PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28089597-1 2017 Serine racemase is the pyridoxal 5"-phosphate dependent enzyme that catalyzes both production and catabolism of d-serine, a co-agonist of the NMDA glutamate receptors. D-serine 112-120 serine racemase Homo sapiens 0-15 27387750-3 2016 We show that mammalian serine racemase (SRR), the primary enzyme responsible for brain d-Ser production, catalyses Asp racemization via a two-base mechanism. D-serine 87-92 serine racemase Homo sapiens 23-38 27585868-1 2017 BACKGROUND: Serine racemase (SR) catalyzes the production of d-serine, a co-agonist of the N-methyl-d-aspartate receptor (NMDAR). D-serine 61-69 serine racemase Homo sapiens 12-27 27387750-3 2016 We show that mammalian serine racemase (SRR), the primary enzyme responsible for brain d-Ser production, catalyses Asp racemization via a two-base mechanism. D-serine 87-92 serine racemase Homo sapiens 40-43 26941605-1 2016 D-serine is an endogenous coagonist at the glycine site of synaptic NMDA receptors (NMDARs), synthesized by serine racemase (SR) through conversion of L-serine. D-serine 0-8 serine racemase Homo sapiens 108-123 27742076-3 2016 Results from several laboratories using different strategies now show that the biosynthetic enzyme of d-serine, serine racemase (SR), is expressed almost entirely by neurons, with few astrocytes appearing to contain d-serine. D-serine 102-110 serine racemase Homo sapiens 112-127 27742076-3 2016 Results from several laboratories using different strategies now show that the biosynthetic enzyme of d-serine, serine racemase (SR), is expressed almost entirely by neurons, with few astrocytes appearing to contain d-serine. D-serine 102-110 serine racemase Homo sapiens 129-131 27742076-3 2016 Results from several laboratories using different strategies now show that the biosynthetic enzyme of d-serine, serine racemase (SR), is expressed almost entirely by neurons, with few astrocytes appearing to contain d-serine. D-serine 216-224 serine racemase Homo sapiens 112-127 27742076-3 2016 Results from several laboratories using different strategies now show that the biosynthetic enzyme of d-serine, serine racemase (SR), is expressed almost entirely by neurons, with few astrocytes appearing to contain d-serine. D-serine 216-224 serine racemase Homo sapiens 129-131 27493223-1 2016 Serine racemase catalyzes both the synthesis and the degradation of d-serine, an obligatory co-agonist of the glutamatergic NMDA receptors. D-serine 68-76 serine racemase Homo sapiens 0-15 27493223-10 2016 This newly recognized allosteric site might be exploited for the design of high-affinity serine racemase effectors to finely modulate d-serine homeostasis. D-serine 134-142 serine racemase Homo sapiens 89-104 26954593-7 2016 Inactivation of one of these risk genes that encodes serine racemase, which synthesizes D-serine, an NMDAR co-agonist, reproduces the synaptic pathology of schizophrenia. D-serine 88-96 serine racemase Homo sapiens 53-68 26133542-2 2016 d-Serine is synthesized by human serine racemase (SR). D-serine 0-8 serine racemase Homo sapiens 33-48 26133542-2 2016 d-Serine is synthesized by human serine racemase (SR). D-serine 0-8 serine racemase Homo sapiens 50-52 26941605-1 2016 D-serine is an endogenous coagonist at the glycine site of synaptic NMDA receptors (NMDARs), synthesized by serine racemase (SR) through conversion of L-serine. D-serine 0-8 serine racemase Homo sapiens 125-127 26941605-4 2016 We thus hypothesize that D-serine and SR (D-serine/SR) are associated with glutamatergic synaptic development. D-serine 42-50 serine racemase Homo sapiens 38-40 26941605-5 2016 Using morphological and molecular studies in cortical neuronal cultures, we demonstrate that D-serine/SR are associated with PSD-95 and NMDARs in postsynaptic neurons and with glutamatergic synapse stability during synaptic development. D-serine 93-101 serine racemase Homo sapiens 102-104 26941605-8 2016 More interestingly, endogenous D-serine and SR colocalize with PSD-95 in the postsynaptic terminals of glutamatergic synapses during early and late synaptic development, implicating involvement of D-serine/SR in glutamatergic synaptic development. D-serine 197-205 serine racemase Homo sapiens 44-46 26941605-9 2016 Exogenous application of D-serine enhances the interactions of SR with PSD-95 and NR1, and increases the number of VGLUT1- and PSD-95-positive glutamatergic synapses, suggesting that exogenous D-serine enhances postsynaptic SR/PSD-95 signaling and stabilizes glutamatergic synapses during cortical synaptic development. D-serine 25-33 serine racemase Homo sapiens 63-65 26941605-9 2016 Exogenous application of D-serine enhances the interactions of SR with PSD-95 and NR1, and increases the number of VGLUT1- and PSD-95-positive glutamatergic synapses, suggesting that exogenous D-serine enhances postsynaptic SR/PSD-95 signaling and stabilizes glutamatergic synapses during cortical synaptic development. D-serine 25-33 serine racemase Homo sapiens 224-226 26941605-9 2016 Exogenous application of D-serine enhances the interactions of SR with PSD-95 and NR1, and increases the number of VGLUT1- and PSD-95-positive glutamatergic synapses, suggesting that exogenous D-serine enhances postsynaptic SR/PSD-95 signaling and stabilizes glutamatergic synapses during cortical synaptic development. D-serine 193-201 serine racemase Homo sapiens 224-226 26941605-12 2016 Taken together, our findings demonstrate that D-serine/SR are associated with PSD-95 and NMDARs in postsynaptic neurons and with glutamatergic synapse stability during synaptic development, implicating D-serine/SR as regulators of cortical synaptic and circuit development. D-serine 46-54 serine racemase Homo sapiens 55-57 26941605-12 2016 Taken together, our findings demonstrate that D-serine/SR are associated with PSD-95 and NMDARs in postsynaptic neurons and with glutamatergic synapse stability during synaptic development, implicating D-serine/SR as regulators of cortical synaptic and circuit development. D-serine 202-210 serine racemase Homo sapiens 55-57 26851299-0 2016 Nuclear compartmentalization of serine racemase regulates d-serine production. D-serine 58-66 serine racemase Homo sapiens 32-47 26553873-0 2015 Nuclear Compartmentalization of Serine Racemase Regulates D-Serine Production: IMPLICATIONS FOR N-METHYL-D-ASPARTATE (NMDA) RECEPTOR ACTIVATION. D-serine 58-66 serine racemase Homo sapiens 32-47 26553873-3 2015 D-Serine is synthesized by the enzyme serine racemase (SR), which directly converts L-serine to D-serine. D-serine 0-8 serine racemase Homo sapiens 38-53 26553873-3 2015 D-Serine is synthesized by the enzyme serine racemase (SR), which directly converts L-serine to D-serine. D-serine 0-8 serine racemase Homo sapiens 55-57 26553873-3 2015 D-Serine is synthesized by the enzyme serine racemase (SR), which directly converts L-serine to D-serine. D-serine 96-104 serine racemase Homo sapiens 38-53 26553873-3 2015 D-Serine is synthesized by the enzyme serine racemase (SR), which directly converts L-serine to D-serine. D-serine 96-104 serine racemase Homo sapiens 55-57 26553873-5 2015 Here, we investigate possible mechanisms regulating the synthesis of D-serine by SR in paradigms relevant to neurotoxicity. D-serine 69-77 serine racemase Homo sapiens 81-83 25666758-5 2015 Suggestive evidence of association was found for the D-serine plasma-CSF ratio at the D-amino-acid oxidase (DAO) gene (beta=-0.28; P=9.08 x 10(-8)), whereas a variant in SRR (that encodes serine racemase and is associated with schizophrenia) constituted the most strongly associated locus for the L-serine to D-serine ratio in CSF. D-serine 53-61 serine racemase Homo sapiens 188-203 25493718-1 2015 Serine racemase (SerR) is a pyridoxal-5"-phosphate (PLP)-dependent enzyme catalyzing the racemization of l-Ser to d-Ser. D-serine 114-119 serine racemase Homo sapiens 0-15 25870284-3 2015 Here we show that d-serine production in astrocytes is modulated by the interaction between the D-serine synthetic enzyme serine racemase (SRR) and a glycolytic enzyme, glyceraldehyde 3-phosphate dehydrogenase (GAPDH). D-serine 18-26 serine racemase Homo sapiens 122-137 25870284-3 2015 Here we show that d-serine production in astrocytes is modulated by the interaction between the D-serine synthetic enzyme serine racemase (SRR) and a glycolytic enzyme, glyceraldehyde 3-phosphate dehydrogenase (GAPDH). D-serine 18-26 serine racemase Homo sapiens 139-142 25870284-3 2015 Here we show that d-serine production in astrocytes is modulated by the interaction between the D-serine synthetic enzyme serine racemase (SRR) and a glycolytic enzyme, glyceraldehyde 3-phosphate dehydrogenase (GAPDH). D-serine 96-104 serine racemase Homo sapiens 122-137 25870284-3 2015 Here we show that d-serine production in astrocytes is modulated by the interaction between the D-serine synthetic enzyme serine racemase (SRR) and a glycolytic enzyme, glyceraldehyde 3-phosphate dehydrogenase (GAPDH). D-serine 96-104 serine racemase Homo sapiens 139-142 25870284-8 2015 Thus, astrocytic production of D-serine is modulated by glycolytic activity via interactions between GAPDH and SRR. D-serine 31-39 serine racemase Homo sapiens 111-114 26283510-1 2015 Serine racemase, the enzyme responsible for d-serine synthesis in the central nervous system, has been identified as a potential therapeutic target to treat N-methyl-d-aspartate receptors-related pathologies. D-serine 44-52 serine racemase Homo sapiens 0-15 25493718-8 2015 In addition to a deeper understanding of the racemization mechanism in SerR, based on our simulations we propose specific mutations, which might shift the SerR equilibrium in favor of either l-Ser or d-Ser. D-serine 200-205 serine racemase Homo sapiens 155-159 25462239-2 2015 Production of d-serine, an NMDA receptor co-agonist, from l-serine is catalyzed in vivo by the pyridoxal-5"-phosphate (PLP)-dependent enzyme serine racemase. D-serine 14-22 serine racemase Homo sapiens 141-156 25493718-1 2015 Serine racemase (SerR) is a pyridoxal-5"-phosphate (PLP)-dependent enzyme catalyzing the racemization of l-Ser to d-Ser. D-serine 114-119 serine racemase Homo sapiens 17-21 25493718-2 2015 In mammals, d-Ser is an endogenous coagonist required for the activation of N-methyl-d-aspartate receptors (NMDARs), thus making SerR a promising pharmaceutical target. D-serine 12-17 serine racemase Homo sapiens 129-133 25493718-8 2015 In addition to a deeper understanding of the racemization mechanism in SerR, based on our simulations we propose specific mutations, which might shift the SerR equilibrium in favor of either l-Ser or d-Ser. D-serine 200-205 serine racemase Homo sapiens 71-75 25336657-2 2014 d-Serine is synthesized from l-serine by serine racemase (SR), a brain-enriched enzyme. D-serine 0-8 serine racemase Homo sapiens 41-56 25331425-2 2015 D-Serine is produced by human serine racemase (hSR), a homodimeric pyridoxal 5"-phosphate (PLP)-dependent enzyme that also catalyzes the physiologically relevant beta-elimination of both L- and D-serine to pyruvate and ammonia. D-serine 0-8 serine racemase Homo sapiens 30-45 25336657-2 2014 d-Serine is synthesized from l-serine by serine racemase (SR), a brain-enriched enzyme. D-serine 0-8 serine racemase Homo sapiens 58-60 25336657-4 2014 We now demonstrate that the F-box only protein 22 (FBXO22) interacts with SR and is required for optimal d-serine synthesis in cells. D-serine 105-113 serine racemase Homo sapiens 74-76 25066953-1 2014 D-Serine is a coagonist of the N-methyl-D-aspartate (NMDA)-type glutamate receptor and its biosynthesis is catalyzed by serine racemase (SR). D-serine 0-8 serine racemase Homo sapiens 120-135 25083578-1 2014 D-Serine, an N-methyl D-aspartate receptor coagonist, and its regulatory enzymes, D-amino acid oxidase (DAO; degradation) and serine racemase (SR; synthesis), have been implicated in crucial roles of the developing central nervous system, yet the functional position that they play in regulating the availability of d-serine throughout development of the mammalian retina is not well-known. D-serine 0-8 serine racemase Homo sapiens 126-141 25083578-1 2014 D-Serine, an N-methyl D-aspartate receptor coagonist, and its regulatory enzymes, D-amino acid oxidase (DAO; degradation) and serine racemase (SR; synthesis), have been implicated in crucial roles of the developing central nervous system, yet the functional position that they play in regulating the availability of d-serine throughout development of the mammalian retina is not well-known. D-serine 316-324 serine racemase Homo sapiens 126-141 25164819-2 2014 Serine racemase (SR) is the enzyme that converts L-serine to D-serine. D-serine 61-69 serine racemase Homo sapiens 0-15 25164819-2 2014 Serine racemase (SR) is the enzyme that converts L-serine to D-serine. D-serine 61-69 serine racemase Homo sapiens 17-19 25164819-6 2014 AMPA receptor activation internalizes SR and disrupts its interaction with stargazin, therefore derepressing SR activity, leading to more D-serine production and potentially facilitating NMDA receptor activation. D-serine 138-146 serine racemase Homo sapiens 38-40 25164819-6 2014 AMPA receptor activation internalizes SR and disrupts its interaction with stargazin, therefore derepressing SR activity, leading to more D-serine production and potentially facilitating NMDA receptor activation. D-serine 138-146 serine racemase Homo sapiens 109-111 25066953-1 2014 D-Serine is a coagonist of the N-methyl-D-aspartate (NMDA)-type glutamate receptor and its biosynthesis is catalyzed by serine racemase (SR). D-serine 0-8 serine racemase Homo sapiens 137-139 24795622-5 2014 Among these modulators, a role is emerging for the enzyme serine racemase (SR) that synthesizes D-serine, a key co-agonist with glutamate at NMDAR. D-serine 96-104 serine racemase Homo sapiens 58-73 24795622-5 2014 Among these modulators, a role is emerging for the enzyme serine racemase (SR) that synthesizes D-serine, a key co-agonist with glutamate at NMDAR. D-serine 96-104 serine racemase Homo sapiens 75-77 24795623-3 2014 Moreover, D-serine, its biosynthetic enzyme, serine racemase (SR) and DAO are abundant in human spinal cord and severely depleted in ALS. D-serine 10-18 serine racemase Homo sapiens 45-60 24436034-1 2014 D-Serine, a co-agonist at the NMDA receptor (NMDAR), is synthesized from L-serine by the enzyme serine racemase (SR), which is heavily expressed in the forebrain. D-serine 0-8 serine racemase Homo sapiens 96-111 24436034-1 2014 D-Serine, a co-agonist at the NMDA receptor (NMDAR), is synthesized from L-serine by the enzyme serine racemase (SR), which is heavily expressed in the forebrain. D-serine 0-8 serine racemase Homo sapiens 113-115 24436034-7 2014 Interestingly, only a subset of the D-serine positive neurons contained SR in the neocortex and HP. D-serine 36-44 serine racemase Homo sapiens 72-74 24256252-7 2013 These findings support a model whereby astrocyte-derived L-serine shuttles to neurons to fuel the synthesis of D-serine by serine racemase. D-serine 111-119 serine racemase Homo sapiens 123-138 24237903-2 2014 hDAAO has been proposed to play (with serine racemase; EC 5.1.1.18) an essential role in the catabolism of D-serine, an "atypical" key signalling molecule that acts as allosteric activator of the N-methyl-D-aspartate-type glutamate receptor (NMDAr). D-serine 107-115 serine racemase Homo sapiens 38-53 23992455-3 2013 In the human brain, d-serine is synthesized from l-serine by the dimeric pyridoxal 5"-phosphate-dependent enzyme serine racemase, which also degrades l- and d-serine to pyruvate and ammonia. D-serine 20-28 serine racemase Homo sapiens 113-128 24256253-2 2013 In the brain, the concentration of D-serine stored in cells is defined by the activity of two enzymes: serine racemase (responsible for both the synthesis and degradation) and D-amino acid oxidase (which catalyses D-serine degradation). D-serine 35-43 serine racemase Homo sapiens 103-118 23630460-6 2013 In this review we will examine the data that D-serine and its associated enzyme serine racemase are developmentally regulated. D-serine 45-53 serine racemase Homo sapiens 80-95 23773062-4 2013 This review presents recent evidence that: (i) the amino acid D-serine is an endogenous co-agonist of synaptic NMDA-R and necessary for long-term potentiation expression, (ii) reduced d-serine levels in the hippocampus contribute to synaptic plasticity and memory deficits in normal ageing, and (iii) age-related oxidative stress selectively targets hippocampal serine racemase to impact D-serine availability in neuronal networks. D-serine 62-70 serine racemase Homo sapiens 362-377 23747871-1 2013 Serine racemase is the pyridoxal 5"-phosphate-dependent enzyme that catalyzes L-serine racemisation to D-serine, and L- and D-serine beta-elimination in mammalian brain. D-serine 103-111 serine racemase Homo sapiens 0-15 22311068-1 2012 D-Serine is known to act as an endogenous co-agonist of the N-methyl-D-aspartate receptor in the mammalian brain and is endogenously synthesized from L-serine by a pyridoxal 5"-phosphate-dependent enzyme, serine racemase. D-serine 0-8 serine racemase Homo sapiens 205-220 23116391-2 2013 Cellular concentrations of D-serine are regulated by synthesis due to the enzyme serine racemase (isomerization reaction) and by degradation due to the same enzyme(elimination reaction) as well as by the FAD-containing flavoenzyme D-amino acid oxidase (DAAO, oxidative deamination reaction).Several findings have linked low levels of D-serine to schizophrenia: D-serine concentrations in serum and cerebrospinal fluid have been reported to be decreased in schizophrenia patients while human DAAO activity and expression are increased; oral administration of D-serine improved positive, negative, and cognitive symptoms of schizophrenia as add-on therapy to typical and atypical antipsychotics.This evidence indicates that increasing NMDA receptor function, perhaps by inhibiting DAAO-induced degradation of D-serine may alleviate symptoms in schizophrenic patients. D-serine 27-35 serine racemase Homo sapiens 81-96 23112234-2 2012 Human serine racemase (hSR) and serine dehydratase (hSDH) are two important pyridoxal-5"-phosphate-dependent enzymes that synthesize and degrade D-serine, respectively. D-serine 145-153 serine racemase Homo sapiens 6-21 22311068-2 2012 Though the soil-living mycetozoa Dictyostelium discoideum possesses no genes homologous to that of NMDA receptor, it contains genes encoding putative proteins relating to the D-serine metabolism, such as serine racemase, D-amino acid oxidase, and D-serine dehydratase. D-serine 175-183 serine racemase Homo sapiens 204-219 22311068-4 2012 As part of the elucidation of the role of D-serine in D. discoideum, we cloned, overexpressed, and examined the properties of the putative serine racemase exhibiting 46% amino acid sequence similarity with the human enzyme. D-serine 42-50 serine racemase Homo sapiens 139-154 22354542-1 2012 Serine racemase (SR) is the only identified enzyme in mammals responsible for isomerization of L-serine to D-serine, a coagonist at N-methyl-D-aspartate (NMDA) receptors in the forebrain. D-serine 107-115 serine racemase Homo sapiens 0-15 22507034-5 2012 Forced expression of SR, together with treatment with NMDA and d-serine, blocks neuronal death, whereas pharmacological inhibition and Sh-RNA-mediated suppression of endogenous SR exacerbate neuronal death. D-serine 63-71 serine racemase Homo sapiens 21-23 22354542-1 2012 Serine racemase (SR) is the only identified enzyme in mammals responsible for isomerization of L-serine to D-serine, a coagonist at N-methyl-D-aspartate (NMDA) receptors in the forebrain. D-serine 107-115 serine racemase Homo sapiens 17-19 22037294-7 2012 This method was used to determine the concentration-dependent increases in D-Ser and associated EC50 values produced by L-Ser and the concentration-dependent decreases in d-Ser and associated IC50 values produced by glycine, a competitive inhibitor of serine racemase (SR). D-serine 171-176 serine racemase Homo sapiens 252-267 21655447-4 2011 Eph receptors regulate this response by inducing the dephosphorylation of PKCalpha and activation of serine racemase to convert L-serine to D-serine. D-serine 140-148 serine racemase Homo sapiens 101-116 27466949-1 2011 Serine racemase (SR) is a PLP-dependent enzyme catalyzing the racemization of L-Ser into D-Ser, which is now recognized as an endogenous co-agonist at the NMDA receptor complex. D-serine 89-94 serine racemase Homo sapiens 0-15 27466949-1 2011 Serine racemase (SR) is a PLP-dependent enzyme catalyzing the racemization of L-Ser into D-Ser, which is now recognized as an endogenous co-agonist at the NMDA receptor complex. D-serine 89-94 serine racemase Homo sapiens 17-19 21956576-1 2012 Serine racemase is a glial and neuronal enzyme that reversibly converts L-serine to D-serine, an endogenous co-agonist of N-methyl-D-aspartate receptor type glutamate receptors (NMDARs). D-serine 84-92 serine racemase Homo sapiens 0-15 21224019-2 2011 Synthesis of d-serine is carried out by serine racemase (SR), a pyridoxal 5"-phosphate-dependent enzyme. D-serine 13-21 serine racemase Homo sapiens 40-55 21224019-2 2011 Synthesis of d-serine is carried out by serine racemase (SR), a pyridoxal 5"-phosphate-dependent enzyme. D-serine 13-21 serine racemase Homo sapiens 57-59 21224019-5 2011 I propose a role for SR in a novel form of astrocyte-neuron communication-the "serine shuttle", whereby astrocytes synthesize and export l-serine required for the synthesis of d-serine by the predominantly neuronal SR. D-serine 176-184 serine racemase Homo sapiens 21-23 21224019-8 2011 The higher content of d-serine in astrocytes appears to be related to increased d-serine stability, for their low SR expression will prevent substantial d-serine metabolism via alpha,beta-elimination. D-serine 22-30 serine racemase Homo sapiens 114-116 21291385-6 2011 D-serine is a product of the activity of a specific enzyme, serine racemase (SR), which was identified a decade ago. D-serine 0-8 serine racemase Homo sapiens 60-75 21291385-6 2011 D-serine is a product of the activity of a specific enzyme, serine racemase (SR), which was identified a decade ago. D-serine 0-8 serine racemase Homo sapiens 77-79 21392888-9 2011 They may also produce d-serine because astrocytic processes were selectively immunolabeled for serine racemase, the d-serine synthesizing enzyme. D-serine 22-30 serine racemase Homo sapiens 95-110 21886585-3 2011 Serine racemase converts l-serine to d-serine, which is an endogenous co-agonist for NMDA receptors. D-serine 37-45 serine racemase Homo sapiens 0-15 21886585-9 2011 Because the C allele of rs408067 reduces the expression of SRR, a lower d-serine level or reduced NMDA receptor activation may affect the prognosis of methamphetamine psychosis and multiple substance abuse. D-serine 72-80 serine racemase Homo sapiens 59-62 20091774-0 2010 D-Serine metabolism in C6 glioma cells: Involvement of alanine-serine-cysteine transporter (ASCT2) and serine racemase (SRR) but not D-amino acid oxidase (DAO). D-serine 0-8 serine racemase Homo sapiens 103-118 20966073-1 2010 In mammalian brain, D-serine is synthesized from L-serine by serine racemase, and it functions as an obligatory co-agonist at the glycine modulatory site of N-methyl-D-aspartate (NMDA)-selective glutamate receptors. D-serine 20-28 serine racemase Homo sapiens 61-76 20417696-6 2010 In addition, polymorphisms have been described in modulatory systems involving the NMDAR, including the enzymes serine racemase and d-amino acid oxidase/G72 that regulate brain d-serine synthesis. D-serine 177-185 serine racemase Homo sapiens 112-127 21106840-7 2010 Eph receptors mediate this response through interactions with PICK1 (protein interacting with C-kinase) and by dephosphorylating protein kinase C alpha to activate the conversion of l-serine to d-serine by serine racemase. D-serine 194-202 serine racemase Homo sapiens 206-221 20623543-4 2010 Double-immunofluorescence study revealed that up-regulation of serine racemase immunoreactivity was relevant not to D-serine immunoreactivity but to nestin or vimentin immunoreactivity. D-serine 116-124 serine racemase Homo sapiens 63-78 20091774-7 2010 SRR overexpression increased D-serine and pyruvate and decreased [(3)H]D-serine uptake and ASCT2 mRNA but did not affect DAO. D-serine 29-37 serine racemase Homo sapiens 0-3 20091774-10 2010 The factors regulating D-serine are important for understanding normal NMDA receptor function and because D-serine, along with DAO and SRR, is implicated in the pathogenesis and treatment of schizophrenia. D-serine 23-31 serine racemase Homo sapiens 135-138 20106978-1 2010 Serine racemase is responsible for the synthesis of D-serine, an endogenous co-agonist for N-methyl-D-aspartate receptor-type glutamate receptors (NMDARs). D-serine 52-60 serine racemase Homo sapiens 0-15 20106978-3 2010 Because D-serine affects NMDAR signaling throughout the brain, serine racemase is a promising target for the treatment of disorders related to NMDAR dysfunction. D-serine 8-16 serine racemase Homo sapiens 63-78 20091774-0 2010 D-Serine metabolism in C6 glioma cells: Involvement of alanine-serine-cysteine transporter (ASCT2) and serine racemase (SRR) but not D-amino acid oxidase (DAO). D-serine 0-8 serine racemase Homo sapiens 120-123 20091774-2 2010 It is synthesized from L-serine by serine racemase (SRR), but many aspects of its metabolism remain unclear, especially in the forebrain, which lacks active D-amino acid oxidase (DAO), the major D-serine degradative enzyme. D-serine 195-203 serine racemase Homo sapiens 52-55 20091774-3 2010 Candidate mechanisms include SRR operating in alpha,beta-eliminase mode (converting D-serine to pyruvate) and regulation by serine transport, in which the alanine-serine-cysteine transporter ASCT2 is implicated. D-serine 84-92 serine racemase Homo sapiens 29-32 20021361-4 2009 Neuronal and endothelial NO synthase (nNOS and eNOS) in astrocytes cross-talk with serine racemase (SR) and D-amino acid oxydase (DAAO), catalyzing the synthesis and degradation of D-serine, respectively. D-serine 181-189 serine racemase Homo sapiens 83-98 17663143-5 2007 D-Serine is synthesized by serine racemase (SR) from L-serine. D-serine 0-8 serine racemase Homo sapiens 27-42 19791805-1 2009 Mammalian serine racemase (SR) is a pyridoxal-5"-phosphate (PLP) dependent enzyme responsible for the biosynthesis of the neurotransmitter D-serine, which activates N-methyl-D-aspartate (NMDA) receptors in the CNS. D-serine 139-147 serine racemase Homo sapiens 10-25 19193859-3 2009 We show that serine racemase (SR), which generates D-serine from L-serine, is physiologically inhibited by phosphatidylinositol (4,5)-bisphosphate (PIP2) presence in membranes where SR is localized. D-serine 51-59 serine racemase Homo sapiens 13-28 19193859-3 2009 We show that serine racemase (SR), which generates D-serine from L-serine, is physiologically inhibited by phosphatidylinositol (4,5)-bisphosphate (PIP2) presence in membranes where SR is localized. D-serine 51-59 serine racemase Homo sapiens 30-32 19193859-3 2009 We show that serine racemase (SR), which generates D-serine from L-serine, is physiologically inhibited by phosphatidylinositol (4,5)-bisphosphate (PIP2) presence in membranes where SR is localized. D-serine 51-59 serine racemase Homo sapiens 182-184 17880399-1 2007 The N-methyl-D-aspartate receptor co-agonist d-serine is synthesized by serine racemase and degraded by D-amino acid oxidase. D-serine 45-53 serine racemase Homo sapiens 72-87 17880399-9 2007 These findings establish the major cell types wherein serine racemase and D-amino acid oxidase are expressed in human brain and provide some support for aberrant D-serine metabolism in schizophrenia. D-serine 162-170 serine racemase Homo sapiens 54-69 19640845-2 2009 Mammalian pyridoxal 5"-phosphate-dependent serine racemase, which is localized in the mammalian brain, catalyzes the racemization of L-serine to yield D-serine and vice versa. D-serine 151-159 serine racemase Homo sapiens 43-58 19155267-1 2009 Serine racemase synthesizes d-serine, a physiological agonist of the NMDA receptor in mammalian brains. D-serine 28-36 serine racemase Homo sapiens 0-15 18812225-2 2009 The enzyme responsible for D-serine biosynthesis, serine racemase (SR), is therefore a promising target for treatment of neuropathologies related to glutamate receptor excitotoxicity, such as stroke or Alzheimer"s disease. D-serine 27-35 serine racemase Homo sapiens 50-65 18812225-2 2009 The enzyme responsible for D-serine biosynthesis, serine racemase (SR), is therefore a promising target for treatment of neuropathologies related to glutamate receptor excitotoxicity, such as stroke or Alzheimer"s disease. D-serine 27-35 serine racemase Homo sapiens 67-69 18564178-1 2008 It has been recently established that in various brain regions D-serine, the product of serine racemase, occupies the so-called "glycine site" within N-methyl D-aspartate receptors. D-serine 63-71 serine racemase Homo sapiens 88-103 17663143-5 2007 D-Serine is synthesized by serine racemase (SR) from L-serine. D-serine 0-8 serine racemase Homo sapiens 44-46 17627481-4 2007 The induction of D-serine production by Abeta involves transcriptional and/or translational regulation of serine racemase gene. D-serine 17-25 serine racemase Homo sapiens 106-121 16721908-0 2006 Capillary electrophoresis method for determination of D-serine and its application for monitoring of serine racemase activity. D-serine 54-62 serine racemase Homo sapiens 101-116 17254537-4 2007 In avian organs, such as the kidney, in addition to DAO, D-serine is also degraded to pyruvate by D-serine dehydratase (DSD). D-serine 57-65 serine racemase Homo sapiens 98-118 17293453-0 2007 Nitric oxide S-nitrosylates serine racemase, mediating feedback inhibition of D-serine formation. D-serine 78-86 serine racemase Homo sapiens 28-43 17293453-1 2007 Serine racemase (SR) generates D-serine, a coagonist with glutamate at NMDA receptors. D-serine 31-39 serine racemase Homo sapiens 0-15 17293453-1 2007 Serine racemase (SR) generates D-serine, a coagonist with glutamate at NMDA receptors. D-serine 31-39 serine racemase Homo sapiens 17-19 17156977-10 2007 Our results suggest that reduced brain serine racemase and elevated D-amino acid oxidase protein levels may contribute to the lower CSF D-serine levels in schizophrenia. D-serine 136-144 serine racemase Homo sapiens 39-54 17006901-4 2006 D-Serine is synthesized in glial cells by serine racemase (SR) and released upon activation of glutamate receptors. D-serine 0-8 serine racemase Homo sapiens 42-57 17006901-4 2006 D-Serine is synthesized in glial cells by serine racemase (SR) and released upon activation of glutamate receptors. D-serine 0-8 serine racemase Homo sapiens 59-61 16837850-3 2006 We studied the expression of serine racemase, an astrocytic enzyme which synthesizes the N-methyl-D-aspartate receptor coagonist D-serine, using Western blot analysis in postmortem hippocampus and cortex in schizophrenia and a comparison group. D-serine 129-137 serine racemase Homo sapiens 29-44 16714286-0 2006 Modulation of D-serine levels via ubiquitin-dependent proteasomal degradation of serine racemase. D-serine 14-22 serine racemase Homo sapiens 81-96 16714286-1 2006 Mammalian serine racemase is a brain-enriched enzyme that converts L- into D-serine in the nervous system. D-serine 75-83 serine racemase Homo sapiens 10-25 16714286-12 2006 Modulation of serine racemase degradation, such as that promoted by Golga3, provides a new mechanism for regulating brain d-serine levels and NMDA receptor activity. D-serine 122-130 serine racemase Homo sapiens 14-29 16551623-2 2006 Biosynthesis of D-serine is carried out by serine racemase, which converts L- to D-serine. D-serine 16-24 serine racemase Homo sapiens 43-58 16721908-1 2006 Serine racemase (SR) is an enzyme responsible for the biosynthesis of D-serine, the coagonist of the N-methyl-D-aspartate receptor, in the brain. D-serine 70-78 serine racemase Homo sapiens 0-15 16721908-1 2006 Serine racemase (SR) is an enzyme responsible for the biosynthesis of D-serine, the coagonist of the N-methyl-D-aspartate receptor, in the brain. D-serine 70-78 serine racemase Homo sapiens 17-19 15953485-2 2005 In this study, we examined the genetic roles of serine racemase (SRR), an enzyme catalyzing the formation of D-serine from L-serine, and D-amino-acid oxidase (DAO) in the susceptibility to schizophrenia and the regulation of serum D-serine levels. D-serine 231-239 serine racemase Homo sapiens 48-63 16298487-3 2006 Recently, we have reported that serine racemase (SR) is inhibited by NO and activated by D-serine through nitrosylation and denitrosylation, respectively [K. Shoji, S. Mariotto, A.R. D-serine 89-97 serine racemase Homo sapiens 32-47 16298487-3 2006 Recently, we have reported that serine racemase (SR) is inhibited by NO and activated by D-serine through nitrosylation and denitrosylation, respectively [K. Shoji, S. Mariotto, A.R. D-serine 89-97 serine racemase Homo sapiens 49-51 16298487-4 2006 Ciampa, H. Suzuki, Regulation of serine racemase activity by D-serine and nitric oxide in human glioblastoma cells, Neurosci. D-serine 61-69 serine racemase Homo sapiens 33-48 15953485-2 2005 In this study, we examined the genetic roles of serine racemase (SRR), an enzyme catalyzing the formation of D-serine from L-serine, and D-amino-acid oxidase (DAO) in the susceptibility to schizophrenia and the regulation of serum D-serine levels. D-serine 109-117 serine racemase Homo sapiens 48-63 15953485-2 2005 In this study, we examined the genetic roles of serine racemase (SRR), an enzyme catalyzing the formation of D-serine from L-serine, and D-amino-acid oxidase (DAO) in the susceptibility to schizophrenia and the regulation of serum D-serine levels. D-serine 109-117 serine racemase Homo sapiens 65-68 16314870-3 2006 In this study, we identify and characterize protein interacting with C-kinase (PICK1) as a protein interactor of the D-serine synthesizing enzyme, serine racemase (SR). D-serine 117-125 serine racemase Homo sapiens 147-162 16314870-3 2006 In this study, we identify and characterize protein interacting with C-kinase (PICK1) as a protein interactor of the D-serine synthesizing enzyme, serine racemase (SR). D-serine 117-125 serine racemase Homo sapiens 164-166 16182447-0 2006 Regulation of serine racemase activity by D-serine and nitric oxide in human glioblastoma cells. D-serine 42-50 serine racemase Homo sapiens 14-29 16182447-1 2006 In the human glioblastoma cell line U87, the activity of serine racemase (SR), catalyzing the isomerisation of serine, was inversely regulated by D-serine and nitric oxide (NO), a neuromodulator and a neurotransmitter, respectively. D-serine 146-154 serine racemase Homo sapiens 57-72 16182447-1 2006 In the human glioblastoma cell line U87, the activity of serine racemase (SR), catalyzing the isomerisation of serine, was inversely regulated by D-serine and nitric oxide (NO), a neuromodulator and a neurotransmitter, respectively. D-serine 146-154 serine racemase Homo sapiens 74-76 16182447-2 2006 SR activity was dose-dependently enhanced up to five times in cells treated with 10 mM D-serine, whereas it was inhibited by NO. D-serine 87-95 serine racemase Homo sapiens 0-2 16182447-4 2006 These results suggest that serine racemase activity in astrocyte is regulated inversely by d-serine and NO. D-serine 91-99 serine racemase Homo sapiens 27-42 16182447-5 2006 SR should be inhibited through nitrosylation by NO and activated through denitrosylation elicited by D-serine. D-serine 101-109 serine racemase Homo sapiens 0-2 15953485-2 2005 In this study, we examined the genetic roles of serine racemase (SRR), an enzyme catalyzing the formation of D-serine from L-serine, and D-amino-acid oxidase (DAO) in the susceptibility to schizophrenia and the regulation of serum D-serine levels. D-serine 231-239 serine racemase Homo sapiens 65-68 15953485-4 2005 Single nucleotide polymorphisms (SNPs) in SRR and DAO were tested for their association with schizophrenia in both case-control and family-based designs and for correlation with serum levels of D-serine. D-serine 194-202 serine racemase Homo sapiens 42-45 15536068-0 2005 Serine racemase modulates intracellular D-serine levels through an alpha,beta-elimination activity. D-serine 40-48 serine racemase Homo sapiens 0-15 15536068-2 2005 D-Serine is synthesized by serine racemase, a brain enriched enzyme converting L- to D-serine. D-serine 0-8 serine racemase Homo sapiens 27-42 15536068-4 2005 We now report that serine racemase catalyzes the degradation of cellular D-serine itself, through the alpha,beta-elimination of water. D-serine 73-81 serine racemase Homo sapiens 19-34 15536068-14 2005 Extracellular D-serine is more stable toward alpha,beta-elimination, likely due to physical separation from serine racemase and its elimination activity. D-serine 14-22 serine racemase Homo sapiens 108-123 16543946-2 2004 D-serine is synthesized from L-serine by serine racemase in astrocytic glia that ensheath synapses, especially in regions of the brain that are enriched in NMDA-glutamate receptors. D-serine 0-8 serine racemase Homo sapiens 41-56 15193426-2 2004 Synthesis of D-serine is catalyzed by the serine racemase enzyme. D-serine 13-21 serine racemase Homo sapiens 42-57 15193426-7 2004 Human embryonic kidney 293 cells transiently transfected with this SRR gene were able to produce d-serine, indicating that the sequence encodes for an active enzyme. D-serine 97-105 serine racemase Homo sapiens 67-70 15193426-14 2004 The cloning of a functional human serine racemase and its expression in central nervous system of primates support a role for D-serine in neuronal activity. D-serine 126-134 serine racemase Homo sapiens 34-49 15681805-1 2004 Serine racemase (SRace) is an enzyme that catalyzes the conversion of L-serine to pyruvate or D-serine, an endogenous agonist for NMDA receptors. D-serine 94-102 serine racemase Homo sapiens 0-15 15681805-1 2004 Serine racemase (SRace) is an enzyme that catalyzes the conversion of L-serine to pyruvate or D-serine, an endogenous agonist for NMDA receptors. D-serine 94-102 serine racemase Homo sapiens 17-22 15252817-4 2004 A new enzyme, serine racemase has been localized to glial cells and converts L-serine to D-serine. D-serine 89-97 serine racemase Homo sapiens 14-29 15306409-5 2004 The synthesis of D-serine in brain is due to a pyridoxal-5"-phosphate (B(6))-requiring serine racemase in glia. D-serine 17-25 serine racemase Homo sapiens 87-102 15306409-6 2004 Although it remains unknown when serine racemase first evolved, data concerning the evolution of B(6) enzymes, along with the known occurrences of serine racemases in animals, point to D-serine synthesis arising around the divergence time of arthropods. D-serine 185-193 serine racemase Homo sapiens 33-48 16543946-6 2004 This causes glutamate-receptor-interacting protein, which binds serine racemase, to stimulate enzyme activity and D-serine release. D-serine 114-122 serine racemase Homo sapiens 64-79 11309496-0 2001 A new strategy to decrease N-methyl-D-aspartate (NMDA) receptor coactivation: inhibition of D-serine synthesis by converting serine racemase into an eliminase. D-serine 92-100 serine racemase Homo sapiens 125-140 12176074-7 2002 We previously showed that D-serine is synthesized by a glial serine racemase, a novel enzyme converting L- to D-serine in mammalian brain. D-serine 26-34 serine racemase Homo sapiens 61-76 12393813-0 2002 Cofactors of serine racemase that physiologically stimulate the synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine. D-serine 128-136 serine racemase Homo sapiens 13-28 12393813-3 2002 d-serine is synthesized by a serine racemase (SR) enzyme, which directly converts l- to d-serine. D-serine 0-8 serine racemase Homo sapiens 29-44 12393813-4 2002 We now report that SR is a bifunctional enzyme, producing both d-serine and pyruvate in cultured cells and in vitro. D-serine 63-71 serine racemase Homo sapiens 19-21 12393813-5 2002 Transfection of SR into HEK 293 cells elicits synthesis of d-serine and augmented release of pyruvate to culture media. D-serine 59-67 serine racemase Homo sapiens 16-18 12393813-6 2002 We identified substances present in HEK 293 and astrocyte cell extracts that strongly stimulate d-serine production by SR and elicit production of pyruvate. D-serine 96-104 serine racemase Homo sapiens 119-121 12393813-8 2002 As much as three molecules of pyruvate are synthesized for each molecule of d-serine produced by SR. D-serine 76-84 serine racemase Homo sapiens 97-99 11864625-2 2002 D-Serine is synthesized from L-serine by the activity of a glial enriched serine racemase, but little is known on the properties of D-serine transport and factors regulating its synaptic concentration. D-serine 0-8 serine racemase Homo sapiens 74-89 15285800-6 2004 Microglial cell lysates were examined for the levels of mRNA and protein for serine racemase, the enzyme that forms D-serine from L-serine. D-serine 116-124 serine racemase Homo sapiens 77-92 12796220-9 2003 In addition, the percentage of D-serine in the total serine in the schizophrenic patients was significantly (z = -4.78, P<.001) lower than that of controls, suggesting that the activity of serine racemase, an enzyme catalyzing the formation of D-serine from L-serine, may have been reduced in the schizophrenic patients. D-serine 31-39 serine racemase Homo sapiens 192-207 12796220-9 2003 In addition, the percentage of D-serine in the total serine in the schizophrenic patients was significantly (z = -4.78, P<.001) lower than that of controls, suggesting that the activity of serine racemase, an enzyme catalyzing the formation of D-serine from L-serine, may have been reduced in the schizophrenic patients. D-serine 247-255 serine racemase Homo sapiens 192-207 12021263-1 2002 Serine racemase (SR) is a brain enzyme present in glial cells, where it isomerizes L-serine into D-serine that, in turn, diffuses and coactivates the N-methyl-D-aspartate receptor through the binding to the so-called "glycine site." D-serine 97-105 serine racemase Homo sapiens 0-15 12021263-1 2002 Serine racemase (SR) is a brain enzyme present in glial cells, where it isomerizes L-serine into D-serine that, in turn, diffuses and coactivates the N-methyl-D-aspartate receptor through the binding to the so-called "glycine site." D-serine 97-105 serine racemase Homo sapiens 17-19 11309496-1 2001 Serine racemase is a brain-enriched enzyme that synthesizes d-serine, an endogenous modulator of the glycine site of N-methyl-d-aspartate (NMDA) receptors. D-serine 60-68 serine racemase Homo sapiens 0-15 11058466-8 2000 D-Serine is formed by serine racemase, which directly converts L-serine to D-serine. D-serine 0-8 serine racemase Homo sapiens 22-37 11058466-8 2000 D-Serine is formed by serine racemase, which directly converts L-serine to D-serine. D-serine 75-83 serine racemase Homo sapiens 22-37 10781100-2 2000 Localizations of D-serine and it biosynthetic enzyme serine racemase approximate the distribution of NMDA receptors more closely than glycine. D-serine 17-25 serine racemase Homo sapiens 53-68 10905615-5 2000 D-serine is also formed by serine racemase, a recently cloned enzyme that converts L-serine to D-serine. D-serine 0-8 serine racemase Homo sapiens 27-42 10905615-5 2000 D-serine is also formed by serine racemase, a recently cloned enzyme that converts L-serine to D-serine. D-serine 95-103 serine racemase Homo sapiens 27-42 11054547-3 2000 We now report cloning and expression of human serine racemase, an enzyme that catalyses the synthesis of D-serine from L-serine. D-serine 105-113 serine racemase Homo sapiens 46-61 11054547-6 2000 Northern-blot analysis show high levels of human serine racemase in areas known to contain large amounts of endogenous D-serine, such as hippocampus and corpus callosum. D-serine 119-127 serine racemase Homo sapiens 49-64 11054547-7 2000 Robust synthesis of D-serine was detected in cells transfected with human serine racemase, demonstrating the conservation of D-amino acid metabolism in humans. D-serine 20-28 serine racemase Homo sapiens 74-89 11054547-8 2000 Serine racemase may be a therapeutic target in psychiatric diseases as supplementation of D-serine greatly improves schizophrenia symptoms. D-serine 90-98 serine racemase Homo sapiens 0-15 10557334-0 1999 Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission. D-serine 45-53 serine racemase Homo sapiens 0-15 10557334-4 1999 We now report cloning and expression of serine racemase, an enzyme catalyzing the formation of D-serine from L-serine. D-serine 95-103 serine racemase Homo sapiens 40-55 29410194-1 2018 Serine racemase is a pyridoxal 5"-phosphate dependent enzyme responsible for the synthesis of d-serine, a neuromodulator of the NMDA receptors. D-serine 94-102 serine racemase Homo sapiens 0-15 34874398-8 2021 Given that serine racemase is the enzyme involved in the synthesis of d-ser, and l-beta-EHAsn is also a substrate for DSD, further investigations could verify if this amino acid would be involved in the metabolic regulation of pathways involving d-ser. D-serine 70-75 serine racemase Homo sapiens 11-26 30687716-1 2018 Human serine racemase is a pyridoxal 5"-phosphate (PLP)-dependent dimeric enzyme that catalyzes the reversible racemization of L-serine and D-serine and their dehydration to pyruvate and ammonia. D-serine 140-148 serine racemase Homo sapiens 6-21 30687716-2 2018 As D-serine is the co-agonist of the N-methyl-D-aspartate receptors for glutamate, the most abundant excitatory neurotransmitter in the brain, the structure, dynamics, function, regulation and cellular localization of serine racemase have been investigated in detail. D-serine 3-11 serine racemase Homo sapiens 218-233 34806751-7 2021 Given that serine racemase is the enzyme involved in the synthesis of D-ser, and L-beta-EHAsn is also a substrate for DSD, further investigations could verify if this amino acid would be involved in the metabolic regulation of pathways involving D-ser. D-serine 70-75 serine racemase Homo sapiens 11-26 30918891-1 2019 Serine racemase (SR) is the first racemase enzyme to be identified in human biology and converts L-serine to D-serine, an important neuronal signaling molecule that serves as a co-agonist of the NMDA (N-methyl-D-aspartate) receptor. D-serine 109-117 serine racemase Homo sapiens 0-15 30918891-1 2019 Serine racemase (SR) is the first racemase enzyme to be identified in human biology and converts L-serine to D-serine, an important neuronal signaling molecule that serves as a co-agonist of the NMDA (N-methyl-D-aspartate) receptor. D-serine 109-117 serine racemase Homo sapiens 17-19 30546256-6 2018 A special enzyme, serine racemase (SR), is required for the conversion of L-serine into D-serine, and alterations in SR activities lead to a variety of physiological and pathological conditions ranging from synaptic plasticity to ischemia, MI, and stroke. D-serine 88-96 serine racemase Homo sapiens 18-33 30546256-6 2018 A special enzyme, serine racemase (SR), is required for the conversion of L-serine into D-serine, and alterations in SR activities lead to a variety of physiological and pathological conditions ranging from synaptic plasticity to ischemia, MI, and stroke. D-serine 88-96 serine racemase Homo sapiens 35-37 30546256-6 2018 A special enzyme, serine racemase (SR), is required for the conversion of L-serine into D-serine, and alterations in SR activities lead to a variety of physiological and pathological conditions ranging from synaptic plasticity to ischemia, MI, and stroke. D-serine 88-96 serine racemase Homo sapiens 117-119 30546256-7 2018 The amount of D-serine available for the activation of glutamatergic signalling is largely determined by SR and we have developed ways to estimate its levels in human blood samples and correlate it with the IMT. D-serine 14-22 serine racemase Homo sapiens 105-107 30546256-8 2018 This research based short communication describes our pilot study, which clearly suggests that there is a direct relationship between the SR, D-serine, and IMT. D-serine 142-150 serine racemase Homo sapiens 138-140 30555832-3 2018 Among the enzymatic candidates, serine racemase (SR) has recently gathered an increasing interest considering that it tightly regulates the production of d-serine, an amino acid now viewed as the main endogenous co-agonist necessary for NMDAR activation. D-serine 154-162 serine racemase Homo sapiens 32-47 30555832-3 2018 Among the enzymatic candidates, serine racemase (SR) has recently gathered an increasing interest considering that it tightly regulates the production of d-serine, an amino acid now viewed as the main endogenous co-agonist necessary for NMDAR activation. D-serine 154-162 serine racemase Homo sapiens 49-51 30093356-2 2018 Conversely, inhibition of pancreatic NMDA receptors as well as loss of the d-serine producing enzyme serine racemase have been shown to modulate insulin secretion. D-serine 75-83 serine racemase Homo sapiens 101-116 29025687-3 2018 N-methyl-D-aspartate receptor activation requires the binding of a coagonist, D-serine, which is synthesized from L-serine by the neuronal enzyme serine racemase (SR). D-serine 78-86 serine racemase Homo sapiens 146-161 29363864-2 2018 Serine racemase (SRR) is responsible for transforming L-serine to D-serine. D-serine 66-74 serine racemase Homo sapiens 0-15 29363864-2 2018 Serine racemase (SRR) is responsible for transforming L-serine to D-serine. D-serine 66-74 serine racemase Homo sapiens 17-20 29566294-1 2018 Serine racemase (SR) is an enzyme that catalyses the synthesis of d-serine, an endogenous coagonist for N-methyl-D-aspartate (NMDA)-type glutamate receptor in the central nervous system. D-serine 66-74 serine racemase Homo sapiens 0-15 29566294-1 2018 Serine racemase (SR) is an enzyme that catalyses the synthesis of d-serine, an endogenous coagonist for N-methyl-D-aspartate (NMDA)-type glutamate receptor in the central nervous system. D-serine 66-74 serine racemase Homo sapiens 17-19 29025687-11 2018 We also demonstrate that the SRR single nucleotide polymorphism, rs4523957, is associated with posttraumatic stress disorder in humans, consistent with the facilitatory effect of D-serine on fear extinction. D-serine 179-187 serine racemase Homo sapiens 29-32 29277459-1 2018 Most of the endogenous free d-serine (about 90%) in the brain is produced by serine racemase (SR). D-serine 28-36 serine racemase Homo sapiens 77-92 29277459-1 2018 Most of the endogenous free d-serine (about 90%) in the brain is produced by serine racemase (SR). D-serine 28-36 serine racemase Homo sapiens 94-96 28696262-1 2017 There is currently great interest in human serine racemase, the enzyme responsible for producing the NMDA co-agonist d-serine. D-serine 117-125 serine racemase Homo sapiens 43-58 29413526-2 2018 d-Serine is synthesized by the enzyme serine racemase, which converts l- to d-serine. D-serine 0-8 serine racemase Homo sapiens 38-53 28560262-7 2017 Conversely, no significant changes were found in the methylation state and transcription of DDO gene in patients with schizophrenia, compared to control individuals, as well as in the expression levels of serine racemase, the major enzyme responsible for d-serine biosynthesis, which also catalyzes aspartate racemization. D-serine 255-263 serine racemase Homo sapiens 205-220