PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9774254-6 1998 The hypoxia-elicited pressor response was prominently inhibited by (i) nordihydroguaiaretic acid (50-150 microM), an inhibitor of lipoxygenase and cyclooxygenase and (ii) methoxsalen (100 microM) and 1-aminobenzotriazole (1-10 mM), two inhibitors of cytochrome P450-derived metabolites. Masoprocol 71-96 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 130-142 15388505-6 2005 Indomethacin-resistant relaxations were further reduced by the lipoxygenase inhibitors cinnamyl-3,4-dihydroxy-cyanocinnamate (CDC; 1 muM), nordihydroguaiaretic acid (NDGA; 1 microM), and ebselen (1 microM). Masoprocol 139-164 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 63-75 15388505-6 2005 Indomethacin-resistant relaxations were further reduced by the lipoxygenase inhibitors cinnamyl-3,4-dihydroxy-cyanocinnamate (CDC; 1 muM), nordihydroguaiaretic acid (NDGA; 1 microM), and ebselen (1 microM). Masoprocol 166-170 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 63-75 10803760-2 2000 Inhibitors of cyclooxygenase (indomethacin and diclofenac sodium) and lipoxygenase pathways (nordihydroguaiaretic acid, caffeic acid, and eicosapentaenoic acid) reduced H/R-induced LDH release in a dose-dependent manner, whereas an inhibitor of cytochrome P-450 monooxygenase pathway ethoxyresorufin was not effective. Masoprocol 93-118 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 30-82 11035536-10 2000 NDGA selectively inhibited LOX activity without affecting COX activity. Masoprocol 0-4 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 27-30 9268230-5 1997 The lipoxygenase inhibitor nordihydroguaiaretic acid (NDGA) selectively attenuated the angiotensin II-induced contractions in rabbit aortic rings from the control group only in the presence of the endothelium, whereas it had no effect on the responses to angiotensin II in the cholesterol group (with or without endothelium). Masoprocol 27-52 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 4-16 9268230-5 1997 The lipoxygenase inhibitor nordihydroguaiaretic acid (NDGA) selectively attenuated the angiotensin II-induced contractions in rabbit aortic rings from the control group only in the presence of the endothelium, whereas it had no effect on the responses to angiotensin II in the cholesterol group (with or without endothelium). Masoprocol 54-58 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 4-16 8591886-11 1996 The combined cyclooxygenase/lipoxygenase inhibitor BW 755C and the lipoxygenase inhibitor nordihydroguaiaretic acid completely blocked arachidonic acid-induced contractions in females. Masoprocol 90-115 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 67-79 8961076-8 1996 Whereas the lipoxygenase inhibitor, nordihydroguaiaretic acid (5 x 10(-5) M), caused a slight increase in the contractions to norepinephrine in cholesterol-fed rabbits compared with normal rabbits, the cytochrome P450 epoxygenase inhibitor, metyrapone (10(-4) M), produced a greater enhancement of norepinephrine-induced contractions in cholesterol-fed rabbits but had no effect on responses in the normal rabbits. Masoprocol 36-61 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 12-24 8931100-6 1996 The lipoxygenase inhibitor, nordihydroguaiaretic acid (NDGA, 20 nmol/l), significantly enhanced the 5-HT-induced pressor response in normal rings while significantly attenuating those responses in diabetic rings. Masoprocol 28-53 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 4-16 8931100-6 1996 The lipoxygenase inhibitor, nordihydroguaiaretic acid (NDGA, 20 nmol/l), significantly enhanced the 5-HT-induced pressor response in normal rings while significantly attenuating those responses in diabetic rings. Masoprocol 55-59 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 4-16 3138902-3 1988 Lipoxygenase inhibitors (5,8,11,14-eicosatetraynoic acid, nordihydroguaiaretic acid) strongly inhibit the lipoxin formation. Masoprocol 58-83 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 0-12 2342774-7 1990 The phospholipase A2 inhibitor, quinacrine, and the lipoxygenase inhibitor, nordihydroguaiaretic acid, blocked the induction of SOD, while the cyclooxygenase inhibitor, indomethacin, did not. Masoprocol 76-101 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 52-64 3395165-8 1988 The lipoxygenase-inhibitor nordihydroguaiaretic acid (NDGA), inhibited the responses to ACh and A23187, but did not reduce the responses to PGI2. Masoprocol 27-52 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 4-16 3395165-8 1988 The lipoxygenase-inhibitor nordihydroguaiaretic acid (NDGA), inhibited the responses to ACh and A23187, but did not reduce the responses to PGI2. Masoprocol 54-58 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 4-16 2452609-4 1988 Nordihydroguaiaretic acid (NDGA), an inhibitor of lipoxygenase, significantly reduced the dilator responses to ACh, A23187 and SP, but did not reduce the responses to sodium nitrite. Masoprocol 0-25 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 50-62 2452609-4 1988 Nordihydroguaiaretic acid (NDGA), an inhibitor of lipoxygenase, significantly reduced the dilator responses to ACh, A23187 and SP, but did not reduce the responses to sodium nitrite. Masoprocol 27-31 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 50-62 2488013-8 1989 However, the induction of SOD was prevented by the phospholipase A2 inhibitor, quinacrine, and the lipoxygenase inhibitor, nordihydroguaiaretic acid (NDGA). Masoprocol 123-148 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 99-111 2488013-8 1989 However, the induction of SOD was prevented by the phospholipase A2 inhibitor, quinacrine, and the lipoxygenase inhibitor, nordihydroguaiaretic acid (NDGA). Masoprocol 150-154 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 99-111 3139810-7 1988 NDGA was the most potent inhibitor of lipoxygenase reactions, but was not selective. Masoprocol 0-4 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 38-50 3102978-7 1986 Endothelium-dependent relaxations induced by larger concentrations of thimerosal, as well as relaxations produced by acetylcholine, were inhibited by the antioxidant and lipoxygenase inhibitor nordihydroguaiaretic acid, by haemoglobin, and by the inhibitor of soluble guanylate cyclase methylene blue. Masoprocol 193-218 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 170-182 2821856-5 1987 In the presence of 2 structurally unrelated lipoxygenase inhibitors (nordihydroguaiaretic acid and AA-861), the leukotriene release was nearly completely inhibited and the AA-induced severe increase in vascular permeability was significantly reduced (2.5- to 3-fold rise in Kf,c, compared to a greater than 10-fold increase in Kf,c in the absence of lipoxygenase inhibition). Masoprocol 69-94 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 44-56 2821856-5 1987 In the presence of 2 structurally unrelated lipoxygenase inhibitors (nordihydroguaiaretic acid and AA-861), the leukotriene release was nearly completely inhibited and the AA-induced severe increase in vascular permeability was significantly reduced (2.5- to 3-fold rise in Kf,c, compared to a greater than 10-fold increase in Kf,c in the absence of lipoxygenase inhibition). Masoprocol 69-94 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 350-362 3037070-4 1987 Hypoxia-induced neutrophil uptake was prevented by nordihydroguaiaretic acid (NDGA) or diethylcarbamazine (DEC), two structurally different inhibitors of lipoxygenase. Masoprocol 51-76 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 154-166 3037070-4 1987 Hypoxia-induced neutrophil uptake was prevented by nordihydroguaiaretic acid (NDGA) or diethylcarbamazine (DEC), two structurally different inhibitors of lipoxygenase. Masoprocol 78-82 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 154-166 6289942-8 1982 Inhibition of the lipoxygenase pathway with eicosatetraynoic acid (ETYA) or nordihydroguaiaretic acid (NDGA) did not affect the inhibition caused by arachidonic acid, so it is unlikely that a product of this pathway is responsible for the inhibition. Masoprocol 103-107 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 18-30 3924036-3 1985 The antimycin A-resistant oxygen uptake was further inhibited by the lipoxygenase inhibitors salicylhydroxamic acid, 5,8,11,14-eicosatetraynoic acid, nordihydroguaiaretic acid, 4-nitrocatechol or propylgallate by about 20-30% corresponding to 5-7% of the total oxygen uptake. Masoprocol 150-175 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 69-81 3086125-2 1986 Lipoxygenase is inhibited by nordihydroguaiaretic acid (NDGA), 3-amino-1-(m-(trifluoromethyl)phenyl)-2-pyrazoline (BW755C), 5,8,11,14-eicosatetraynoic acid (ETYA), salicylhydroxamate (SHAM) or hemin. Masoprocol 29-54 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 0-12 3086125-2 1986 Lipoxygenase is inhibited by nordihydroguaiaretic acid (NDGA), 3-amino-1-(m-(trifluoromethyl)phenyl)-2-pyrazoline (BW755C), 5,8,11,14-eicosatetraynoic acid (ETYA), salicylhydroxamate (SHAM) or hemin. Masoprocol 56-60 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 0-12 3002157-6 1985 The lipoxygenase inhibitor NDGA, indomethacin at high doses (50 microM), diethylcarbamazine and the phospholipase inhibitor dibromoacetophenone, inhibited the MCM dependent synthesis of collagenase in chondrocytes. Masoprocol 27-31 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 4-16 6411897-6 1983 The combined lipoxygenase/cyclooxygenase inhibitors BW 755 and eicosa-5,8,11,14-tetraynoic acid and the lipoxygenase inhibitor nordihydroguaiaretic acid also blocked the stimulation of PG synthesis by lys-bradykinin. Masoprocol 127-152 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 104-116