PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33652071-8 2021 These findings indicate that CYP3A5, CYP3A4, CYP2C8 and CYP2C9 play a major role in the transformation of carfentanil to M1 (norcarfentanil), M11, M13 and M15 through N-dealkylation of piperidine ring, hydroxylation of phenethyl group and ketone formation on phenethyl linker by human liver micrsomes. Norcarfentanil 125-139 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 37-43