PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28500718-8	2017	Retinyl ester levels were much higher in Rpe65-/- mice compared to wild type and kept increasing with age.	Retinyl ester	0-13	retinal pigment epithelium 65	Mus musculus	41-46	
28500718-9	2017	The results suggest that the RPE65 role in retinyl ester homeostasis extends beyond enabling the formation of 11-cis retinal.	Retinyl ester	43-56	retinal pigment epithelium 65	Mus musculus	29-34	
15765048-14	2005	A naturally arising mouse Rpe65 mutation provides a good model for studying the pathology of human RPE65 mutations and the effects of retinyl ester accumulation.	Retinyl ester	134-147	retinal pigment epithelium 65	Mus musculus	26-31	
17012256-1	2006	RPE65 is the retinal isomerase essential for conversion of all-trans-retinyl ester to 11-cis-retinol in the visual cycle.	Retinyl ester	59-82	retinal pigment epithelium 65	Mus musculus	0-5	
16026160-6	2005	Thus, the results imply that as a chaperone each RPE65 molecule can deliver retinyl ester to the isomerohydrolase at a rate of 10 molecules/min; should RPE65 itself be identified as the isomerase, each copy must be able to produce at least 10 molecules of 11-cis-retinal per minute.	Retinyl ester	76-89	retinal pigment epithelium 65	Mus musculus	49-54	
25538117-5	2015	Lecithin:retinol acyltransferase (LRAT) is the enzyme that traps vitamin A (all-trans-retinol) from the circulation and photoreceptor cells to produce the esterified substrate for retinoid isomerase (RPE65), which converts all-trans-retinyl ester into 11-cis-retinol.	Retinyl ester	223-246	retinal pigment epithelium 65	Mus musculus	200-205	
14532273-0	2004	Rpe65 is a retinyl ester binding protein that presents insoluble substrate to the isomerase in retinal pigment epithelial cells.	Retinyl ester	11-24	retinal pigment epithelium 65	Mus musculus	0-5	
15109394-11	2004	Delivery of rAAV.RPE65 also resulted in a decrease in retinyl ester lipid droplets and an increase in short wavelength cone opsin-positive cells, suggesting that the recovery of RPE65 expression has long-term benefits for retinal health.	Retinyl ester	54-67	retinal pigment epithelium 65	Mus musculus	17-22	
12657577-7	2003	In Rpe65(+/+) mice, the average SA of RPE ((3)H)retinyl ester similarly exhibited an early peak (4.5 hours) and by 48 hours declined to approximately 6% to 10% of the peak.	Retinyl ester	48-61	retinal pigment epithelium 65	Mus musculus	3-8	
12657577-16	2003	In 3-month Rpe65(+/+) mice, the observed relationship between the SAs of retinaldehydes in the retina and of RPE retinyl ester is consistent with a last-in/first-out processing of all-trans retinol to 11-cis retinal within normally functioning RPE.	Retinyl ester	113-126	retinal pigment epithelium 65	Mus musculus	11-16