PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16943182-5 2006 In DOCK2-deficient neutrophils, chemoattractant-induced activation of both Rac1 and Rac2 were severely impaired, resulting in the loss of polarized accumulation of F-actin and phosphatidylinositol 3,4,5-triphosphate (PIP3) at the leading edge. PIP3 217-221 dedicator of cytokinesis 2 Homo sapiens 3-8