PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26453165-1	2015	BACKGROUND: Phosphatidylinositol-3,4,5-trisphosphate (PIP3) is a major lipid second messenger in insulin-mediated signalling towards the metabolic actions of this hormone in muscle and fat.	PIP3	54-58	insulin	Homo sapiens	97-104	
26683831-4	2016	We found that the insulin secretagogue glucose promotes phosphatidylinositol (3,4,5)-trisphosphate (PIP3) generation through phosphoinositide 3-kinase (PI3K), thereby recruiting ARNO to the intracellular side of the plasma membrane.	PIP3	100-104	insulin	Homo sapiens	18-25	
26453165-2	2015	PURPOSE: Assessing the intracellular transport of exogenous PIP3 attached to a polymeric carrier in an attempt to overcome cellular insulin resistance.	PIP3	60-64	insulin	Homo sapiens	132-139	
26453165-7	2015	CONCLUSIONS: Inducing insulin actions by intracellular PIP3 delivery (PEI-25/PIP3 complexes) in some forms of insulin-resistant cells provides the first proof-of-principle for the potential therapeutic use of PIP3 in a "second-messenger agonist" approach.	PIP3	55-59	insulin	Homo sapiens	22-29	
26453165-7	2015	CONCLUSIONS: Inducing insulin actions by intracellular PIP3 delivery (PEI-25/PIP3 complexes) in some forms of insulin-resistant cells provides the first proof-of-principle for the potential therapeutic use of PIP3 in a "second-messenger agonist" approach.	PIP3	55-59	insulin	Homo sapiens	110-117	
22880106-6	2012	These data suggest that in the presence of insulin, the dissociated Synip remains anchored to the plasma membrane by binding to PIP3.	PIP3	128-132	insulin	Homo sapiens	43-50	
24647478-7	2014	This BRET biosensor pair permits to monitor, in real time, in living cells, PIP3 production at the plasma membrane upon stimulation by different ligands, including insulin, the insulin analogue glargine, IGF1, IGF2 and EGF.	PIP3	76-80	insulin	Homo sapiens	164-171	
24647478-7	2014	This BRET biosensor pair permits to monitor, in real time, in living cells, PIP3 production at the plasma membrane upon stimulation by different ligands, including insulin, the insulin analogue glargine, IGF1, IGF2 and EGF.	PIP3	76-80	insulin	Homo sapiens	177-184	
19854158-7	2009	Thus, phosphorylation of PHB and its interaction with PIP3 may be a part of the regulatory mechanisms that is involved in the modulation of insulin signaling.	PIP3	54-58	insulin	Homo sapiens	140-147	
16179727-5	2005	Interestingly, insulin-sensitizing agents (e.g., thiazolidinediones, metformin) improve aPKC activation by insulin in vivo and PIP3 in vitro, most likely by activating 5"-adenosine monophosphate-activated protein kinase, which favorably alters intracellular lipid metabolism.	PIP3	127-131	insulin	Homo sapiens	15-22	
16502970-1	2005	We have demonstrated that insulin stimulates sodium reabsorption in the distal nephron by stimulating the phosphatidylinositol 3-kinase (PI 3-kinase) pathway and that any stimulation of this enzyme (e.g. by EGF, by H2O2 or by exogenous PIP3, added apically) leads to a parallel increase in sodium reabsorption.	PIP3	236-240	insulin	Homo sapiens	26-33	
11270682-2	2001	By dephosphorylation of phosphatidyl-inositol-(3, 4, 5)-trisphosphate (PIP3) the PTEN protein regulates the insulin-dependent phosphoinositide 3-kinase (PI3K) signalling cassette and accordingly might function as a regulator of insulin sensitivity in skeletal muscle and adipose tissue.	PIP3	71-75	insulin	Homo sapiens	108-115	
11270682-2	2001	By dephosphorylation of phosphatidyl-inositol-(3, 4, 5)-trisphosphate (PIP3) the PTEN protein regulates the insulin-dependent phosphoinositide 3-kinase (PI3K) signalling cassette and accordingly might function as a regulator of insulin sensitivity in skeletal muscle and adipose tissue.	PIP3	71-75	insulin	Homo sapiens	228-235