatal system, treadmill-induced Fos expression was significantly, but not totally, reduced in the lesioned striatum. Oxidopamine 31-48 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 103-106 9195609-7 1997 Studies on c-fos expression induced by DA D1 agonists in the 6-OHDA lesioned striatum show that detection of Fos-like immunoreactivity correlates to the long-term but not the acute effects induced by DA receptor stimulation and NMDA receptor blockade. Oxidopamine 61-67 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 11-16 9195609-7 1997 Studies on c-fos expression induced by DA D1 agonists in the 6-OHDA lesioned striatum show that detection of Fos-like immunoreactivity correlates to the long-term but not the acute effects induced by DA receptor stimulation and NMDA receptor blockade. Oxidopamine 61-67 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 109-112 9219861-6 1997 Lesions of the dopaminergic mesostriatal projection by 6-hydroxydopamine and stimulation of dopamine D2/D3 receptors by quinpirole, prevented CGS 21680-induced Fos-like immunoreactivity in the nucleus accumbens shell. Oxidopamine 55-72 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 160-163 8883820-1 1996 In rats with a unilateral 6-hydroxydopamine lesion of the ascending dopamine neurons, we investigated the relationship between the expression of Fos-like immunoreactivity in the caudate-putamen and contralateral turning behavior in response to dopamine agonists during the induction and expression of sensitization (priming) to D1-dependent turning behavior. Oxidopamine 26-43 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 145-148 9063681-0 1997 Adenosine A2A receptor antagonism potentiates L-DOPA-induced turning behaviour and c-fos expression in 6-hydroxydopamine-lesioned rats. Oxidopamine 103-120 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 83-88 9063681-5 1997 Expression of c-fos as measured by Fos-like immunoreactivity after SCH 58261 plus L-DOPA was also potentiated as compared with L-DOPA alone, both in striatum and globus pallidus of the 6-hydroxydopamine-lesioned side of the brain. Oxidopamine 185-202 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 14-19 9017239-0 1996 Synergistic interaction between an adenosine antagonist and a D1 dopamine agonist on rotational behavior and striatal c-Fos induction in 6-hydroxydopamine-lesioned rats. Oxidopamine 137-154 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 118-123 9017239-4 1996 However, the regional pattern of striatal c-Fos activation following treatment of 6-OHDA rats with SKF38393 and DMPX was different from the dorsolateral pattern of striatal c-Fos induction observed after coadministration of D1 and D2 dopamine agonists (SKF38393: 0.5 mg/kg + quinpirole: 0.05 mg/kg). Oxidopamine 82-88 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 42-47 8813576-4 1996 markedly increased the striatal c-fos mRNA levels (about eight-fold at 30 mg/kg), the increase being abolished by lesioning of dopamine neurons with 6-hydroxydopamine. Oxidopamine 149-166 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 32-37 8752587-2 1996 SCH 58261 also increased the number of Fos-like positive nuclei induced by SKF 38393 in the 6-hydroxydopamine-lesioned striatum. Oxidopamine 92-109 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 39-42 7477908-0 1995 Adenosine A2 receptors stimulate c-fos expression in striatal neurons of 6-hydroxydopamine-lesioned rats. Oxidopamine 73-90 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 33-38 8714707-1 1996 Using an antibody that recognizes the products of all known members of the fos family of immediate early genes, it was demonstrated that destruction of the nigrostriatal pathway by 6-hydroxydopamine (6-OHDA) lesions of the medial forebrain bundle produces a prolonged (>3 months) elevation of Fos-like immunoreactivity in the striatum. Oxidopamine 181-198 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 75-78 8714707-1 1996 Using an antibody that recognizes the products of all known members of the fos family of immediate early genes, it was demonstrated that destruction of the nigrostriatal pathway by 6-hydroxydopamine (6-OHDA) lesions of the medial forebrain bundle produces a prolonged (>3 months) elevation of Fos-like immunoreactivity in the striatum. Oxidopamine 181-198 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 296-299 8714707-1 1996 Using an antibody that recognizes the products of all known members of the fos family of immediate early genes, it was demonstrated that destruction of the nigrostriatal pathway by 6-hydroxydopamine (6-OHDA) lesions of the medial forebrain bundle produces a prolonged (>3 months) elevation of Fos-like immunoreactivity in the striatum. Oxidopamine 200-206 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 75-78 8714707-1 1996 Using an antibody that recognizes the products of all known members of the fos family of immediate early genes, it was demonstrated that destruction of the nigrostriatal pathway by 6-hydroxydopamine (6-OHDA) lesions of the medial forebrain bundle produces a prolonged (>3 months) elevation of Fos-like immunoreactivity in the striatum. Oxidopamine 200-206 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 296-299 8714707-3 1996 In the present study, Western blots were performed on nuclear extracts from the intact and denervated striatum of 6-OHDA-lesioned rats to determine the nature of Fos-immunoreactive protein(s) responsible for this increase. Oxidopamine 114-120 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 162-165 8714707-4 1996 Approximately 6 weeks after the 6-OHDA lesion, expression of two Fos-related antigens with apparent molecular masses of 43 and 45 kDa was enhanced in the denervated striatum. Oxidopamine 32-38 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 65-68 8721156-0 1996 Time course of striatal changes induced by 6-hydroxydopamine lesion of the nigrostriatal pathway, as studied by combined evaluation of rotational behaviour and striatal Fos expression. Oxidopamine 43-60 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 169-172 8741770-0 1995 Intrastriatal DNQX induces rotation and pallidal Fos in the 6-OHDA model of Parkinson"s disease. Oxidopamine 60-66 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 49-52 7478217-0 1995 Elevated striatal Fos immunoreactivity following 6-hydroxydopamine lesioning of the rat is mediated by excitatory amino acid transmission. Oxidopamine 49-66 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 18-21 7478217-5 1995 The results demonstrate that dopamine depletion following 6-hydroxydopamine lesioning can result in elevated striatal Fos levels which can be attenuated by contiguous treatment with an NMDA antagonist. Oxidopamine 58-75 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 118-121 7477908-2 1995 CGS 21680 (2.25 mg/kg) induces c-fos expression in the 6-hydroxydopamine-lesioned striatum, while up to 40 mg/kg fails to induce c-fos in the intact striatum or in the striatum of normal rats. Oxidopamine 55-72 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 31-36 7477908-3 1995 Blockade of muscarine receptors by scopolamine (5 mg/kg) partially prevents, and stimulation of dopamine D2 receptors by quinpirole (0.5 mg/kg) completely reverses, CGS 21680-induced c-fos expression in the 6-hydroxydopamine-lesioned striatum. Oxidopamine 207-224 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 183-188 7477877-6 1995 It was demonstrated that in drug-naive rats bearing unilateral 6-hydroxydopamine lesions of the dopaminergic nigrostriatal pathway, the mixed D1/D2 agonist apomorphine produced a dramatic increase in the expression of Fos-like immunoreactivity in the ipsilateral caudoputamen, nucleus accumbens and globus pallidus, and was a potent primer of SKF-38393-mediated rotational behaviour. Oxidopamine 63-80 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 218-221 7538563-9 1995 Amphetamine-induced striatal Fos expression was normalized in the caudate-putamen ipsilateral to the intranigral VM grafts, showing hyperexpression in some areas of the striatum, and the apomorphine-induced Fos expression seen in the 6-OHDA-lesioned animals was completely reversed on the grafted side. Oxidopamine 234-240 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 29-32 7792718-2 1995 Local infusion into the SN of the 6-OHDA lesioned side of MK 801, CPP or NBQX at doses inducing no or minimal behavioral effects significantly increased the turning behavior and the expression of c-fos induced, in the lesioned caudate-putamen (CPu), by a parenteral administration of SKF 38393. Oxidopamine 34-40 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 196-201 8527000-6 1995 In the striata of 6-OHDA-lesioned rats, PENK gene is upregulated, PDYN gene is down-regulated and the induction of c-fos gene by D2 receptor antagonists is abolished, whereas selective D1 receptor agonists induce c-fos gene, which does not occur in non-lesioned rats. Oxidopamine 18-24 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 115-120 8748612-2 1995 Local infusion into the SN of the 6-OHDA lesioned side of NMDA glutamate antagonists MK 801 and CPP or the AMPA antagonist NBQX at doses inducing none or minimal behavioral effects, significantly increased the turning behavior and the expression of c-fos induced, in the lesioned caudate-putamen (CPu), by a parenteral administration of SKF 38393. Oxidopamine 34-40 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 249-254 8527000-6 1995 In the striata of 6-OHDA-lesioned rats, PENK gene is upregulated, PDYN gene is down-regulated and the induction of c-fos gene by D2 receptor antagonists is abolished, whereas selective D1 receptor agonists induce c-fos gene, which does not occur in non-lesioned rats. Oxidopamine 18-24 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 213-218 7886620-0 1994 Differential effect of MK 801 and scopolamine on c-fos expression induced by L-dopa in the striatum of 6-hydroxydopamine lesioned rats. Oxidopamine 103-120 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 49-54 7886620-1 1994 In rats with a unilateral 6-hydroxydopamine lesion of the dopaminergic nigro-striatal pathway, striatal D1-receptor-stimulated c-fos expression and turning behavior are positively modulated by D2 receptor stimulation and by blockade of N-methyl-D-aspartate (NMDA) or muscarinic receptors. Oxidopamine 26-43 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 127-132 7937819-5 1994 Because expression of the c-fos gene in response to cAMP- and Ca2+/calmodulin-regulated protein kinases depends on phosphorylation of cAMP-response element-binding protein (CREB) at Ser-133, we examined CREB phosphorylation after dopaminergic stimulation in cultured striatal neurons and in the striatum of rats after unilateral 6-hydroxydopamine ablation of the substantia nigra. Oxidopamine 329-346 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 26-31 8221117-1 1993 Administration of L-dopa to unilaterally 6-hydroxydopamine-lesioned rats, activates the early gene c-fos in the lesioned caudate-putamen. Oxidopamine 41-58 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 99-104 7914658-0 1994 Role of a 35 kDa fos-related antigen (FRA) in the long-term induction of striatal dynorphin expression in the 6-hydroxydopamine lesioned rat. Oxidopamine 110-127 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 17-20 7914658-11 1994 Consistent with the notion that Fos and FRA proteins alter transcriptional activity by binding to AP-1 (or AP-1-like) DNA sequences in the promoter regions of target genes, we found that repeated APO treatment caused large increases in AP-1 binding activity in striata ipsilateral to 6-OHDA lesions. Oxidopamine 284-290 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 32-35 7908600-1 1993 Fos expression in the globus pallidus (GP) of rats was elicited by the D2 agonist quinpirole both ipsilateral and contralateral to a unilateral nigrostriatal 6-hydroxydopamine (6-OHDA) injection; however, the 6-OHDA-treated hemisphere was more sensitive to this effect. Oxidopamine 158-175 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 0-3 7908600-1 1993 Fos expression in the globus pallidus (GP) of rats was elicited by the D2 agonist quinpirole both ipsilateral and contralateral to a unilateral nigrostriatal 6-hydroxydopamine (6-OHDA) injection; however, the 6-OHDA-treated hemisphere was more sensitive to this effect. Oxidopamine 177-183 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 0-3 7908600-1 1993 Fos expression in the globus pallidus (GP) of rats was elicited by the D2 agonist quinpirole both ipsilateral and contralateral to a unilateral nigrostriatal 6-hydroxydopamine (6-OHDA) injection; however, the 6-OHDA-treated hemisphere was more sensitive to this effect. Oxidopamine 209-215 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 0-3 1361576-7 1992 These findings demonstrate that regionally enhanced electrophysiological sensitivity of striatal neurons to D1-DA receptor agonists after neonatal 6-OHDA-induced lesions is associated with regional changes in c-fos-like immunoreactivity and tyrosine hydroxylase-like immunohistochemistry, but not with changes in D1-DA receptor autoradiography or D1-DA-stimulated adenylyl cyclase activity. Oxidopamine 147-153 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 209-214 8098138-0 1993 Blockade of muscarinic receptors potentiates D1 dependent turning behavior and c-fos expression in 6-hydroxydopamine-lesioned rats but does not influence D2 mediated responses. Oxidopamine 99-116 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 79-84 8098512-4 1993 We have examined the expression of immediate early genes in central neurons of the rat and now show that a 6-hydroxydopamine-induced axotomy of the dopaminergic nigrostriatal pathway results in a substantial increase in the levels of c-jun (but not c-fos) messenger RNA and protein within neurons of the substantia nigra pars compacta. Oxidopamine 107-124 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 249-254 25637312-5 2015 Rats with 6-OHDA lesions showed increased face rubbings in the second phase when formalin was injected ipsilaterally to the lesion, and c-Fos expression in the Vc increased. Oxidopamine 10-16 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 136-141 1360906-5 1992 This stimulatory effect of amphetamine on c-fos expression was blocked by 6-hydroxydopamine hydrobromide lesions and was restored in the striata bearing transplants. Oxidopamine 74-104 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 42-47 1347413-0 1992 Dopaminergic transplants normalize amphetamine- and apomorphine-induced Fos expression in the 6-hydroxydopamine-lesioned striatum. Oxidopamine 94-111 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 72-75 1681407-0 1991 Prolonged and selective induction of Fos-related antigen(s) in striatal neurons after 6-hydroxydopamine lesions of the rat substantia nigra pars compacta. Oxidopamine 86-103 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 37-40 1681407-1 1991 Unilateral 6-hydroxydopamine (6-OHDA) lesions of the rat substantia nigra lead to a large widespread and long-lasting (greater than 3 months) increased expression of Fos-related antigen(s) (FRAs) in striatal neurons ipsilateral to the side of the lesion. Oxidopamine 11-28 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 166-169 1681407-1 1991 Unilateral 6-hydroxydopamine (6-OHDA) lesions of the rat substantia nigra lead to a large widespread and long-lasting (greater than 3 months) increased expression of Fos-related antigen(s) (FRAs) in striatal neurons ipsilateral to the side of the lesion. Oxidopamine 30-36 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 166-169 1357113-4 1992 In rats with unilateral 6-hydroxydopamine (6-OHDA) lesions of the nigrostriatal pathway, D1-selective (but not D2-selective) dopamine agonists produce a marked increase in expression of the immediate-early gene c-fos in the striatum ipsilateral to the 6-OHDA lesion. Oxidopamine 24-41 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 211-216 1357113-4 1992 In rats with unilateral 6-hydroxydopamine (6-OHDA) lesions of the nigrostriatal pathway, D1-selective (but not D2-selective) dopamine agonists produce a marked increase in expression of the immediate-early gene c-fos in the striatum ipsilateral to the 6-OHDA lesion. Oxidopamine 43-49 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 211-216 31704349-0 2020 c-Fos Expression after Stochastic Vestibular Stimulation and Levodopa in 6-OHDA Hemilesioned Rats. Oxidopamine 73-79 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 0-5 31704349-6 2020 Furthermore, c-Fos expression increased more in the habenula nucleus (LHb) after SVS than it did after levodopa in 6-OHDA hemilesioned animals and after saline in the sham-lesioned animals. Oxidopamine 115-121 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 13-18 31805115-7 2019 Significant increase of c-Fos-IR cells in the Vc was found in 6-OHDA-injected rats after formalin administration compared with those in saline-injected rats after formalin administration. Oxidopamine 62-68 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 24-29 31805115-8 2019 We also assessed expression of c-Fos-IR cells in the paraventricular nucleus (PVN), and significant decrease of c-Fos-IR cells in the PVN of 6-OHDA-injected rats was found. Oxidopamine 141-147 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 31-36 31805115-8 2019 We also assessed expression of c-Fos-IR cells in the paraventricular nucleus (PVN), and significant decrease of c-Fos-IR cells in the PVN of 6-OHDA-injected rats was found. Oxidopamine 141-147 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 112-117 30772369-7 2019 Striatal 6-OHDA induced motor impairments and reduced dopaminergic neuron immunolabeling as well as the pattern of neuronal activation (c-Fos) in the substantia nigra ipsilateral (IPL) to the lesion. Oxidopamine 9-15 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 136-141 25327342-10 2014 HM01 increased Fos-ir cell number in the area postrema, arcuate nucleus, nucleus tractus solitarius, and lumbosacral intermediolateral column of 6-OHDA rats where 6-OHDA had a lowering effect compared to controls. Oxidopamine 163-169 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 15-18 19800912-0 2010 D1 priming enhances both D1- and D2-mediated rotational behavior and striatal Fos expression in 6-hydroxydopamine lesioned rats. Oxidopamine 96-113 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 78-81 21855627-0 2011 c-Fos expression after deep brain stimulation of the pedunculopontine tegmental nucleus in the rat 6-hydroxydopamine Parkinson model. Oxidopamine 99-116 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 0-5 20677375-9 2010 Adolescent rats with 6-OHDA lesions subjected to restraint stress had greater c-fos expression in the AcbC, AcbSh, DG, Ce, BL, and Tc, compared to the sham and control groups, whereas these differences were not observed among the adult groups. Oxidopamine 21-27 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 78-83 20677375-0 2010 Age-specific effects of 6-hydroxydopamine lesions of the rat medial prefrontal cortex on stress-induced c-fos expression in subcortical areas. Oxidopamine 24-41 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 105-110 20677375-2 2010 Therefore, we investigated the effects of 6-OHDA lesions of the mPFC in adolescent and adult rats on stress-induced c-fos expression in the brain. Oxidopamine 42-48 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 116-121 19800912-5 2010 6-OHDA rats challenged with SKF38393 (1mg/kg) showed no contralateral rotational behavior, but robust striatal Fos expression in D1-primed animals. Oxidopamine 0-6 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 111-114 19800912-8 2010 These data suggest that D1- or D2-priming enhances rotational behavior following challenge with D1 or D2 agonist, but only D1-priming enhances D1- and D2-mediated striatal Fos expression in 6-OHDA rats. Oxidopamine 190-196 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 172-175 18576208-0 2008 Patterns of FOS expression in the spinal cord and periaqueductal grey matter of 6OHDA-lesioned rats. Oxidopamine 80-85 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 12-15 18663473-3 2008 Fos-ir was assessed after intra-pallidal injections of the excitatory amino acid agonist, NMDA, or the GABA(A) antagonist, bicuculline in normal rats and in those rendered Parkinsonian-like by lesioning dopaminergic neurons with the neurotoxin, 6-OHDA. Oxidopamine 245-251 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 0-3 18792992-1 2008 The goal of this study was to examine the topological specificity of methamphetamine-induced activation of the immediate-early gene proteins, Fos and Zif268, in the nigrostriatal system in a unilateral 6-hydroxydopamine (6-OHDA) rat model of Parkinson"s disease with or without intrastriatal grafts of fetal ventral mesencephalon. Oxidopamine 202-219 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 142-145 18792992-1 2008 The goal of this study was to examine the topological specificity of methamphetamine-induced activation of the immediate-early gene proteins, Fos and Zif268, in the nigrostriatal system in a unilateral 6-hydroxydopamine (6-OHDA) rat model of Parkinson"s disease with or without intrastriatal grafts of fetal ventral mesencephalon. Oxidopamine 221-227 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 142-145 18792992-3 2008 induced Fos-like immunoreactivity (FLI) dominantly in the striatum and the globus pallidus (GP) on the intact side as well as in the substantia nigra pars reticulata (SNr) on the lesioned side in the 6-OHDA rats. Oxidopamine 200-206 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 8-11 18792992-8 2008 The differential expression of Fos and Zif268 was observed among the three regions of the nigrostriatal system following methamphetamine in the 6-OHDA rats. Oxidopamine 144-150 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 31-34 18576208-7 2008 In the PaG, there were many more Fos(+) cells in the 6OHDA-lesioned than in the Control group, in both the stimulation and, in particular, the non-stimulation cases. Oxidopamine 53-58 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 33-36 18576208-8 2008 In the spinal cord, there were also more Fos(+) cells in the 6OHDA-lesioned than in the Control group, but in the stimulation cases only. Oxidopamine 61-66 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 41-44 18576208-9 2008 Overall, the results show distinct changes in Fos expression in the spinal cord and PaG of 6OHDA-lesioned rats, suggesting a substrate for some of the abnormal sensory (nociceptive) circuits that may be evident in parkinsonian cases. Oxidopamine 91-96 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 46-49