PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30255549-4 2018 Mechanistically, PRPS1 mutants increase the level of intracellular phosphoribosyl pyrophosphate (PRPP), which causes the apt conversion of 5-FU to FUMP and FUTP in Reh cells, to promote 5-FU-induced DNA damage and apoptosis. FUMP 147-151 phosphoribosyl pyrophosphate synthetase 1 Homo sapiens 17-22