PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29967243-5	2018	Rac1 also selectively interacts with phosphatidic acid (PA) and phosphoinositol (3,4,5)-trisphosphate (PIP3), resulting in nanoclusters enriched in these lipids.	PIP3	103-107	Rac family small GTPase 1	Homo sapiens	0-4	
29967243-6	2018	These lipids are structurally important because depleting the PM of PA or PIP3 impairs both Rac1 PM binding and Rac1 nanoclustering.	PIP3	74-78	Rac family small GTPase 1	Homo sapiens	92-96	
29967243-6	2018	These lipids are structurally important because depleting the PM of PA or PIP3 impairs both Rac1 PM binding and Rac1 nanoclustering.	PIP3	74-78	Rac family small GTPase 1	Homo sapiens	112-116	
29141223-5	2017	These nanoclusters assemble because of the interaction of the polybasic tail of Rac1 with the phosphoinositide lipids PIP2 and PIP3.	PIP3	127-131	Rac family small GTPase 1	Homo sapiens	80-84	
11805146-2	2002	Here we report that Vav3 influences phosphoinositide 3-kinase (PI3K) function through Rac1 in that phosphatidylinositol-3,4,5-trisphosphate (PIP3) generation was attenuated by loss of Vav3 or by expression of a dominant negative form of Rac1.	PIP3	141-145	Rac family small GTPase 1	Homo sapiens	86-90	
11805146-2	2002	Here we report that Vav3 influences phosphoinositide 3-kinase (PI3K) function through Rac1 in that phosphatidylinositol-3,4,5-trisphosphate (PIP3) generation was attenuated by loss of Vav3 or by expression of a dominant negative form of Rac1.	PIP3	141-145	Rac family small GTPase 1	Homo sapiens	237-241	
26438819-1	2015	Phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger 2 (PREX2) is a guanine nucleotide exchange factor (GEF) for the Ras-related C3 botulinum toxin substrate 1 (Rac1) GTPase, facilitating the exchange of GDP for GTP on Rac1.	PIP3	42-46	Rac family small GTPase 1	Homo sapiens	136-178	
26438819-1	2015	Phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger 2 (PREX2) is a guanine nucleotide exchange factor (GEF) for the Ras-related C3 botulinum toxin substrate 1 (Rac1) GTPase, facilitating the exchange of GDP for GTP on Rac1.	PIP3	42-46	Rac family small GTPase 1	Homo sapiens	180-184	
26438819-1	2015	Phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger 2 (PREX2) is a guanine nucleotide exchange factor (GEF) for the Ras-related C3 botulinum toxin substrate 1 (Rac1) GTPase, facilitating the exchange of GDP for GTP on Rac1.	PIP3	42-46	Rac family small GTPase 1	Homo sapiens	238-242	
26438819-6	2015	Following PREX2-mediated activation of Rac1 by the second messengers PIP3 or Gbetagamma, we found that PREX2 was phosphorylated through a PAK-dependent mechanism.	PIP3	69-73	Rac family small GTPase 1	Homo sapiens	39-43	
26438819-7	2015	PAK-mediated phosphorylation of PREX2 reduced GEF activity toward Rac1 by inhibiting PREX2 binding to PIP3 and Gbetagamma.	PIP3	102-106	Rac family small GTPase 1	Homo sapiens	66-70	
16943182-5	2006	In DOCK2-deficient neutrophils, chemoattractant-induced activation of both Rac1 and Rac2 were severely impaired, resulting in the loss of polarized accumulation of F-actin and phosphatidylinositol 3,4,5-triphosphate (PIP3) at the leading edge.	PIP3	217-221	Rac family small GTPase 1	Homo sapiens	75-79