PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21398698-8 2011 DDR1 activation suppressed genotoxic-mediated cell death, whereas Notch1 inhibition by a gamma-secretase inhibitor, DAPT, enhanced cell death in response to stress. dapt 116-120 notch receptor 1 Homo sapiens 66-72 21929751-10 2011 Lastly, DAPT-mediated inhibition of Notch-1 resulted in HCT116 tumor growth arrest and down regulation of Notch-1 via a miR-144 dependent mechanism. dapt 8-12 notch receptor 1 Homo sapiens 36-43 21929751-10 2011 Lastly, DAPT-mediated inhibition of Notch-1 resulted in HCT116 tumor growth arrest and down regulation of Notch-1 via a miR-144 dependent mechanism. dapt 8-12 notch receptor 1 Homo sapiens 106-113 21876634-6 2011 Furthermore, blocking Notch-1 activation with a gamma-secretase inhibitor, DAPT, downregulated LSF expression in HepG2 cells. dapt 75-79 notch receptor 1 Homo sapiens 22-29 21466361-8 2011 Inhibition of Notch signaling with gamma-secretase inhibitors, L-685,458 and DAPT, prevented Hes1 nuclear translocation but neither suppressed growth nor induced cell death. dapt 77-81 notch receptor 1 Homo sapiens 14-19 20351093-11 2010 By using gamma-secretase inhibitor (N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester) that interfered Notch signaling and RNA interference that knockdown Notch1 expression, we confirmed that downregulation of Notch1 reduced the invasiveness of the cells. dapt 36-105 notch receptor 1 Homo sapiens 230-236 21512281-8 2011 RAGE-induced ALP and Msx2 expression was completely abrogated by DAPT, an inhibitor of the Notch signaling pathway. dapt 65-69 notch receptor 1 Homo sapiens 91-96 19953094-8 2010 Rho activity assessment on Notch1 inhibition with DAPT shows decreased RhoC activity. dapt 50-54 notch receptor 1 Homo sapiens 27-33 20117093-7 2010 Down-regulation of Notch1 expression by DAPT was able to substantially inhibit cell growth, induce G1 cell cycle arrest and induce cell apoptosis in A2780 in dose- and time-dependent manner. dapt 40-44 notch receptor 1 Homo sapiens 19-25 19542446-5 2009 The blockade of Notch signaling pathways using a gamma-secretase inhibitor, DAPT (N-[N-(3,5-difluorophenacetyl-l-alanyl)]-S-phenylglycine t-butyl ester), reduces the survival of GC-B cells in the presence of FDC/HK cells. dapt 76-80 notch receptor 1 Homo sapiens 16-21 19662631-6 2009 Treatment of macrophages with the gamma-secretase inhibitor DAPT, which prevents the cleavage and activation of Notch receptors, inhibits all these processes, diminishing NF-kappaB activity following LPS stimulation. dapt 60-64 notch receptor 1 Homo sapiens 112-117 18593982-9 2008 Br4 cells were more migratory and invasive than MDA-MB-435 cells in collagen and Matrigel Transwell assays, and the migration and invasion of Br4 cells were significantly inhibited by inactivation of Notch signaling using DAPT, a gamma-secretase inhibitor, and RNA interference-mediated knockdown of Jagged 2 and Notch1. dapt 222-226 notch receptor 1 Homo sapiens 200-205 19550121-13 2009 DAPT can enhance DDP-sensitivity of Tb3.1 cells via blocking Notch1 signaling. dapt 0-4 notch receptor 1 Homo sapiens 61-67 18320325-11 2008 NS-398 and DAPT inhibited cell proliferation and induced apoptosis in a dose time-dependent manner accompanied by significantly decreased Notch1 activity (P < 0.01), and resulted in a significant down-regulation of Hes1 and NF-kappaB2 (P < 0.01). dapt 11-15 notch receptor 1 Homo sapiens 138-144 18991739-13 2008 DAPT, an inhibitor of Notch activity, when added contemporary to HNE, further increased cell growth inhibition, without affecting apoptosis. dapt 0-4 notch receptor 1 Homo sapiens 22-27 18593982-9 2008 Br4 cells were more migratory and invasive than MDA-MB-435 cells in collagen and Matrigel Transwell assays, and the migration and invasion of Br4 cells were significantly inhibited by inactivation of Notch signaling using DAPT, a gamma-secretase inhibitor, and RNA interference-mediated knockdown of Jagged 2 and Notch1. dapt 222-226 notch receptor 1 Homo sapiens 313-319 33802884-8 2021 Combination treatment of TSE1 with the Notch1 signaling inhibitor tert-butyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate (DAPT), or the Akt signaling inhibitor wortmannin, showed a stronger inhibition toward HIF-1alpha activation compared with single compound treatment. dapt 66-162 notch receptor 1 Homo sapiens 39-45 18456406-5 2008 Nevertheless, blockage of Notch enzymatic cleavage with gamma-seacretase inhibitors, DAPT and L-685,458, neither interrupted resveratrol-caused cellular events nor affected MB cell growth. dapt 85-89 notch receptor 1 Homo sapiens 26-31 33945189-12 2021 miR-29a-5p-mimics, si-GSAP and DAPT (gamma-secretase inhibitor) inhibited PTH-induced gamma-secretase activation, thus blocking Notch1 pathway activation to inhibit EndMT in vitro. dapt 31-35 notch receptor 1 Homo sapiens 128-134 33945189-14 2021 Blocking Notch1 pathway activation via AAV-miR-29a and DAPT inhibited valvular EndMT. dapt 55-59 notch receptor 1 Homo sapiens 9-15 33791203-3 2021 The gamma secretase inhibitors, BMS-708163, GSI-IX, PF-3084014, and RO4929097 abrogated the enzalutamide resistance by inhibiting Notch1 or/and Notch4 in vitro, with GSI-IX and RO4929097 being more effective than BMS-708163 and PF-3084014 in reliving bone metastasis in vivo. dapt 44-50 notch receptor 1 Homo sapiens 130-136 33791203-4 2021 In conclusion, the Notch1 and Notch4 inhibitors GSI-IX and RO4929097 are promising therapeutic agents for the treatment of CRPC. dapt 48-54 notch receptor 1 Homo sapiens 19-25 34954251-7 2022 Interestingly, Lp(a) activated Notch1 signaling, resulting in cell calcification, which was inhibited by the Notch1 signaling inhibitor, DAPT. dapt 137-141 notch receptor 1 Homo sapiens 31-37 34954251-7 2022 Interestingly, Lp(a) activated Notch1 signaling, resulting in cell calcification, which was inhibited by the Notch1 signaling inhibitor, DAPT. dapt 137-141 notch receptor 1 Homo sapiens 109-115 33907837-8 2021 Importantly, we noted that treatment with a Notch signaling inhibitor DAPT produced very similar anticancer efficacy in both HepG2 and Huh-7 cell lines, and administration of DAPT also efficiently suppressed HepG2 xenograft outgrowth. dapt 70-74 notch receptor 1 Homo sapiens 44-49 34295560-10 2021 The activation of Notch1/Hes1 or AKT/mTOR signaling removed the inhibitory effect of DAPT on the proliferation and migration of HepG2 cells, as well as the inhibitory properties of DAPT on the expression of MMPs and adhesion molecules. dapt 181-185 notch receptor 1 Homo sapiens 18-24 35508987-17 2022 Critically, both suppression of Notch pathway activation by DAPT treatment or downregulation of Notch1 expression by shRNA reverses NDR1 enhanced BCSC properties. dapt 60-64 notch receptor 1 Homo sapiens 32-37 34804926-11 2021 The gamma-secretase inhibitor DAPT significantly reversed RBM8A-enhanced GBM cell proliferation and invasion, and was associated with down-regulation of p-STAT3 and Notch1 protein. dapt 30-34 notch receptor 1 Homo sapiens 165-171 34335900-11 2021 In addition, the Notch1/Hes1 pathway inhibitor DAPT significantly downregulated the expression of FOXP3 in a dose-dependent manner. dapt 47-51 notch receptor 1 Homo sapiens 17-23 34295560-9 2021 DAPT significantly inhibited the proliferation and migration of HepG2 cells in a dose-dependent manner, accompanied by the suppression of Notch1/Hes1 signaling, inactivation of AKT/mTOR signaling, downregulation of MMPs, and decreased expression of adhesion molecules. dapt 0-4 notch receptor 1 Homo sapiens 138-144 34295560-10 2021 The activation of Notch1/Hes1 or AKT/mTOR signaling removed the inhibitory effect of DAPT on the proliferation and migration of HepG2 cells, as well as the inhibitory properties of DAPT on the expression of MMPs and adhesion molecules. dapt 85-89 notch receptor 1 Homo sapiens 18-24 35212196-7 2022 The function of Notch1 was evaluated with gamma-secretase inhibitor DAPT and genetic knockdown using shRNA strategy. dapt 68-72 notch receptor 1 Homo sapiens 16-22 35212196-10 2022 Blockade of Notch1 using DAPT and Notch1 shRNA efficiently abrogated mTORC1 activation and pro-inflammatory T cell differentiation. dapt 25-29 notch receptor 1 Homo sapiens 12-18 33907837-8 2021 Importantly, we noted that treatment with a Notch signaling inhibitor DAPT produced very similar anticancer efficacy in both HepG2 and Huh-7 cell lines, and administration of DAPT also efficiently suppressed HepG2 xenograft outgrowth. dapt 175-179 notch receptor 1 Homo sapiens 44-49 33907837-9 2021 To this end, we anticipated that AB4 and DAPT may act on the same signaling pathway, probably through inhibition of the Notch pathway. dapt 41-45 notch receptor 1 Homo sapiens 120-125 33976158-3 2021 Moreover, RFC4 is a functional transcriptional target gene of Notch1 signaling, forming a positive feedback loop between high RFC4 and NICD1 levels and sustained overactivation of Notch signaling, which not only leads to NSCLC tumorigenicity and metastasis but also confers NSCLC cell resistance to treatment with the clinically tested drug DAPT against NICD1 synthesis. dapt 341-345 notch receptor 1 Homo sapiens 62-68 33976158-3 2021 Moreover, RFC4 is a functional transcriptional target gene of Notch1 signaling, forming a positive feedback loop between high RFC4 and NICD1 levels and sustained overactivation of Notch signaling, which not only leads to NSCLC tumorigenicity and metastasis but also confers NSCLC cell resistance to treatment with the clinically tested drug DAPT against NICD1 synthesis. dapt 341-345 notch receptor 1 Homo sapiens 62-67 33468121-17 2021 RESV partly rescued the DAPT or Notch1 siRNA induced apoptosis by activating Notch1 signaling. dapt 24-28 notch receptor 1 Homo sapiens 77-83 33649841-9 2021 In addition, the GASC1 inhibitor caffeic acid and/or the NOTCH1 inhibitor DAPT (a gamma-Secretase Inhibitor), efficiently suppressed the human glioma xenograft tumors. dapt 74-78 notch receptor 1 Homo sapiens 57-63 33610041-4 2021 Firstly, we found that Notch1 signaling is activated in free fatty acids-treated HepG2 cells accompanied by lipid accumulation, apoptosis, oxidative stress, and mitochondrial damage, which could be alleviated by Notch1 inhibitor N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT). dapt 229-298 notch receptor 1 Homo sapiens 23-29 33610041-4 2021 Firstly, we found that Notch1 signaling is activated in free fatty acids-treated HepG2 cells accompanied by lipid accumulation, apoptosis, oxidative stress, and mitochondrial damage, which could be alleviated by Notch1 inhibitor N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT). dapt 229-298 notch receptor 1 Homo sapiens 212-218 33610041-4 2021 Firstly, we found that Notch1 signaling is activated in free fatty acids-treated HepG2 cells accompanied by lipid accumulation, apoptosis, oxidative stress, and mitochondrial damage, which could be alleviated by Notch1 inhibitor N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT). dapt 300-304 notch receptor 1 Homo sapiens 23-29 33610041-4 2021 Firstly, we found that Notch1 signaling is activated in free fatty acids-treated HepG2 cells accompanied by lipid accumulation, apoptosis, oxidative stress, and mitochondrial damage, which could be alleviated by Notch1 inhibitor N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT). dapt 300-304 notch receptor 1 Homo sapiens 212-218 33081033-6 2020 RNA-sequencing studies of HCC-1599 and MB-157 cells exposed to ATRA and DAPT and ATRA+DAPT demonstrate that the two compounds act on common gene sets, some of which belong to the NOTCH1 pathway. dapt 72-76 notch receptor 1 Homo sapiens 179-185 33081033-6 2020 RNA-sequencing studies of HCC-1599 and MB-157 cells exposed to ATRA and DAPT and ATRA+DAPT demonstrate that the two compounds act on common gene sets, some of which belong to the NOTCH1 pathway. dapt 86-90 notch receptor 1 Homo sapiens 179-185 32695658-5 2020 In A375 with B-raf mutation, DAPT decreased the level of NOTCH1, NOTH2, and HES1 as downstream genes of the Notch pathway. dapt 29-33 notch receptor 1 Homo sapiens 57-63 32695658-5 2020 In A375 with B-raf mutation, DAPT decreased the level of NOTCH1, NOTH2, and HES1 as downstream genes of the Notch pathway. dapt 29-33 notch receptor 1 Homo sapiens 108-113 32695658-11 2020 Our data supported that the long-term and not short-term inhibition of Notch by DAPT may enhance tumor growth and motility through up-regulation of AXIN1, CSNK2A3, and CEBPA2 genes in B-raf mutated A375 cells. dapt 80-84 notch receptor 1 Homo sapiens 71-76 32319581-10 2020 The Notch-1 signaling pathway was activated to induce EMT in forskolin-induced VM process in CC cells, and VM and EMT could be reversed by using the gamma-secretase inhibitor DAPT to block the Notch-1 pathway. dapt 175-179 notch receptor 1 Homo sapiens 4-11 32169443-12 2020 DAPT counteracted the effects of Notch-1 activation on PCNA and IL-33. dapt 0-4 notch receptor 1 Homo sapiens 33-40 32151947-12 2020 Genetic and pharmacological Notch pathway inhibition by DAPT and Notch-1 siRNA exhibited decreased curcumin mediated neuroprotection. dapt 56-60 notch receptor 1 Homo sapiens 28-33 32601154-10 2020 Inhibition of RAGE and Notch1 by FPS-ZM1 (N-Benzyl-4-chloro-N-cyclohexylbenzamide) and DAPT (N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenyl glycine t-butylester), respectively, abrogates AGE-induced Notch activation and EMT. dapt 87-91 notch receptor 1 Homo sapiens 23-28 32601154-14 2020 Pharmacological inhibition of Notch signaling by DAPT ameliorates AGE-induced podocytopathy and fibrosis. dapt 49-53 notch receptor 1 Homo sapiens 30-35 32319581-10 2020 The Notch-1 signaling pathway was activated to induce EMT in forskolin-induced VM process in CC cells, and VM and EMT could be reversed by using the gamma-secretase inhibitor DAPT to block the Notch-1 pathway. dapt 175-179 notch receptor 1 Homo sapiens 193-200 31863921-0 2020 DAPT reverses the Th17/Treg imbalance in experimental autoimmune uveitis in vitro via inhibiting Notch signaling pathway. dapt 0-4 notch receptor 1 Homo sapiens 97-102 32116749-9 2020 We also demonstrated a 3-fold induction (p < 0.001) of human coronary VSMC Notch signaling by ECs at the in vitro MEJ, which was completely blocked by the Notch inhibitor, DAPT (p < 0.01). dapt 172-176 notch receptor 1 Homo sapiens 75-80 32116749-9 2020 We also demonstrated a 3-fold induction (p < 0.001) of human coronary VSMC Notch signaling by ECs at the in vitro MEJ, which was completely blocked by the Notch inhibitor, DAPT (p < 0.01). dapt 172-176 notch receptor 1 Homo sapiens 155-160 31527287-4 2020 Blocking of the notch signaling pathway (NSP) either by Notch1 siRNA or by DAPT treatment increased the proliferation rate while decreasing apoptosis and led to activation of the NF-kappaB signaling pathway in HSCs co-cultured with BMSCs. dapt 75-79 notch receptor 1 Homo sapiens 16-21 31863921-7 2020 By contrast, inhibition of Notch signaling by DAPT can efficiently decrease Th17 cell response, downregulate the expression of Notch1, DLL4, IL-17 and the transcription of RORgammat, reduce Th17 levels and restore the CD4+/CD8+, Th17/Treg balance. dapt 46-50 notch receptor 1 Homo sapiens 27-32 31863921-7 2020 By contrast, inhibition of Notch signaling by DAPT can efficiently decrease Th17 cell response, downregulate the expression of Notch1, DLL4, IL-17 and the transcription of RORgammat, reduce Th17 levels and restore the CD4+/CD8+, Th17/Treg balance. dapt 46-50 notch receptor 1 Homo sapiens 127-133 31073804-8 2019 hDPSCs were cultured in neural induction medium and N-[N-(3,5-difluorophenacetyl-L-alanyl)]-Sphenylglycine t-butyl ester (DAPT) was applied to impede Notch signaling during transformation into spheres or on the formed neurospheres. dapt 122-126 notch receptor 1 Homo sapiens 150-155 31158382-9 2019 Moreover, DAPT, a specific inhibitor of Notch signaling pathway, reversed LEC-EMT. dapt 10-14 notch receptor 1 Homo sapiens 40-45 31357779-9 2019 An inhibition of Notch signaling pathway with DAPT had reduced the relative expression level of TLR4 mRNA (2.58 +- 1.36 vs. 4.34 +- 1.88, P < 0.05), protein expression and phosphorylation of NF-B in CD14(+) monocytes of chronic hepatitis C patients. dapt 46-50 notch receptor 1 Homo sapiens 17-22 31417656-4 2019 Therefore, in this study, we explored the effects of Notch signaling pathway in cervical cancer by curcumin mediated PDT with/without Notch receptor blocker (DAPT), and hope to elucidate its mechanism. dapt 158-162 notch receptor 1 Homo sapiens 53-58 31417656-7 2019 mRNA and protein expression of gene Notch-1 and its downstream NF-kappaB and VEGF were observed with RT-PCR, immunohistochemical staining and Western-blot with/without inhibition of Notch signaling pathway by DAPT, both in vivo and in vitro experiments. dapt 209-213 notch receptor 1 Homo sapiens 36-41 30839137-10 2019 DAPT (the specific blocker of Notch1) and BMSC-conditioned medium (BMSC-CM) could significantly prevent the apoptotic effect and oxidative stress injury on NSCs that were treated with H2 O2 . dapt 0-4 notch receptor 1 Homo sapiens 30-36 31073804-10 2019 Treatment of the formed neurospheres with DAPT resulted in the cleaved Notch1 reduction, G0/G1 arrest and a decline in L-lactate production. dapt 42-46 notch receptor 1 Homo sapiens 71-77 31028097-8 2019 Therapeutic inhibition of Notch1 activity with gamma secretase inhibitors RO4929097 or DAPT in prostate cancer cells further results in decreased proliferative abilities. dapt 87-91 notch receptor 1 Homo sapiens 26-32 31023175-9 2019 Results: RSV promoted neurite outgrowth of cortical neurons, and this effect could be partially prevented by the Notch 1 pathway inhibitor, DAPT. dapt 140-144 notch receptor 1 Homo sapiens 113-120 31023175-11 2019 In addition, we observed that the levels of both Notch 1 and Hes 1 in cortical neurons were increased after RSV, but sharply decreased after DAPT treatment. dapt 141-145 notch receptor 1 Homo sapiens 49-56 31093499-6 2019 DAPT, a Notch signaling inhibitor, exerted similar effects in SCLC. dapt 0-4 notch receptor 1 Homo sapiens 8-13 31298400-11 2019 Using DAPT to block Notch1 signaling could reverse the protective effects of Berberine and Hesperidin. dapt 6-10 notch receptor 1 Homo sapiens 20-26 30988066-6 2019 Tregs/Th17 percentages, transcriptional factors, and cytokines production were investigated in response to the stimulation of Notch signaling inhibitor DAPT. dapt 152-156 notch receptor 1 Homo sapiens 126-131 30895661-6 2019 Pathway inhibitor DAPT was employed to confirm the regulatory effect of KK-LC-1 on the downstream Notch signalling. dapt 18-22 notch receptor 1 Homo sapiens 98-103 30690027-9 2019 In this study, we observed an enhanced DNA damage and cellular apoptosis via the ATM/CHK2/P53 pathway(s) in HeLa and SiHa cells treated with cisplatin combined with DAPT of Notch1 inhibitor. dapt 165-169 notch receptor 1 Homo sapiens 173-179 30259982-7 2019 The inhibitor of Notch-1, DAPT, reduced all the effects of Jagged-1 on nasal epithelial cells. dapt 26-30 notch receptor 1 Homo sapiens 17-24 30998155-5 2019 Then, the expression of Notch1 in cells was inhibited by notch1 inhibitor DAPT and RNA interference, the above-motioned experiments should be repeated. dapt 74-78 notch receptor 1 Homo sapiens 24-30 30998155-5 2019 Then, the expression of Notch1 in cells was inhibited by notch1 inhibitor DAPT and RNA interference, the above-motioned experiments should be repeated. dapt 74-78 notch receptor 1 Homo sapiens 57-63 30590978-8 2019 Blocking Notch receptor activation with the gamma-secretase inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester) diminished these effects. dapt 70-74 notch receptor 1 Homo sapiens 9-14 30590978-8 2019 Blocking Notch receptor activation with the gamma-secretase inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester) diminished these effects. dapt 76-145 notch receptor 1 Homo sapiens 9-14 30407728-0 2019 gamma-secretase inhibitor DAPT mitigates cisplatin-induced acute kidney injury by suppressing Notch1 signaling. dapt 26-30 notch receptor 1 Homo sapiens 94-100 30336218-9 2019 Finally, consistently with the results from Notch inhibitor DAPT treatment, rapamycin suppressed the migration of HUVECs in vitro. dapt 60-64 notch receptor 1 Homo sapiens 44-49 30407728-10 2019 siRNA-mediated Dll1 knockdown and DAPT attenuated cisplatin-induced Notch1 cleavage and cytotoxicity in HK-2 cells. dapt 34-38 notch receptor 1 Homo sapiens 68-74 29804421-6 2018 Conclusions: DAPT can effectively block the Notch signaling pathway and inhibit the proliferation of cervical cancer cell line Me180.The application of DAPT to inhibit Notch signaling pathway after photodynamic therapy can achieve synergistic effect, which is mainly related to the down-regulation of the expression of Notch1 and NF-kappaB.Notch signaling pathway may be one of the targets of curcumin-PDT photodynamic therapy. dapt 13-17 notch receptor 1 Homo sapiens 44-49 30230583-4 2018 VEGF (100 ng/mL) and gamma-secretase inhibitor (DAPT) (10 muM) was used to active and inhibit VEGF-Notch signaling in AA MSCs, respectively. dapt 48-52 notch receptor 1 Homo sapiens 99-104 29956731-11 2018 Additionally, the combination of quercetin-3-methyl ether and a secretase inhibitor (DAPT) exhibited additive suppression of the expression of Notch1, PI3K, Akt and mammalian target of rapamycin and a more marked inhibitory effect on cell proliferation and colony formation compared with either drug alone. dapt 85-89 notch receptor 1 Homo sapiens 143-149 30015939-6 2018 Additionally, 1,25(OH)2D3 and/or DAPT reduced the expression of Notch1, Notch2, Jagged1 and Jagged2. dapt 33-37 notch receptor 1 Homo sapiens 64-70 30151432-8 2018 HESCs were treated with N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester (DAPT) and valproic acid (VPA) to, respectively, suppress and induce Notch-1 activation. dapt 24-93 notch receptor 1 Homo sapiens 163-170 30483127-7 2018 Meanwhile, overexpression of Notch1 suppressed and inhibition of Notch1 promoted rosiglitazone-induced adipogenic differentiation in TSCs, and the pro-adipogenic effects of the Notch inhibitor DAPT were associated with the activation of autophagy. dapt 193-197 notch receptor 1 Homo sapiens 29-35 30483127-7 2018 Meanwhile, overexpression of Notch1 suppressed and inhibition of Notch1 promoted rosiglitazone-induced adipogenic differentiation in TSCs, and the pro-adipogenic effects of the Notch inhibitor DAPT were associated with the activation of autophagy. dapt 193-197 notch receptor 1 Homo sapiens 65-71 30483127-7 2018 Meanwhile, overexpression of Notch1 suppressed and inhibition of Notch1 promoted rosiglitazone-induced adipogenic differentiation in TSCs, and the pro-adipogenic effects of the Notch inhibitor DAPT were associated with the activation of autophagy. dapt 193-197 notch receptor 1 Homo sapiens 29-34 29804421-0 2018 [Inhibitory effect of DAPT on Notch signaling pathway in curcumin mediated photodynamic therapy for cervical cancer xenografts in nude mice]. dapt 22-26 notch receptor 1 Homo sapiens 30-35 29804421-6 2018 Conclusions: DAPT can effectively block the Notch signaling pathway and inhibit the proliferation of cervical cancer cell line Me180.The application of DAPT to inhibit Notch signaling pathway after photodynamic therapy can achieve synergistic effect, which is mainly related to the down-regulation of the expression of Notch1 and NF-kappaB.Notch signaling pathway may be one of the targets of curcumin-PDT photodynamic therapy. dapt 13-17 notch receptor 1 Homo sapiens 168-173 29804421-6 2018 Conclusions: DAPT can effectively block the Notch signaling pathway and inhibit the proliferation of cervical cancer cell line Me180.The application of DAPT to inhibit Notch signaling pathway after photodynamic therapy can achieve synergistic effect, which is mainly related to the down-regulation of the expression of Notch1 and NF-kappaB.Notch signaling pathway may be one of the targets of curcumin-PDT photodynamic therapy. dapt 13-17 notch receptor 1 Homo sapiens 168-173 29804421-6 2018 Conclusions: DAPT can effectively block the Notch signaling pathway and inhibit the proliferation of cervical cancer cell line Me180.The application of DAPT to inhibit Notch signaling pathway after photodynamic therapy can achieve synergistic effect, which is mainly related to the down-regulation of the expression of Notch1 and NF-kappaB.Notch signaling pathway may be one of the targets of curcumin-PDT photodynamic therapy. dapt 152-156 notch receptor 1 Homo sapiens 44-49 29804421-6 2018 Conclusions: DAPT can effectively block the Notch signaling pathway and inhibit the proliferation of cervical cancer cell line Me180.The application of DAPT to inhibit Notch signaling pathway after photodynamic therapy can achieve synergistic effect, which is mainly related to the down-regulation of the expression of Notch1 and NF-kappaB.Notch signaling pathway may be one of the targets of curcumin-PDT photodynamic therapy. dapt 152-156 notch receptor 1 Homo sapiens 168-173 29804421-6 2018 Conclusions: DAPT can effectively block the Notch signaling pathway and inhibit the proliferation of cervical cancer cell line Me180.The application of DAPT to inhibit Notch signaling pathway after photodynamic therapy can achieve synergistic effect, which is mainly related to the down-regulation of the expression of Notch1 and NF-kappaB.Notch signaling pathway may be one of the targets of curcumin-PDT photodynamic therapy. dapt 152-156 notch receptor 1 Homo sapiens 168-173 29047105-5 2018 Notch signaling inhibition using a gamma-secretase inhibitor (GSI-IX, DAPT) decreased tumour burden in the mouse model after prophylactic treatment. dapt 62-68 notch receptor 1 Homo sapiens 0-5 29230705-11 2018 Silencing of Notch1 signaling with inhibitor DAPT, NF-kappaB activation and LPS-induced inflammatory response were obviously attenuated, whereas Notch1 activator Jagged1 could markedly restore NF-kappaB activity and LPS-induced inflammatory response (P < 0.05 for all). dapt 45-49 notch receptor 1 Homo sapiens 13-19 29286081-12 2018 Furthermore, inhibition of Notch1 signaling by N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (inhibitor of Notch signaling) counteracted the effects of Ficz on the development of TJs in hypoxic Caco-2 cells. dapt 47-116 notch receptor 1 Homo sapiens 27-33 29286081-12 2018 Furthermore, inhibition of Notch1 signaling by N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (inhibitor of Notch signaling) counteracted the effects of Ficz on the development of TJs in hypoxic Caco-2 cells. dapt 47-116 notch receptor 1 Homo sapiens 27-32 29286145-10 2018 These effects were further confirmed by the Notch-1 inhibitor DAPT. dapt 62-66 notch receptor 1 Homo sapiens 44-51 29451718-8 2018 The Notch inhibitor DAPT reduced the biological effects of KIAA0247 knockdown, suggesting that KIAA0247 decreased the carcinogenic activity of NSCLC cells through downregulation of Notch signaling. dapt 20-24 notch receptor 1 Homo sapiens 4-9 29451718-8 2018 The Notch inhibitor DAPT reduced the biological effects of KIAA0247 knockdown, suggesting that KIAA0247 decreased the carcinogenic activity of NSCLC cells through downregulation of Notch signaling. dapt 20-24 notch receptor 1 Homo sapiens 181-186 29523162-3 2018 In this study, our aim was to evaluate the possible inhibitory effect of Notch1 signaling inhibitor, gamma-secretase inhibitor DAPT, on psoriatic Th17 cell differentiation and function in a mouse model of psoriasis-like skin inflammation. dapt 127-131 notch receptor 1 Homo sapiens 73-79 29047105-5 2018 Notch signaling inhibition using a gamma-secretase inhibitor (GSI-IX, DAPT) decreased tumour burden in the mouse model after prophylactic treatment. dapt 70-74 notch receptor 1 Homo sapiens 0-5 29123981-8 2017 Expression of cyclin D1, PDGFR, Notch1, and Hes1 was markedly enhanced by PDGF-BB but inhibited by DAPT. dapt 99-103 notch receptor 1 Homo sapiens 32-38 29049420-5 2017 Here we show that blocking of Notch-1 with N-[(3,5-Difluorophenyl) acetyl]-L-alanyl-2-phenylglycine-1,1-dimethylethyl ester (DAPT) in LPS activated BV-2 microglia not only suppressed Notch intracellular domain (NICD) and Hes-1 protein expression, but also that of GSK-3beta. dapt 125-129 notch receptor 1 Homo sapiens 30-37 27878968-7 2017 Furthermore, CMK effect on ciliated cell differentiation was reversed by a Notch inhibitor N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester (DAPT). dapt 162-166 notch receptor 1 Homo sapiens 75-80 27878968-7 2017 Furthermore, CMK effect on ciliated cell differentiation was reversed by a Notch inhibitor N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester (DAPT). dapt 91-160 notch receptor 1 Homo sapiens 75-80 29253571-6 2018 Our data suggest that Notch1/Hes1 signaling pathway is deactivated using DAPT with a low dose of Triton-X100 in this cancer cells. dapt 73-77 notch receptor 1 Homo sapiens 22-28 29344233-10 2017 Downregulation of the Notch signaling pathway by LDM was enhanced through combination with N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester. dapt 91-160 notch receptor 1 Homo sapiens 22-27 28927121-10 2017 The levels of Jagged1, Notch1, VEGF protein and the interaction between Jagged1 and Notch1 in the DAPT inhibitor control group and drug serum group were significantly lower than in the control serum group (P<0.01). dapt 98-102 notch receptor 1 Homo sapiens 84-90 28487945-3 2017 Nox4 and the Notch pathway were inhibited by N-acetylcysteine (NAC), diphenylene iodonium (DPI) or gamma-secretase inhibitor (DAPT). dapt 126-130 notch receptor 1 Homo sapiens 13-18 28947978-5 2017 Furthermore, inhibition of NOTCH signal pathway in SW480 which has abundant NICD1 expression, was performed by transfection of siNICD1 or DAPT, gamma secretase inhibitor, treatment. dapt 138-142 notch receptor 1 Homo sapiens 27-32 28526405-4 2017 Importantly, these changes in expression are significantly suppressed by the NOTCH1 inhibitor DAPT. dapt 94-98 notch receptor 1 Homo sapiens 77-83 28498402-8 2017 RUNX3 expression was reduced in si-RUNX3 and si-RUNX3+DAPT group but the expression levels of Notch signaling related genes were markedly increased in si-RUNX3 group or decreased in DAPT and si-NC+DAPT group, as compared with those in the control group (all P<0.05). dapt 182-186 notch receptor 1 Homo sapiens 94-99 28498402-8 2017 RUNX3 expression was reduced in si-RUNX3 and si-RUNX3+DAPT group but the expression levels of Notch signaling related genes were markedly increased in si-RUNX3 group or decreased in DAPT and si-NC+DAPT group, as compared with those in the control group (all P<0.05). dapt 182-186 notch receptor 1 Homo sapiens 94-99 28487945-9 2017 Inhibition of the Notch pathway via DAPT increased Bcl-2 expression, decreased Bax and cleaved caspase-3 levels and prevented HKC cell apoptosis. dapt 36-40 notch receptor 1 Homo sapiens 18-23 27939630-4 2017 The presence of DAPT antagonized the above changes of cycle arrest, proliferation inhibition, and expressions of Dll4, Notch1, Cleaved-Notch1, Hes1, and p21 caused by endosulfan; however, NAC could attenuate LDH release; ROS and malondialdehyde production; apoptosis; and the expression levels of Dll4, Notch1, Cleaved-Notch1, Notch4, and Hes1 induced by endosulfan. dapt 16-20 notch receptor 1 Homo sapiens 119-125 28130038-7 2017 Furthermore, when pretreated with DAPT, a gamma-secretase inhibitor, the Notch1 signaling pathway was blocked in APL cells, followed by the reduction of ATPR-induced autophagy and differentiation. dapt 34-38 notch receptor 1 Homo sapiens 73-79 28238274-3 2017 Monocytes were treated with Notch-1 inhibitors DAPT or siRNA. dapt 47-51 notch receptor 1 Homo sapiens 28-35 28238274-9 2017 We conclude that blocking the Notch-1 pathway with DAPT or siRNA attenuates pro-inflammatory cytokines, enhances M2 macrophage differentiation, and increases anti-inflammatory cytokines in primary human monocytes. dapt 51-55 notch receptor 1 Homo sapiens 30-37 27939630-4 2017 The presence of DAPT antagonized the above changes of cycle arrest, proliferation inhibition, and expressions of Dll4, Notch1, Cleaved-Notch1, Hes1, and p21 caused by endosulfan; however, NAC could attenuate LDH release; ROS and malondialdehyde production; apoptosis; and the expression levels of Dll4, Notch1, Cleaved-Notch1, Notch4, and Hes1 induced by endosulfan. dapt 16-20 notch receptor 1 Homo sapiens 135-141 27939630-4 2017 The presence of DAPT antagonized the above changes of cycle arrest, proliferation inhibition, and expressions of Dll4, Notch1, Cleaved-Notch1, Hes1, and p21 caused by endosulfan; however, NAC could attenuate LDH release; ROS and malondialdehyde production; apoptosis; and the expression levels of Dll4, Notch1, Cleaved-Notch1, Notch4, and Hes1 induced by endosulfan. dapt 16-20 notch receptor 1 Homo sapiens 135-141 27939630-4 2017 The presence of DAPT antagonized the above changes of cycle arrest, proliferation inhibition, and expressions of Dll4, Notch1, Cleaved-Notch1, Hes1, and p21 caused by endosulfan; however, NAC could attenuate LDH release; ROS and malondialdehyde production; apoptosis; and the expression levels of Dll4, Notch1, Cleaved-Notch1, Notch4, and Hes1 induced by endosulfan. dapt 16-20 notch receptor 1 Homo sapiens 135-141 27176495-3 2016 Noteworthy, blocking of Notch signaling with DAPT resulted in growth inhibition in ICN1-overexpressing CaSki and HT-3 cells. dapt 45-49 notch receptor 1 Homo sapiens 24-29 27821106-7 2016 Second, GSI IX, which is a gamma-secretase-inhibitor, was used for Notch signaling blockade in the following experiment. dapt 8-14 notch receptor 1 Homo sapiens 67-72 27677287-9 2016 Compared to untreated control cells, DAPT dose dependently increased Numb expression and inhibited Notch1, Hes1, and Hes5 expressions at 2 Gy (P < 0.05). dapt 37-41 notch receptor 1 Homo sapiens 99-105 27176495-8 2016 Notch signaling inhibitor DAPT partly reversed VPA-induced Snail1 upregulation in HeLa cells. dapt 26-30 notch receptor 1 Homo sapiens 0-5 26783939-9 2016 Notch1 was inhibited by siRNA or DAPT. dapt 33-37 notch receptor 1 Homo sapiens 0-6 27102300-9 2016 The Notch inhibitor DAPT also prevented tumor recurrence in resistant xenograft tumors. dapt 20-24 notch receptor 1 Homo sapiens 4-9 27108536-4 2016 NOTCH1 inhibitor DAPT (GSI-IX) significantly reduces CSCs population and tumor self-renewal ability in vitro and in vivo. dapt 17-21 notch receptor 1 Homo sapiens 0-6 27108536-4 2016 NOTCH1 inhibitor DAPT (GSI-IX) significantly reduces CSCs population and tumor self-renewal ability in vitro and in vivo. dapt 23-29 notch receptor 1 Homo sapiens 0-6 26783939-13 2016 Notch1 inhibition by siRNA or DAPT could reduce these inflammatory responses by reduction of NF-kappaB phosphorylation, upregulation of IkBalpha expression, and inhibition of nuclear translocation of NF-kappaB, while Notch1 activation by DLL-4 had an adverse effect. dapt 30-34 notch receptor 1 Homo sapiens 0-6 26540052-7 2015 On the other hand, Notch1 inhibition (DAPT) dose-dependently decreases survivin, stimulates differentiation, and reduces keratinocyte proliferation in samples from donors of all ages. dapt 38-42 notch receptor 1 Homo sapiens 19-25 26988682-3 2016 The calcified hVICs were further divided into calcified hVICs group and inhibited calcified hVICs by adding specific Notch1 inhibitor DAPT (50 mumol/L(4 mul/hole))groups and cultured for another 7 days. dapt 134-138 notch receptor 1 Homo sapiens 117-123 26988682-10 2016 (2) After treatment with DAPT, the calcification and the expression of Notch1, p-NF-kappaB, BMP-2 and BMP-4 were significantly decreased compared to calcification group (all P<0.05). dapt 25-29 notch receptor 1 Homo sapiens 71-77 26094772-9 2015 Using DAPT (Notch1 inhibitor) to knock down Notch1 expression, morphological and molecular typical changes of the EMT were detected in vitro. dapt 6-10 notch receptor 1 Homo sapiens 12-18 25914224-11 2015 Experiments with the pan-Notch inhibitor DAPT, and soluble Jagged-1-Fc protein provided evidence that Notch-1 signaling activates CD44, Slug, and Smad-3 via a cascade of other Notch-receptors through induction of Jagged-1 expression. dapt 41-45 notch receptor 1 Homo sapiens 102-109 26722328-7 2015 DAPT treatment inhibited the expression of the Notch1 downstream target Hes1 and EMT markers, suppressed the properties of CSCs and impaired the invasion and proliferation capabilities of CD44+ cells. dapt 0-4 notch receptor 1 Homo sapiens 47-53 26362310-7 2015 In the breast cancer line T47D, doxorubicin activated Notch1 and, critically, inhibition of Notch1 activation with the gamma-secretase inhibitor DAPT abolished the doxorubicin-induced increase in MRP1 expression and function (t-test p < 0.05), resulting in enhanced cellular retention of doxorubicin and increased doxorubicin-induced apoptosis (t-test p = 0.0002). dapt 145-149 notch receptor 1 Homo sapiens 54-60 26362310-7 2015 In the breast cancer line T47D, doxorubicin activated Notch1 and, critically, inhibition of Notch1 activation with the gamma-secretase inhibitor DAPT abolished the doxorubicin-induced increase in MRP1 expression and function (t-test p < 0.05), resulting in enhanced cellular retention of doxorubicin and increased doxorubicin-induced apoptosis (t-test p = 0.0002). dapt 145-149 notch receptor 1 Homo sapiens 92-98 26094772-9 2015 Using DAPT (Notch1 inhibitor) to knock down Notch1 expression, morphological and molecular typical changes of the EMT were detected in vitro. dapt 6-10 notch receptor 1 Homo sapiens 44-50 26094772-14 2015 The in vivo data showed that inhibition of Notch signaling by DAPT treatment effectively suppressed metastatic tumor growth, metabolic activity and invasion. dapt 62-66 notch receptor 1 Homo sapiens 43-48 25967959-8 2015 The protective effect of spironolactone against EndMT could be attenuated by blocking the Notch signal pathway with DAPT (p<0.01). dapt 116-120 notch receptor 1 Homo sapiens 90-95 25637797-11 2015 It turned out that DAPT significantly prevented the Notch1 activation in hUCMSCs after co-culture with OGD neurons. dapt 19-23 notch receptor 1 Homo sapiens 52-58 25637797-13 2015 Regarding how Notch1 signaling was linked with VEGF-A secretion, we provided some clue that Notch1 effector Hes1 mRNA expression was significantly up-regulated by OGD-neuron co-culturing and down-regulated after additional treatment of DAPT. dapt 236-240 notch receptor 1 Homo sapiens 14-20 25637797-13 2015 Regarding how Notch1 signaling was linked with VEGF-A secretion, we provided some clue that Notch1 effector Hes1 mRNA expression was significantly up-regulated by OGD-neuron co-culturing and down-regulated after additional treatment of DAPT. dapt 236-240 notch receptor 1 Homo sapiens 92-98 25742746-6 2015 Inhibition of FoxM1 by Thiostrepton and of Notch1 by DAPT downregulated the sphere formation ability of cells. dapt 53-57 notch receptor 1 Homo sapiens 43-49 25775018-10 2015 Vascular collapse in zebrafish embryos was partially rescued by global Notch inhibition with DAPT suggesting that disruption of normal Notch signaling by CSA may be linked to vascular collapse. dapt 93-97 notch receptor 1 Homo sapiens 71-76 25775018-10 2015 Vascular collapse in zebrafish embryos was partially rescued by global Notch inhibition with DAPT suggesting that disruption of normal Notch signaling by CSA may be linked to vascular collapse. dapt 93-97 notch receptor 1 Homo sapiens 135-140 25088840-7 2015 Furthermore, this difference was eliminated by adding the Notch1 signaling pathway inhibitor DAPT to the 3D static culture. dapt 93-97 notch receptor 1 Homo sapiens 58-64 26062426-4 2015 After Notch pathway was blocked with gamma-secretase inhibitor DAPT, expressions of Notch intracellular domain (NICD), Delta-like 4 (DLL4), hairy enhancer of split 1 (Hes1), matrix metalloproteinase 9 (MMP-9) in IL-23-treated TE-1 cells were measured by Western blotting. dapt 63-67 notch receptor 1 Homo sapiens 6-11 25073953-10 2014 Moreover, the inhibition of Notch1 signaling by DAPT leads to the arrest of cell proliferation and induces apoptosis leading to the upregulation of MUC2, a secretory cell lineage marker. dapt 48-52 notch receptor 1 Homo sapiens 28-34 24805975-5 2014 When treated with DAPT, a specific inhibitor of Notch receptor cleavage, expression of Notch1 and Jagged2 were downregulated in a dose-dependent manner, which was accompanied by substantial cell growth arrest, as indicated by the Cell Counting kit-8 assay. dapt 18-22 notch receptor 1 Homo sapiens 87-93 24939218-5 2014 The notch1 inhibitor DAPT and the downregulation of notch1 by shRNA promoted osteogenesis in MM-MSCs. dapt 21-25 notch receptor 1 Homo sapiens 4-10 24814170-5 2014 METHODS: Condylar cartilage explants were cultured over serum-free DMEM containing either 0 or 50nM DAPT, a Notch signal inhibitor. dapt 100-104 notch receptor 1 Homo sapiens 108-113 25063285-8 2014 The expression of protein and mRNA of Notch-1, Delta-1 and Hes-1 were gradually downregulated with the increase of DAPT doses. dapt 115-119 notch receptor 1 Homo sapiens 38-54 25063285-9 2014 CONCLUSIONS: DAPT can downregulate these key factor in Notch signaling pathway, reduce the TSC of CD133+ and inhibit the proliferation of SHG-44 cells. dapt 13-17 notch receptor 1 Homo sapiens 55-60 24805975-9 2014 The inhibition of the Notch signaling pathway by DAPT represents a potentially attractive strategy for the therapy of retinoblastoma. dapt 49-53 notch receptor 1 Homo sapiens 22-27 25286679-8 2014 RT-PCR analysis demonstrated that the expression of Notch1 mRNA decreased significantly in the DAPT groups, with an inhibition rate of 10.23%, 20.50%, and 38.83% for the three DAPT groups, respectively. dapt 95-99 notch receptor 1 Homo sapiens 52-58 25286679-8 2014 RT-PCR analysis demonstrated that the expression of Notch1 mRNA decreased significantly in the DAPT groups, with an inhibition rate of 10.23%, 20.50%, and 38.83% for the three DAPT groups, respectively. dapt 176-180 notch receptor 1 Homo sapiens 52-58 25286679-9 2014 Western blot results demonstrated that the expression of Notch1 protein decreased significantly, with an inhibition rate of 12.89%, 27.47%, and 49.84% for the three DAPT groups, respectively. dapt 165-169 notch receptor 1 Homo sapiens 57-63 25286679-10 2014 CONCLUSION: Gamma-secretase inhibitor DAPT can block Notch signaling pathway, inhibit proliferation, and induce apoptosis of SKOV3 cells through down-regulation of the expression of Notch1. dapt 38-42 notch receptor 1 Homo sapiens 53-58 25286679-10 2014 CONCLUSION: Gamma-secretase inhibitor DAPT can block Notch signaling pathway, inhibit proliferation, and induce apoptosis of SKOV3 cells through down-regulation of the expression of Notch1. dapt 38-42 notch receptor 1 Homo sapiens 182-188 24932308-8 2014 Using MTT, Transwell and clonality assays, DAPT was found to inhibit the expression of the Notch1 downstream target, Hes1, and impair the ability of the GC cell lines to migrate, invade and proliferate. dapt 43-47 notch receptor 1 Homo sapiens 91-97 24932308-11 2014 In conclusion, DAPT inhibits the Notch1 signaling pathway, as well as the growth, invasion, metastasis and EMT of GC cells. dapt 15-19 notch receptor 1 Homo sapiens 33-39 24386256-9 2013 Notch1 siRNA (in vitro) or DAPT (a known Notch1 inhibitor, in vivo) further enhanced the antitumor activity of SIL, and recombinant Jagged1 protein (a known Notch ligand in vitro) attenuated the antitumor activity of SIL. dapt 27-31 notch receptor 1 Homo sapiens 41-47 24114531-4 2014 Notch loss-of-function (DAPT and dominant negative [R218H] RBP-Jk [CSL/CBF1]) showed that a functional leptin-Notch signaling axis was involved in the proliferation and migration of E0771 cells. dapt 24-28 notch receptor 1 Homo sapiens 0-5 23881612-6 2014 Treatment of DAPT (a gamma-secretase inhibitor) or TAPI-2 (a hydroxamate-based inhibitor of MMPs, tumor necrosis factor alpha converting enzyme and ADAM17) reduces Notch1 shedding and activation which results in attenuation of stemness genes and CD133. dapt 13-17 notch receptor 1 Homo sapiens 164-170 24284009-5 2014 When the NSCs were pre-treated with the Notch pathway inhibitor DAPT, the activation of Notch1 was blocked, lower NSCs differentiation was detected and the neurotrophic effect was also abolished. dapt 64-68 notch receptor 1 Homo sapiens 40-45 24284009-5 2014 When the NSCs were pre-treated with the Notch pathway inhibitor DAPT, the activation of Notch1 was blocked, lower NSCs differentiation was detected and the neurotrophic effect was also abolished. dapt 64-68 notch receptor 1 Homo sapiens 88-94 24189144-7 2014 Luciferase reporter analyses suggested basal, canonical Notch activity in SGHPL-5 cells and primary cells that was increased upon seeding on DLL4-coated dishes and diminished in the presence of the Notch/gamma-secretase inhibitors N-[N-(3,5-difluorophenacetyl-l-alanyl)]-S-phenylglycine t-butyl ester (DAPT) or L-685,458. dapt 302-306 notch receptor 1 Homo sapiens 56-61 24851694-8 2014 DAPT treatment decreased MPP(+)-induced apoptosis (3.10% +- 0.21% vs 35.50% +- 4.98%, 19.20% +- 2.98%, both P < 0.05) and the expressions of Notch-1, Jagged-1 and Hes-1 in SH-SY5Y cell. dapt 0-4 notch receptor 1 Homo sapiens 144-151 24851694-10 2014 DAPT inhibits Notch signaling pathway and protects SH-SY5Y cell from MPP(+)-induced apoptosis. dapt 0-4 notch receptor 1 Homo sapiens 14-19 24535252-0 2014 Pretreatment with the gamma-secretase inhibitor DAPT sensitizes drug-resistant ovarian cancer cells to cisplatin by downregulation of Notch signaling. dapt 48-52 notch receptor 1 Homo sapiens 134-139 24535252-1 2014 Notch signaling is implicated in ovarian cancer tumorigenesis and inhibition of Notch signaling with gamma-secretase inhibitor DAPT resulted in reduction of tumor cell viability and induction of apoptosis in ovarian cancer cells. dapt 127-131 notch receptor 1 Homo sapiens 80-85 24535252-8 2014 Pretreatment of ovarian cancer cell lines with DAPT and then with cisplatin downregulated Notch1 and Hes1 expression dose- and time-dependently. dapt 47-51 notch receptor 1 Homo sapiens 90-96 24535252-9 2014 The current data demonstrate that DAPT pretreatment was able to sensitize cisplatin-resistant human ovarian cancer cells to cisplatin by downregulation of Notch signaling. dapt 34-38 notch receptor 1 Homo sapiens 155-160 23899513-14 2013 Blocking Notch1 activation by DAPT alone inhibited NIKS cellular proliferation (P < 0.01%). dapt 30-34 notch receptor 1 Homo sapiens 9-15 23219912-5 2013 DAPT and Notch1 siRNA significantly inhibited OSI and the expression of Notch1 and Hes1. dapt 0-4 notch receptor 1 Homo sapiens 72-78 23578365-8 2013 In vitro, we used gamma-secretase inhibitor N-S-phenyl-glycine-t-butyl ester (DAPT) to block Notch1 signaling in Jurkat cells. dapt 78-82 notch receptor 1 Homo sapiens 93-99 23578365-15 2013 Blocking Notch1 signal by DAPT inhibited the proliferation of Jurkat cells and induced G0/G1 phase cell cycle arrest and apoptosis. dapt 26-30 notch receptor 1 Homo sapiens 9-15 22931655-5 2012 The expressions of Notch1 and Hes1 proteins were gradually downregulated with the increase of DAPT concentration. dapt 94-98 notch receptor 1 Homo sapiens 19-25 22809957-6 2012 The in vivo expression of Dll4 but not of Jagged1 was well correlated with expression of IL-33 in quiescent vessels, and subcutaneous injection of DAPT in healthy skin reduced IL-33 expression, indicating that Notch signaling was involved. dapt 147-151 notch receptor 1 Homo sapiens 210-215 22290418-7 2012 We show that NICD transduction modulates known direct and indirect Notch target genes and antagonizes the DAPT-mediated inhibition of Notch signaling on the transcriptional level. dapt 106-110 notch receptor 1 Homo sapiens 134-139 22275240-10 2012 Finally, 3% hypoxia-induced angiogenesis, endothelial cell migration, endothelial cell invasion, and proMMP-2 and proMMP-9 activities were inhibited by Notch-1 siRNA and/or the gamma-secretase inhibitor DAPT. dapt 203-207 notch receptor 1 Homo sapiens 152-159