PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33462346-2 2021 DPYD and UGT1A1 variants are relevant predictors of fluoropyrimidine and irinotecan-associated adverse events (AEs). 2-fluoropyrimidine 52-68 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 9-15 34996412-1 2022 BACKGROUND: Pharmacogenetic (PGx) testing for germline variants in the DPYD and UGT1A1 genes can be used to guide fluoropyrimidine and irinotecan dosing, respectively. 2-fluoropyrimidine 114-130 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 80-86 32666389-0 2020 Impact of single-heterozygous UGT1A1 on the clinical outcomes of irinotecan monotherapy after fluoropyrimidine and platinum-based combination therapy for gastric cancer: a multicenter retrospective study. 2-fluoropyrimidine 94-110 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 30-36 30339275-7 2019 In patients receiving fluoropyrimidine/irinotecan, the incremental cost between DPYD variant and UGT1A1*28/*28 carriers and noncarriers was $2,975. 2-fluoropyrimidine 22-38 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 97-103 30339275-8 2019 This study suggests that the toxicity management costs during fluoropyrimidine-based therapy are associated with DPYD and UGT1A1*28 variants and supports the utility of genotyping. 2-fluoropyrimidine 62-78 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 122-128