PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14534366-4 2003 Dissociation of [3H][Dmt1]DALDA was also rapid (K(-1) = 0.032 min(-1)) and indicated binding to a single site. Tritium 17-19 doublesex and mab-3 related transcription factor 1 Homo sapiens 21-25 14534366-2 2003 In an attempt to better understand the unique pharmacological profile of [Dmt1]DALDA, we have prepared [3H][Dmt1]DALDA and compared its binding properties with that of [3H]DAMGO ([d-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin). Tritium 104-106 doublesex and mab-3 related transcription factor 1 Homo sapiens 108-112 14534366-5 2003 [3H][Dmt1]DALDA binds with very high affinity to human mu opioid receptor (hMOR) (Kd = 0.199 nM), and Kd and Bmax were reduced by sodium but not Gpp(NH)p [guanosine 5"-(beta,gamma-imido)triphosphate]. Tritium 1-3 doublesex and mab-3 related transcription factor 1 Homo sapiens 5-9 14534366-9 2003 The Ki values for a number of opioid ligands were generally higher when determined by competitive displacement binding against [3H][Dmt1]DALDA compared with [3H]DAMGO, with the exception of Dmt1-substituted peptide analogs. Tritium 128-130 doublesex and mab-3 related transcription factor 1 Homo sapiens 132-136 14534366-12 2003 The very high affinity and selectivity of [3H][Dmt1]DALDA for the mu receptor, together with its very low nonspecific binding (10-15%) and metabolic stability, make [3H][Dmt1]DALDA an ideal radioligand for labeling mu receptors. Tritium 43-45 doublesex and mab-3 related transcription factor 1 Homo sapiens 47-51 14534366-12 2003 The very high affinity and selectivity of [3H][Dmt1]DALDA for the mu receptor, together with its very low nonspecific binding (10-15%) and metabolic stability, make [3H][Dmt1]DALDA an ideal radioligand for labeling mu receptors. Tritium 43-45 doublesex and mab-3 related transcription factor 1 Homo sapiens 170-174 14534366-12 2003 The very high affinity and selectivity of [3H][Dmt1]DALDA for the mu receptor, together with its very low nonspecific binding (10-15%) and metabolic stability, make [3H][Dmt1]DALDA an ideal radioligand for labeling mu receptors. Tritium 166-168 doublesex and mab-3 related transcription factor 1 Homo sapiens 47-51 14534366-12 2003 The very high affinity and selectivity of [3H][Dmt1]DALDA for the mu receptor, together with its very low nonspecific binding (10-15%) and metabolic stability, make [3H][Dmt1]DALDA an ideal radioligand for labeling mu receptors. Tritium 166-168 doublesex and mab-3 related transcription factor 1 Homo sapiens 170-174