PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29406528-0	2018	Corrigendum: Taheebo Polyphenols Attenuate FFA-Induced Inflammation in Murine and Human Macrophage Cell Lines As Inhibitor of COX-2.	Flufenamic Acid	43-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131	
10866999-3	2000	Here, we report that flufenamic acid shows two opposing effects on COX-2 expression; it induces COX-2 expression in the colon cancer cell line (HT-29) and macrophage cell line (RAW 264.7); conversely, it inhibits tumor necrosis factor alpha (TNFalpha)- or lipopolysaccharide (LPS)-induced COX-2 expression.	Flufenamic Acid	21-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72	
14510637-3	2004	With the detergent genapol X-100 (2 mM) present, the potencies of nimesulide, ibuprofen, flufenamic acid, niflumic acid and naproxen were increased over 100-fold against Cox-2 and titration curve shapes changed, so that maximal inhibition now approached 100%.	Flufenamic Acid	89-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-175	
14510637-9	2004	The increases in potency of ibuprofen, flufenamic acid, isoxicam and niflumic acid towards Cox-2 and ibuprofen towards Cox-1 were accompanied by a change from time-independent to time-dependent inhibition.	Flufenamic Acid	39-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96	
10866999-10	2000	Furthermore, the results suggest that the anti-inflammatory effects of flufenamic acid and some other NSAIDs are due to their inhibitory action on the mitogen-induced expression of COX-2 and downstream markers of inflammation in addition to their inhibitory effect on COX enzyme activity.	Flufenamic Acid	71-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186	
10866999-3	2000	Here, we report that flufenamic acid shows two opposing effects on COX-2 expression; it induces COX-2 expression in the colon cancer cell line (HT-29) and macrophage cell line (RAW 264.7); conversely, it inhibits tumor necrosis factor alpha (TNFalpha)- or lipopolysaccharide (LPS)-induced COX-2 expression.	Flufenamic Acid	21-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101	
10866999-3	2000	Here, we report that flufenamic acid shows two opposing effects on COX-2 expression; it induces COX-2 expression in the colon cancer cell line (HT-29) and macrophage cell line (RAW 264.7); conversely, it inhibits tumor necrosis factor alpha (TNFalpha)- or lipopolysaccharide (LPS)-induced COX-2 expression.	Flufenamic Acid	21-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101