PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23489689-7	2013	The level of IL-10 produced by the treated cells was also enhanced, whereas the expression of IL-17 was prominently attenuated, which could be offset by anti-Jagged-1 antibody or DAPT.	dapt	179-183	interleukin 17A	Homo sapiens	94-99	
25485537-11	2015	After inactivating Notch signal by DAPT, Th17 cells and Th17/Treg ratio were dose dependently decreased and accompanied by the reduction of IL-17 in culture supernatants and RORgammat mRNA expression in ITP patients.	dapt	35-39	interleukin 17A	Homo sapiens	140-145	
25485537-13	2015	We also present evidence that the effect of DAPT inhibition on the Th17 cell response was associated with downregulation of RORgammat and IL-17 transcription using human in vitro polarization.	dapt	44-48	interleukin 17A	Homo sapiens	138-143	
31863921-7	2020	By contrast, inhibition of Notch signaling by DAPT can efficiently decrease Th17 cell response, downregulate the expression of Notch1, DLL4, IL-17 and the transcription of RORgammat, reduce Th17 levels and restore the CD4+/CD8+, Th17/Treg balance.	dapt	46-50	interleukin 17A	Homo sapiens	141-146	
30988066-9	2019	DAPT treatment did not affect frequency of either circulating Tregs or Th17 cells, however, reduced FoxP3/RORgammat mRNA expression and interleukin (IL)-35/IL-17 production in purified CD4+ T cells from GC patients.	dapt	0-4	interleukin 17A	Homo sapiens	156-161	
28157396-7	2017	DAPT treatment reduced Th17 response by downregulation of RORgammat expression and interleukin (IL)-17/IL-22 secretion.	dapt	0-4	interleukin 17A	Homo sapiens	83-102	
29686529-5	2018	DAPT treatment resulted in the obvious downregulation of Th17 cell percentage in cocultured CD4+ T cells, RORgammat and IL-17 mRNA levels, and IL-17 concentration in cell-free supernatant from cocultured CD4+ T cells of PV patients in a dose-dependent manner, while there was no significant influence on Treg cell percentage, Foxp3, and IL-10 expression, therefore leading to the recovery of Th17/Treg immune imbalance.	dapt	0-4	interleukin 17A	Homo sapiens	120-125	
29686529-5	2018	DAPT treatment resulted in the obvious downregulation of Th17 cell percentage in cocultured CD4+ T cells, RORgammat and IL-17 mRNA levels, and IL-17 concentration in cell-free supernatant from cocultured CD4+ T cells of PV patients in a dose-dependent manner, while there was no significant influence on Treg cell percentage, Foxp3, and IL-10 expression, therefore leading to the recovery of Th17/Treg immune imbalance.	dapt	0-4	interleukin 17A	Homo sapiens	143-148