PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29864448-8 2018 alpha7-containing and beta2-containing nAChRs were involved in nicotine-induced [3H]-GABA release in control and mdx synaptosomes. Tritium 81-83 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 0-6 24953818-6 2014 Inhibition of nAChR-evoked [(3)H]-GABA release by (R)-baclofen was time sensitive and the effect was lost after prolonged exposure to the GABAB agonist. Tritium 28-32 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 14-19 22820264-4 2012 Daily intraperitoneal injection of alpha7 nAChR agonist PNU-282987 (3-10mg/kg) for 3 days, starting from 3h after induction of ICH, significantly increased the number of surviving neurons in the central and the peripheral regions of hematoma at 3 days after ICH. Tritium 105-107 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 35-47 20387628-6 2009 Anti-CD40-induced B lymphocyte proliferation studied by [3H]thymidine incorporation was increased upon alpha7 nAChR inhibition with methyllicaconitine, choline or antibiotic gentamicin, as well as in the presence of the inhibitor of acetylcholine synthesis hemicholine-3. Tritium 57-59 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 103-115 17631923-1 2007 [3H]Epibatidine binds to nAChR subtypes in mouse brain with higher (KD approximately 0.02 nM) and lower affinity (KD approximately 7 nM), which can be further subdivided through inhibition by selected agonists and antagonists. Tritium 1-3 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 25-30 17631923-4 2007 Deletion of the alpha7, beta2 or beta4 nicotinic receptor subunit genes identifies highly expressed subtypes with relatively low affinity for [3H]epibatidine. Tritium 143-145 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 16-22 17631923-9 2007 Deletion of alpha4 virtually eliminated cytisine-sensitive, higher-affinity [3H]epibatidine binding as did beta2 deletion, confirming that these sites are alpha4beta2*-nAChR. Tritium 77-79 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 168-173 16728647-15 2006 These studies establish that the lower-affinity sites represent a structurally diverse set of sites that require expression of either alpha7, beta2, or beta4 subunits and extend and confirm previous classifications of the higher-affinity [3H]epibatidine binding sites. Tritium 239-241 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 134-140 16216068-6 2005 [3H]APFBzcholine photolabeled gammaLeu-109/deltaLeu-111, gammaTyr-111, and gammaTyr-117 in binding site segment E as well as alphaTyr-198 in alpha subunit binding site segment C. The observed pattern of photolabeling is examined in relation to the predicted orientation of the azide when APFBzcholine is docked in the agonist binding site of a homology model of the nAChR extracellular domain based upon the structure of the snail acetylcholine binding protein. Tritium 1-3 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 366-371 10350488-1 1999 Photoaffinity labeling of the Torpedo nicotinic acetylcholine receptor (nAChR) with [3H]d-tubocurarine (dTC) has identified a residue within the gamma-subunit which, along with the analogous residue in delta-subunit, confers selectivity in binding affinities between the two agonist sites for dTC and alpha-conotoxin (alpha Ctx) MI. Tritium 85-87 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 38-70 10350488-1 1999 Photoaffinity labeling of the Torpedo nicotinic acetylcholine receptor (nAChR) with [3H]d-tubocurarine (dTC) has identified a residue within the gamma-subunit which, along with the analogous residue in delta-subunit, confers selectivity in binding affinities between the two agonist sites for dTC and alpha-conotoxin (alpha Ctx) MI. Tritium 85-87 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 72-77 10350488-2 1999 nAChR gamma-subunit, isolated from nAChR-rich membranes photolabeled with [3H]dTC, was digested with Staphylococcus aureus V8 protease, and a 3H-labeled fragment was purified by reversed-phase high-performance liquid chromatography. Tritium 75-77 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 0-5 10350488-2 1999 nAChR gamma-subunit, isolated from nAChR-rich membranes photolabeled with [3H]dTC, was digested with Staphylococcus aureus V8 protease, and a 3H-labeled fragment was purified by reversed-phase high-performance liquid chromatography. Tritium 142-144 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 0-5 9808692-11 1998 The pharmacological and regional comparisons suggest that the nAChR that stimulates [3H]-GABA release is the one that binds [3H]-nicotine with high affinity (alpha4beta2). Tritium 85-87 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 62-67 9808692-11 1998 The pharmacological and regional comparisons suggest that the nAChR that stimulates [3H]-GABA release is the one that binds [3H]-nicotine with high affinity (alpha4beta2). Tritium 125-127 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 62-67 8868061-1 1995 Three days of treatment with the glucocorticoid dexamethasone (1 nM-1 microM) induced a concentration-dependent up-regulation of muscle nicotinic acetylcholine receptor (nAChR) in C2C12 mouse myotubes (EC50 = 10 +/- 7.3 nM), as assessed by [3H]alpha-BuTx binding. Tritium 241-243 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 170-175 8196506-1 1994 [3H]Cytisine was evaluated as an in vivo ligand for the nicotinic cholinergic receptor (nAchR) in mouse brain. Tritium 1-3 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 88-93