PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26202359-7	2015	Furthermore, Notch inhibitor DAPT induced early autophagy by acting on PTEN-PI3K/Akt/mTOR pathway.	dapt	29-33	AKT serine/threonine kinase 1	Homo sapiens	81-84	
34295560-0	2021	DAPT suppresses proliferation and migration of hepatocellular carcinoma by regulating the extracellular matrix and inhibiting the Hes1/PTEN/AKT/mTOR signaling pathway.	dapt	0-4	AKT serine/threonine kinase 1	Homo sapiens	140-143	
34295560-9	2021	DAPT significantly inhibited the proliferation and migration of HepG2 cells in a dose-dependent manner, accompanied by the suppression of Notch1/Hes1 signaling, inactivation of AKT/mTOR signaling, downregulation of MMPs, and decreased expression of adhesion molecules.	dapt	0-4	AKT serine/threonine kinase 1	Homo sapiens	177-180	
29956731-11	2018	Additionally, the combination of quercetin-3-methyl ether and a secretase inhibitor (DAPT) exhibited additive suppression of the expression of Notch1, PI3K, Akt and mammalian target of rapamycin and a more marked inhibitory effect on cell proliferation and colony formation compared with either drug alone.	dapt	85-89	AKT serine/threonine kinase 1	Homo sapiens	157-160	
27570480-10	2016	Finally, Ang II-activated ERK1/2, JNK and Akt were also counteracted by DAPT.	dapt	72-76	AKT serine/threonine kinase 1	Homo sapiens	42-45	
34295560-10	2021	The activation of Notch1/Hes1 or AKT/mTOR signaling removed the inhibitory effect of DAPT on the proliferation and migration of HepG2 cells, as well as the inhibitory properties of DAPT on the expression of MMPs and adhesion molecules.	dapt	85-89	AKT serine/threonine kinase 1	Homo sapiens	33-36	
34295560-10	2021	The activation of Notch1/Hes1 or AKT/mTOR signaling removed the inhibitory effect of DAPT on the proliferation and migration of HepG2 cells, as well as the inhibitory properties of DAPT on the expression of MMPs and adhesion molecules.	dapt	181-185	AKT serine/threonine kinase 1	Homo sapiens	33-36	
34295560-12	2021	Conclusions: DAPT could suppress the proliferation and migration of HCC by regulating the ECM and inhibiting the Hes1/PTEN/AKT/mTOR signaling pathway.	dapt	13-17	AKT serine/threonine kinase 1	Homo sapiens	123-126	
31057403-5	2019	Phosphorylation of AKT on S473 was surprisingly increased when Notch signaling was inhibited by DAPT.	dapt	96-100	AKT serine/threonine kinase 1	Homo sapiens	19-22	
31057403-6	2019	Inhibition of PI3K and AKT by LY294002 and MK2206, respectively, or knockdown of AKT expression by siRNA blocked DAPT-induced activation of Cdc42.	dapt	113-117	AKT serine/threonine kinase 1	Homo sapiens	81-84	
31057403-8	2019	Taken together, these results indicated that DAPT inhibited Notch signaling and consequently activated PI3K/AKT/Cdc42 signaling by non-canonical pathway, facilitated the formation of filopodia and inhibited the assembly of lamellipodia, and finally resulted in the decrease of migration activity of breast cancer cells.	dapt	45-49	AKT serine/threonine kinase 1	Homo sapiens	108-111	
29964327-7	2019	We also found that the combination of CDDP and DAPT exhibit additive suppression on phosphorylated AKT and ERK, contributing to the anti-cancer effects.	dapt	47-51	AKT serine/threonine kinase 1	Homo sapiens	99-102	
26716652-8	2016	Here we report that the combination of RY10-4 and DAPT exhibit additive suppression on AKT phosphorylation, contributing to the anti-cancer effects.	dapt	50-54	AKT serine/threonine kinase 1	Homo sapiens	87-90